Diagnostic Evaluation of<sup>67</sup>Ga Scanning of Lung Cancer and Other Diseases

Ito, Yasuhiko; Okuyama, Shuhei; Awano, Takayuki; Takahashi, Kunibumi; Sato, Tachio; Kanno, Iwao

doi:10.1148/101.2.355

Cited by 69 publications

(19 citation statements)

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“…Gallium-67-citrate 67 Gallium-citrate has been used for infection and inflammation imaging ever since its discovery in 1971 [1,2]. Upon intravenous injection 67 Ga binds to transferrin.…”

Section: Radiopharmaceuticals Currently Usedmentioning

confidence: 99%

“…The ideal radiopharmaceutical for infection/inflammation imaging should meet the following criteria: [1] efficient accumulation and good retention in inflammatory foci; [2] rapid clearance from background; [3] no accumulation in noninflamed tissues; [4] no side-effects; [5] low cost ( 99m Tc) and easy preparation (kit formulation); [6] discrimination between infection and non-microbial inflammation.…”

Section: Introductionmentioning

confidence: 99%

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Radiopharmaceuticals for scintigraphic imaging of infection and inflammation

Boerman¹,

Dams²,

Oyen³

et al. 2001

Inflammation Research

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Scintigraphic imaging of infection and inflammation is a powerful diagnostic tool in the management of patients with infectious or inflammatory diseases. Most infectious and inflammatory foci can be visualized accurately with radiolabeled autologous leukocytes. However, preparation of this radiopharmaceutical is laborious and requires the handling of potentially contaminated blood. Nowadays, a few radiopharmaceuticals are available that could replace radiolabeled leukocytes, such as: 67Ga-citrate, 99mTc-IgG and 99mTc-labeled antigranulocyte antibody preparations. Furthermore, various agents labeled with 99mTc are currently developed for this application: chemotactic peptides, cytokines and liposomes. Here, the characteristics and the diagnostic potential of established and experimental radiopharmaceuticals for infection and inflammation imaging are reviewed.

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“…Gallium-67-citrate 67 Gallium-citrate has been used for infection and inflammation imaging ever since its discovery in 1971 [1,2]. Upon intravenous injection 67 Ga binds to transferrin.…”

Section: Radiopharmaceuticals Currently Usedmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Radiopharmaceuticals for scintigraphic imaging of infection and inflammation

Boerman¹,

Dams²,

Oyen³

et al. 2001

Inflammation Research

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“…Imaging of infectious and inflammatory sites using cyclotron-produced gallium-67 ( 67 Ga) citrate has been carried out since 1971 [1][2][3][4][5][6]. Several factors in the complex cellular uptake mechanism of 67 Ga citrate, including the transchelation of 67 Ga 3 + as an Fe 3 + analogue to transferrin, lactoferrin and bacterial siderophores, contribute to the accumulation and retention of gallium radioactivity in both acute and chronic inflammatory lesions of bacterial and nonbacterial origin [7][8][9], making 67 Ga citrate a useful tool in the management of patients with these infectious and inflammatory diseases.…”

Section: Introductionmentioning

confidence: 99%

Fast and simple one-step preparation of 68Ga citrate for routine clinical PET

Jensen

Nielsen²,

Mewis³

et al. 2013

Nuclear Medicine Communications

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The imaging of infectious and inflammatory diseases using gallium-67 (⁶⁷Ga) citrate scintigraphy has been a well-established diagnostic tool for decades. In recent times, interest has focused on PET using the short-lived positron emitting radioisotope ⁶⁸Ga. ⁶⁸Ga is not only more readily available, it also provides better quality images whose high resolution permits quantitative analyses, thus improving the management of patients suffering from infections or inflammation. The purpose of our study was to develop a fast and reliable synthesis protocol for the preparation of ⁶⁸Ga citrate under good manufacturing practice aspects without the use of organic solvents. A commercially available synthesis module was used to perform 10 syntheses with an average yield of 768 ± 31 MBq (mean ± SD) within 10 min; 92.04 ± 1.23% of the radioactivity was located in the product vial, and the rest on the cation exchange cartridge (7.48 ± 1.23%) and in the waste vial (0.47 ± 0.28%). The radiochemical purity of the product determined by instant thin-layer chromatography was greater than 99%. The products have been proven to be sterile and pyrogen-free. Variations were made in several critical synthesis parameters, and the results are presented herein. By eliminating the use of organic solvents, the previously required quality control testing of the final product by gas chromatography can be abandoned. This novel, high-yielding method allows for a more efficient synthesis of ⁶⁸Ga citrate with both shorter production time and high radiochemical purity.

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“…False-positive sign was noted in the right hilum. 2°1T1 Accumulation was also observed in these regions, but the primary lesion was superimposed on myocardial accumulation of 2OLT1 and the false-negative rate was 0% 22% (Ito et al 1971 ;Hjelms and Dyrbe 1975). With a thallium-201 planar image sensitivity has been reported as being 70%-90% lower than with 67Ga (Salvatore etal.…”

Section: Discussionmentioning

confidence: 92%

Effectiveness of planar image and single photon emission tomography of thallium-201 compared with gallium-67 in patients with primary lung cancer

et al. 1992

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A comparative study of planar images and single photon emission tomography (SPET) of thallium-201 chloride and gallium-67 citrate was performed in 38 patients with proven primary lung cancer to detect the primary lung tumour and to establish the presence of metastasis in the lung hilum and mediastinum. The findings of planar images and SPET were compared with the pathological findings after thoracotomy. It was shown that 201Tl studies were superior to 67Ga studies for evaluation of the primary lesion and lymph node metastases.

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Diagnostic Evaluation of⁶⁷Ga Scanning of Lung Cancer and Other Diseases

Cited by 69 publications

References 1 publication

Radiopharmaceuticals for scintigraphic imaging of infection and inflammation

Radiopharmaceuticals for scintigraphic imaging of infection and inflammation

Fast and simple one-step preparation of 68Ga citrate for routine clinical PET

Effectiveness of planar image and single photon emission tomography of thallium-201 compared with gallium-67 in patients with primary lung cancer

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Diagnostic Evaluation of67Ga Scanning of Lung Cancer and Other Diseases

Cited by 69 publications

References 1 publication

Radiopharmaceuticals for scintigraphic imaging of infection and inflammation

Radiopharmaceuticals for scintigraphic imaging of infection and inflammation

Fast and simple one-step preparation of 68Ga citrate for routine clinical PET

Effectiveness of planar image and single photon emission tomography of thallium-201 compared with gallium-67 in patients with primary lung cancer

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Diagnostic Evaluation of⁶⁷Ga Scanning of Lung Cancer and Other Diseases