Diagnostic efficiency of toluidine blue with Lugol′s iodine in oral premalignant and malignant lesions

Kamarthi, Nagaraju; Prasad, Shiva; Ashok, L

doi:10.4103/0970-9290.66633

Cited by 44 publications

(37 citation statements)

References 15 publications

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“…Considering the inherent limitations of toluidine blue as a diagnostic test our results are in accordance with other studies (Epstein et al, 1997;Nagaraju et al, 2010;Chaudhari et al, 2013). However, results were different from other studies (Myers, 1970;Mashberg and Feldman, 1988) who observed specificity to be much higher 100% and 95% respectively.…”

Section: Discussionsupporting

confidence: 62%

Effectiveness of the Microlux/DLTM Chemiluminescence Device in Screening of Potentially Malignant and Malignant Oral Lesions

Ibrahim

Al-Attas²,

Darwish³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: To evaluate the effectiveness of Microlux/DL with and without toluidine blue in screening of potentially malignant and malignant oral lesions. Materials and Methods: In this diagnostic clinical trial clinical examination was carried out by two teams: 1) two oral medicine consultants, and 2) two general dentists. Participants were randomly and blindly allocated for each examining team. A total of 599 tobacco users were assessed through conventional oral examination (COE); the examination was then repeated using Microlux/DL device and toluidine blue. Biopsy of suspicious lesions was performed. Also clinicians opinions regarding the two tools were obtained. Results: The sensitivity and, specificity and positive predictive value (PVP) of Microlux/DL for visualization of suspicious premalignant lesions considering COE as a gold standard (i.e screening device) were 94.3%, 99.6% and 96.2% respectively, while they were 100%, 32.4% and 17.9% when considering biopsy as a gold standard. Moreover, Microlux/DL enhanced detection of the lesion and uncovered new lesions compared to COE, whereas it did not alter the provisional clinical diagnosis, or alter the biopsy site. On the other hand, adding toluidine blue dye did not improve the effectiveness of the Microlux/DL system. Conclusions: The Microlux/DL seems to be a promising adjunctive screening device.

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Section: Discussionsupporting

confidence: 62%

Effectiveness of the Microlux/DLTM Chemiluminescence Device in Screening of Potentially Malignant and Malignant Oral Lesions

Ibrahim

Al-Attas²,

Darwish³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…The authors concluded that Lugol's iodine had less sensitivity in identifying oral malignant and dysplastic lesions but it had greater specificity. Moreover, in another study, 30 subjects with clinically suspicious oral PMDs and 30 subjects with clinically suspicious malignant lesions were stained consecutively with TB and Lugol's iodine, the overall sensitivity in detecting dysplasia or malignant lesions was 92.7% while the specificity was 60% (Nagaraju et al 2010). Most of the studies consulted found the Lugol's iodine might have great potential for oral PMDs and oral cancer screening.…”

Section: Lugol's Iodine Stainingmentioning

confidence: 99%

Non-Invasive Techniques for Detection and Diagnosis of Oral Potentially Malignant Disorders

Liu

Zhao

Zeng

et al. 2016

Tohoku J. Exp. Med.

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Oral squamous cell carcinoma (OSCC) is the most common oral and maxillofacial malignancy, and its morbidity and mortality rates are still high in most countries. Oral potentially malignant disorders (PMDs) are used to refer to a heterogeneous group of conditions that are characterized by increased risk for malignant transformation to OSCC. Currently identified oral PMDs include leukoplakia, erythroplakia, palatal lesions associated with reverse smoking, oral lichen planus, oral submucous fibrosis, actinic keratosis, and discoid lupus erythematosus. The early detection and diagnosis of these lesions are important for cancer prevention and disease management. In recent years, there has been a growing and persistent demand for new non-invasive, practical diagnostic techniques that might facilitate the early detection of oral PMDs. The non-invasive detection techniques evaluated in this review are divided into four categories: vital staining with a solution that can be used as a mouth rinse or applied onto a suspected area of the mouth, light-based detection systems, optical diagnostic technologies that employ returned optical signals to reflect structural and morphological changes within tissues, and salivary biomarkers. Most of these techniques have shown great potential for screening and monitoring oral PMDs. In this review article, the authors critically assess these non-invasive detection techniques for oral PMDs. We also provide a summary of the sensitivity and specificity of each technique in detecting oral PMDs and oral cancer, as well as their advantages, disadvantages, clinical applications, and indications.

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“…The acetic acid does not affect the mature, glycogen-producing epithelium because the acid does not penetrate below the outer one-third of the epithelium [12]. The cells in this region have very small nuclei and a very large amount of glycogen [12].…”

Section: Staining Procedures Acetic Acid Washmentioning

confidence: 99%

“…The cells in this region have very small nuclei and a very large amount of glycogen [12]. Dysplastic cells are the ones which are most affected.…”

Section: Staining Procedures Acetic Acid Washmentioning

confidence: 99%

“…Staining of the Lugol's iodine depends on the glycogen content present in the normal epithelium and this selective character of staining helps in delineating the inflammatory or carcinomatous epithelium from the normal epithelium where the glycogen content is low. Brown stain was considered as positive for lesions while lesions without any retention of stain were considered as negative [12].…”

Section: Lugol Solutionmentioning

confidence: 99%

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Colposcopy - A Novel Diagnostic Technique for Oral Mucosal Lesions

Kumar

Prakash

et al. 2014

JCDR

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Diagnostic efficiency of toluidine blue with Lugol′s iodine in oral premalignant and malignant lesions

Cited by 44 publications

References 15 publications

Effectiveness of the Microlux/DLTM Chemiluminescence Device in Screening of Potentially Malignant and Malignant Oral Lesions

Effectiveness of the Microlux/DLTM Chemiluminescence Device in Screening of Potentially Malignant and Malignant Oral Lesions

Non-Invasive Techniques for Detection and Diagnosis of Oral Potentially Malignant Disorders

Colposcopy - A Novel Diagnostic Technique for Oral Mucosal Lesions

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