Diagnostic efficiency of 68Ga-DOTANOC PET/CT in patients with suspected tumour-induced osteomalacia

He, Qiao; Zhang, Bing; Zhang, Linqi; Chen, Zhifeng; Shi, Xiulin; Chen, Yi; Wang, Xiaoyan; Zhang, Xiangsong

doi:10.1007/s00330-020-07342-2

Cited by 9 publications

(6 citation statements)

References 33 publications

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“…The same patient may have several tumors; therefore, clinicians should be alert as to whether a patient with TIO has several tumors. Locating all tumors by CT or MRI is not easy, but PET/CT is able to identify all potential tumors, and 68 Ga-DOTATATE PET/CT is a powerful diagnostic tool for locating the true culprit of TIO (19,20). In summary, few reports have focused on patients with TIO whose diagnosis is impaired by the presence of multiple tumors.…”

Section: Discussionmentioning

confidence: 99%

A diagnostic challenge of mysterious bone pain caused by tumor-induced osteomalacia with multiple tumors: a case report

Liu¹,

Wang²,

Huang³

et al. 2023

Transl Cancer Res

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Tumor-induced osteomalacia (TIO) is a rare, paraneoplastic syndrome in which the patient presents with acquired hypophosphatemic osteomalacia. The clinical characteristics of TIO are very similar to those of genetic hypophosphatemic rickets (1-3). Previous research has indicated that tumor-induced humoral factors play a crucial role in the pathogenesis of TIO (4). For patients who are eligible for surgery, TIO can be completely cured by resecting the tumor (2), while pharmacological interventions are useful for patients for whom surgery is not possible (5).However, despite the treatability of TIO, its diagnosis and differential diagnosis remain a clinical challenge, in

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Section: Discussionmentioning

confidence: 99%

A diagnostic challenge of mysterious bone pain caused by tumor-induced osteomalacia with multiple tumors: a case report

Liu¹,

Wang²,

Huang³

et al. 2023

Transl Cancer Res

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“…Venous blood sampling for FGF-23 is a helpful tool to show the existence of the tumor rather than localizing it [35] , [36] . The rather new modality of 68 Ga-DOTA-TOC-PET/CT-scan (using ocreotide as mentioned above) is most sensitive in finding the underlying tumors [14] , [37] , [38] but fails to identify the mass in up to 30–40% [4] . As demonstrated in our case, a stepwise diagnostic approach can be effective, including 68 Ga-DOTA-TOC-PET/CT-scan, venous sampling for FGF-23 levels and localized MRI of the suspected region [39] .…”

Section: Discussion and Review Of The Literaturementioning

confidence: 99%

“…Imaging modalities for tumor detection include MRI and FDG-PET. In case of detection failure, 68 Ga-DOTA-TOC-PET/CT-scan is a more sensitive tool to find the tumor [14] , [15] , [16] . A genetic etiology must be excluded once TIO is suspected as X-linked hypophosphatemia, autosomal dominant hypophosphatemic rickets and autosomal recessive hypophosphatemic rickets may mimic the disease [17] , [18] , [19] , [20] .…”

Section: Introductionmentioning

confidence: 99%

FGF-23 transmitted tumor – induced hypophosphatemic osteomalacia: A rare case of a young woman with recurrent fractures and review of the literature

Frank

Gerber

Cornelius

et al. 2022

Journal of Bone Oncology

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Highlights Tumor-transmitted osteomalacia is a rare FGF 23 transmitted phosphaturic disease. Delay of diagnosis is common due to small and clinically silent underlying tumors. The most sensitive imaging modality is 68 Ga-DOTA-TOC-PET/CT-scan. Complete resection of the tumor mass cures this paraneoplastic disease.

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“…As Qiao He reported ( 29 ), no specific preparation of the patients was required before 68Ga-DOTANOC PET-CT and 18F-FDG examination. PET-CT imaging was performed with a Gemini GXL 16 PET scanner (Philips Healthcare).…”

Section: Methodsmentioning

confidence: 99%

Comparison of 68Ga-DOTANOC and 18F-FDG PET-CT Scans in the Evaluation of Primary Tumors and Lymph Node Metastasis in Patients With Rectal Neuroendocrine Tumors

et al. 2021

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BackgroundLymph node metastasis of rectal neuroendocrine tumors (RNETs) predicts poor prognosis. However, the assessment of lymph node metastasis remains a challenge. It has been reported that 68Ga-DOTANOC and 18F-FDG PET-CT scans could be employed in the work-up of rectal neuroendocrine tumors (RNETs). This study aimed to assess both tracers’ ability to identify primary tumors and lymph node (LN) metastasis in RNETs.MethodsA total of 537 patients with RNETs were enrolled from January 2014 to January 2021. Both 68Ga-DOTANOC and 18F-FDG PET-CT scans were used to evaluate primary tumors and LN group metastasis. PET images were evaluated through visual and semiquantitative assessment. Receiver Operating Characteristics (ROC) curve analysis was used to investigate the performance of SUVmax of 68Ga-DOTANOC and 18F-FDG PET in predicting LN group metastasis.ResultsFifty-two patients with preoperative 68Ga-DOTANOC with 18F-FDG PET-CT scans underwent endoscopic biopsy or dissection of the primary tumor, while 11 patients underwent rectal surgery together with regional LN dissection. For primary tumors, 68Ga-DOTANOC had a sensitivity of 89.58% and a positive predictive value (PPV) of 95.56% through visual assessment, while 18F-FDG PET-CT showed 77.08% sensitivity and 97.37% PPV. For the prediction of LN group metastasis, 68Ga-DOTANOC PET-CT had 77.78% sensitivity and 91.67% specificity, while 18F-FDG PET-CT had 38.89% sensitivity and 100% specificity according to visual assessment. The area under the ROC curves (AUC) for 68Ga-DOTANOC PET/CT was 0.852 (95%CI:0.723-0.981) with an optimal SUVmax cut-off value of 2.25, while the AUC for 18F-FDG PET were 0.664 (95%CI:0.415-0.799) with an optimal SUVmax cut-off value of 1.05.ConclusionsThis study showed that 68Ga-DOTANOC PET-CT was a promising tool for detecting LN metastasis in RNETs with high sensitivity and specificity in visual assessment and semiquantitative assessment, which was better than 18F-FDG PET-CT.

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Diagnostic efficiency of 68Ga-DOTANOC PET/CT in patients with suspected tumour-induced osteomalacia

Cited by 9 publications

References 33 publications

A diagnostic challenge of mysterious bone pain caused by tumor-induced osteomalacia with multiple tumors: a case report

A diagnostic challenge of mysterious bone pain caused by tumor-induced osteomalacia with multiple tumors: a case report

FGF-23 transmitted tumor – induced hypophosphatemic osteomalacia: A rare case of a young woman with recurrent fractures and review of the literature

Comparison of 68Ga-DOTANOC and 18F-FDG PET-CT Scans in the Evaluation of Primary Tumors and Lymph Node Metastasis in Patients With Rectal Neuroendocrine Tumors

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