Diagnostic efficacy of erythrocyte sedimentation rate in horses: an integrative systematic review

Benvenutti, Márcio Eduardo de Melo; Miranda, João Antônio Leal de; Costa, Áthila Henrique Cipriano da; Jorge, Samuel Monteiro; Vaz, Antônio Fernando de Melo

doi:10.33448/rsd-v11i3.26416

Cited by 2 publications

(2 citation statements)

References 11 publications

(15 reference statements)

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“…Te erythrocyte sedimentation rate is a commonly used laboratory test in humans to assess the presence of many pathological conditions such as infammation [1,25] though it is afected by various factors [7,[12][13][14][15]. In horses, ESR was widely engaged to evaluate the presence of infections or infammatory disorders [26] and to monitor the physiological status before and after a race or a training as well as the time used to return to normal ESR values. Tese fuctuations have been explained by some investigations showing how the exercise in horse can induce changes in both hematocrit and ESR levels, specifcally an increase during physical activity and a decrease during rest [12,14].…”

Section: Discussionmentioning

confidence: 99%

Analytical Validation of MINI‐PET as Point‐of‐Care for Erythrocyte Sedimentation Rate Measure in Horses

Pieroni,

Grassi,

Pantoli

et al. 2023

Veterinary Medicine International

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The erythrocyte sedimentation rate (ESR) is a widely used diagnostic assay in human medicine but nowadays poorly applied in veterinary medicine. This test measures the speed (millimeters per hour) at which red blood cells settle in a whole anticoagulated blood tube. In human medicine, high ESR values are associated with various disorders, including infections, rheumatoid arthritis, oncologic diseases, and other inflammatory conditions. The ESR can also be influenced by some factors such as age and gender. In veterinary medicine, the ESR with the Westergren manual method was almost forgotten over the years due to blood consumption and long turn-around time. The instrument MINI-PET, using a modified Westergren method, does not require blood consumption or release waste product and recently has been applied in canine medicine. The aims of the study in the horse were as follows: to establish the appropriate time to read the ESR with the Westergren reference method; to compare the MINI-PET ESR results with the reference technique; to assess the ESR reference intervals with MINI-PET; and to establish the ESR stability from collection at different time points by MINI-PET. Using 150 horses, we established 60 minutes as the appropriate time for ESR reading with the Westergren method. Moreover, ESR results obtained in 8 minutes with MINI-PET showed a good correlation with the Westergren ESR. Reference intervals (RIs) with MINI-PET were established in mm/h for the healthy horses (geldings 18.6–100.1; stallions, 13.8–55.7; and mares 1–73.7) according to the American Society of Veterinary Clinical Pathology guidelines. In addition, the ESR stability from the blood collection time was evaluated in the MINI-PET on 15 horses: at room temperature, ESR is stable up to 8 hours and at 4°C up to 24 hours. In conclusion, MINI-PET represents a rapid and reliable tool for measuring ESR in horses, offering a valid option to replace the traditional manual technique.

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Section: Discussionmentioning

confidence: 99%

Analytical Validation of MINI‐PET as Point‐of‐Care for Erythrocyte Sedimentation Rate Measure in Horses

Pieroni,

Grassi,

Pantoli

et al. 2023

Veterinary Medicine International

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“…In the last few years, additional studies have been carried out on the ESR application as an important marker in animals' inflammatory diseases [18,19], as well as in canine osteoarthritis [20] and in chronic kidney disease (CKD) [21]. However, in veterinary medicine, the ESR has been used in the past, but acute phase proteins are nowadays recommended when investigating inflammation [22][23][24][25] because conventional methods to measure ESR are time-consuming.…”

Section: Introductionmentioning

confidence: 99%

Increased Erythrocyte Sedimentation Rate in Dogs: Frequency in Routine Clinical Practice and Association with Hematological Changes

Paltrinieri,

Ferrari,

Scavone

et al. 2024

Animals

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(1) Background: the erythrocyte sedimentation rate (ESR) has been reported to increase in some infectious or inflammatory diseases in dogs, but no information on the frequency of increases in a routine clinical setting exists. The aim of this study was to assess the frequency of an increased ESR in dogs and to investigate its possible association with hematologic changes; (2) Methods: A total of 295 EDTA blood samples were randomly selected from the routine caseload of the Veterinary Teaching Hospital. Samples were grouped in controls and in pathologic groups based on the clinical presentation. A routine hemogram was performed, then the ESR was measured using the instrument MINI-PET; (3) Results: compared with controls, the ESR was significantly higher in all the pathologic groups, except for the hematological disorders group. The highest ESR was found in samples from dogs with chronic kidney disease or inflammation, followed by those from dogs with mild chronic disorders, severe/acute diseases, tumors and urinary disorders. The ESR negatively correlated with hematocrit and positively with neutrophil counts. (4) Conclusions: The ESR increases more frequently in dogs with clinically evident inflammation or CKD, but also in several other conditions, likely as a consequence of anemia and acute phase response.

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Diagnostic efficacy of erythrocyte sedimentation rate in horses: an integrative systematic review

Cited by 2 publications

References 11 publications

Analytical Validation of MINI‐PET as Point‐of‐Care for Erythrocyte Sedimentation Rate Measure in Horses

Analytical Validation of MINI‐PET as Point‐of‐Care for Erythrocyte Sedimentation Rate Measure in Horses

Increased Erythrocyte Sedimentation Rate in Dogs: Frequency in Routine Clinical Practice and Association with Hematological Changes

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