Diagnostic et traitements actuels du saturnisme

Klein, Marc; Kaminsky, P.; Duc, M.

doi:10.1016/s0248-8663(05)81182-8

Cited by 4 publications

(1 citation statement)

References 33 publications

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“…High alkaline phosphatase concentrations reflect the increase in bone turnover. Several conditions known to increase bone turnover, such as pregnancy (12)(13)(14), chemotherapy (15)(16)(17), tumorous infiltration of bone (18), or postmenopausal osteoporosis (19), may be associated with the mobilisation of lead in bone stores, leading to chronic lead poisoning. Hyperthyroidism is known to increase bone remodelling (20)(21)(22).…”

Section: Discussionmentioning

confidence: 99%

Lead poisoning secondary to hyperthyroidism: report of two cases

Klein

Barbé²,

Pascal³

et al. 1998

European Journal of Endocrinology

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With long-term exposure to lead, lead accumulates in bone, where it is stored for years. These quiescent lead stores are mobilised when increased bone turnover occurs, and latent lead toxicity may then become symptomatic. Although Graves' disease is a common cause of increased bone turnover, to date hyperthyroidism has been implicated in lead poisoning only twice. We describe herein two cases of hyperthyroidism, one caused by toxic multinodular thyroid enlargement, the second by Graves' disease, leading to lead poisoning. Treatment of hyperthyroidism with radioactive iodine cured both hyperthyroidism and lead poisoning and no chelating agent therapy was necessary. Lead poisoning is an important environmental health problem, and physicians must be aware of the endocrine disorders such as hyperthyroidism and hyperparathyroidism that increase bone turnover, favouring lead mobilisation. Atypical symptoms should draw the physician's attention to the possibility of lead poisoning, particularly in workers with occupational exposure to lead and in areas where lead poisoning is endemic.

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Section: Discussionmentioning

confidence: 99%

Lead poisoning secondary to hyperthyroidism: report of two cases

Klein

Barbé²,

Pascal³

et al. 1998

European Journal of Endocrinology

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Un cas « historique » de saturnisme hydrique : difficultés diagnostiques et thérapeutiques

Testud

Girtanner-Brunel

Peaud

et al. 2001

La Revue de Médecine Interne

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Effects of direct exposure to lead on some haematological parameters among battery repair workers in Mosul

Al-Ameen¹,

Bashir²

2008

Ann Coll Med Mosul

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Objectives:Determination of the degree of lead exposure and to study the possible effects of lead on different haematological parameters. Methods:A haematological study of thirty battery repair workers and thirty-four blood donors (as a control) in the period of 2 months (January -February 1998). All the workers and the donors were subjected to a clinical and laboratory evaluation. The laboratory tests included complete blood picture, blood lead level determination and iron status study.Results: Analysis of lead in the blood showed that the mean blood lead level (BLL) of these workers was significantly higher than that of the control (P< 0.001). 20% of the battery repairers had symptoms, while 16.7% of them had normochromic normocytic anaemia and 23.3% had reticulocytosis. Iron status was normal in all of the repairers but it was found that transferrin saturation of the repairers with BLL of more than 70 µg/dl RBC was significantly higher (P< 0.05) than those repairers with BLL of or less than 70 µg/dl RBC. Conclusion:Battery repairing is an important new source of lead exposure in our community and periodic medical supervision is required as well as improvement of their working conditions.

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Diagnostic et traitements actuels du saturnisme

Cited by 4 publications

References 33 publications

Lead poisoning secondary to hyperthyroidism: report of two cases

Lead poisoning secondary to hyperthyroidism: report of two cases

Un cas « historique » de saturnisme hydrique : difficultés diagnostiques et thérapeutiques

Effects of direct exposure to lead on some haematological parameters among battery repair workers in Mosul

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