Diagnostic evaluation and treatment of osteoarticular lesions in patients having sickle cell anemia: Literature review
Nathalie de Sena Pereira,
Luiz da Costa Nepomuceno Filho,
Rômulo dos Santos Cavalcante
et al.
Abstract:Sickle cell anemia is a genetic disorder in which the structure of hemoglobin undergoes a significant alteration through a point mutation in the β-globin gene. When the gene is altered in sickle cell disease, hemoglobin S is expressed, causing the red blood cell to acquire the characteristic sickle shape. Thus, in the presence of this mutation, especially with changes in oxygen concentration and pH, hemoglobin S tends to polymerize, resulting in sickling of the red blood cells, leading to a shortened lifespan … Show more
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