Diagnostic Efficacy of Serum Amyloid A Protein and Soluble Intercellular Adhesion Molecule 1 in Pediatric Ventilator-Associated Pneumonia

Abo-Hagar, Hamdy; Abo-Elezz, Ahmed Abd ElBasset; Mehrez, Mostafa; Mabrouk, Maaly M.; Elshora, Ola A

doi:10.1177/0885066617702598

Cited by 7 publications

(8 citation statements)

References 29 publications

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“…The expression level of ICAM-1 of patients in NAFLD group almost had no change. This is inconsistent with literature reports where it was found that the ICAM-1 levels were increased when using a coronary artery injury model after CABG (may be due to the vascular damage response), or that the levels were low in other conditions (may be because of a negative feedback regulation mechanisms) ( 18 , 19 ). Then again, it was found in this study that the expression levels of MMP-9 in peripheral blood of patients in the two groups were highest one day after the CABG procedure, and that the levels in the NAFLD group were significantly higher than those in the non-NAFLD group (p<0.01).…”

Section: Discussioncontrasting

confidence: 99%

Changes in inflammatory factors and prognosis of patients complicated with non-alcoholic fatty liver disease undergoing coronary artery bypass grafting

Wang

Gong

2017

Exp Ther Med

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Abstract. This study was designed to assess the relationship between changes in peripheral inflammatory factors of patients complicated with non-alcoholic fatty liver disease (NAFLD) undergoing coronary artery bypass grafting (CABG) before and after operation, and their prognosis. A total of 68 patients with stable angina pectoris treated in Xinjiang Hospital who underwent CABG at some point between August of 2013 and August of 2015 were enrolled in the study, and divided into the NAFLD group (n=31) and the non-NAFLD group (n=37) according to the presence of the condition or its absence. Peripheral blood was drawn from the patients before and at 24 h and 1 month after the operation, and the expression levels of high-sensitivity C-reactive protein (hsCRP), soluble CD40 ligand (sCD40L), intercellular adhesion molecule-1 (ICAM-1) and matrix metalloproteinase-9 (MMP-9) were measured via standard enzyme-linked immunosorbent assay. Our results showed the expression levels of hsCRP and sCD40L of patients in both groups reached a peak 24 h after operation; and there were statistically significant changes compared with the levels before the operation and at 1 month after operation (p<0.01). However, there were no statistically significant differences in the expression levels between the two groups (p>0.05). The expression levels of ICAM-1 at each time-point in both groups were increased after the operation, but the changes were not statistically significant (p>0.05). The expression levels of MMP-9 increased after the operation, and the levels at 1 month after operation were significantly higher than those before operation and at 24 h after the operation (p<0.01). Importantly, the expression levels of MMP-9 of patients in the NAFLD group at 1 month after operation were significantly higher than those of patients in the non-NAFLD group at the same time, and the differences were statistically significant (p<0.01). Finally, logistic regression analysis showed that the expression level of MMP-9 was an important influencing factor for cardiovascular events after CABG (OR=1.182, p<0.05). Based on our findings, the expression levels of inflammatory factors in peripheral blood in patients complicated with NAFLD undergoing CABG differ from those who are not complicated, and the MMP-9 levels may be closely related to the prognosis of patients complicated with NAFLD. IntroductionWith the continuous improvement of living standards in China, the incidence of non-alcoholic fatty liver disease (NAFLD), a disease previously almost exclusive of Western countries, has been increasing year by year, and it has become one of the most common liver diseases affecting human health (1,2). Studies have shown that NAFLD can lead to metabolic disorders and diseases, which are closely related to hypertension and coronary heart disease (3). Cardiac bypass surgery and coronary stent implantation are common effective surgical treatments for coronary heart disease. But a series of adverse cardiovascular events after surgery still seriously threaten the l...

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Section: Discussioncontrasting

confidence: 99%

Changes in inflammatory factors and prognosis of patients complicated with non-alcoholic fatty liver disease undergoing coronary artery bypass grafting

Wang

Gong

2017

Exp Ther Med

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“…Lymphocyte count and NLR are convenient and quick indexes of inflammation detection in laboratory examination; they are used in the diagnosis, treatment, and prognosis evaluation of many diseases (Reddy and Lsymj, 2020;Ljungström et al, 2017). SAA, as a newer biomarker, has been reported to increase the accuracy of diagnosing pneumonia and other infections (Abo-Hagar et al, 2019;Azurmendi et al, 2017;Prendki et al, 2020). Through the combined detection of SAA and other indicators in patients, this study found that the joint detection of indicators displayed better performance than detection of a single indicator.…”

Section: Discussionmentioning

confidence: 70%

SAA and CRP are potential indicators in distinction and severity assessment for children with influenza

Zou

Liu

Yang

et al. 2021

International Journal of Infectious Diseases

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The clinical values of C-reactive protein (CRP) and serum amyloid A (SAA) to distinguish nonsevere from severe influenza in children are rarely reported. Methods: Baseline characteristics and laboratory results were collected and analyzed. Receiver operating characteristic (ROC) curve analysis was used for combined detection of indicators for children with influenza, and scatter-dot plots were used to compare the differences between non-severe and severe influenza. Results: Children with influenza B had more bronchitis and pneumonia (P < 0.05) and children with influenza A had more other serious symptoms (P = 0.015). Lymphocyte count, neutrophil count, neutrophil-to-lymphocyte ratio (NLR), CRP, and SAA performed differently among children with influenza A and B. Joint detection of SAA and other indicators could better separate healthy children from children with influenza than single indicator detection. The CRP and SAA levels of children with severe influenza B infection and SAA levels of children with severe influenza A infection were significantly elevated compared with children with non-severe influenza (P < 0.05). Conclusions: SAA and CRP could be potential indicators in distinction and severity assessment for children with influenza; however, age should be taken into account when using them in children with influenza B.

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“…SAA is an acute-phase protein mostly synthesized by the liver, with a significantly shorter half-life than CRP [ 24 ]. In the pediatric setting, SAA predicted the presence of ventilator-acquired pneumonia with a sensitivity of 100% and a specificity of 93% [ 25 ]. Azurmendi et al showed that SAA was elevated in patients at risk to develop post-stroke infections [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Accuracy of C-reactive protein, procalcitonin, serum amyloid A and neopterin for low-dose CT-scan confirmed pneumonia in elderly patients: A prospective cohort study

Prendki¹,

Malézieux-Picard²,

Azurmendi

et al. 2020

PLoS ONE

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The diagnosis of pneumonia based on semiology and chest X-rays is frequently inaccurate, particularly in elderly patients. Older (C-reactive protein (CRP); procalcitonin (PCT)) or newer (Serum amyloid A (SAA); neopterin (NP)) biomarkers may increase the accuracy of pneumonia diagnosis, but data are scarce and conflicting. We assessed the accuracy of CRP, PCT, SAA, NP and the ratios CRP/NP and SAA/NP in a prospective observational cohort of elderly patients with suspected pneumonia. Methods We included consecutive patients more than 65 years old, with at least one respiratory symptom and one symptom or laboratory finding suggestive of infection, and a working diagnosis of pneumonia. Low-dose CT scan and comprehensive microbiological testing were done in all patients. The index tests, CRP, PCT, SAA and NP, were obtained within 24 hours. The reference diagnosis was assessed a posteriori by a panel of experts considering all available data, including patients' outcome. We used area under the curve (AUROC) and Youden index to assess the accuracy and obtain optimal cutoff of the index tests.

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Diagnostic Efficacy of Serum Amyloid A Protein and Soluble Intercellular Adhesion Molecule 1 in Pediatric Ventilator-Associated Pneumonia

Abstract: Serum amyloid A and sICAM-1 may be considered as reliable markers for detection of VAP. Combination of serum SAA with CPIS increased the specificity to 100%. Measurement of SAA in patients with VAP also had a good predictive value for nonsurvival in such patients.

Cited by 7 publications

References 29 publications

Changes in inflammatory factors and prognosis of patients complicated with non-alcoholic fatty liver disease undergoing coronary artery bypass grafting

Changes in inflammatory factors and prognosis of patients complicated with non-alcoholic fatty liver disease undergoing coronary artery bypass grafting

SAA and CRP are potential indicators in distinction and severity assessment for children with influenza

Accuracy of C-reactive protein, procalcitonin, serum amyloid A and neopterin for low-dose CT-scan confirmed pneumonia in elderly patients: A prospective cohort study

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