Diagnostic Distortions: A Case Report of Progressive Apraxia of Speech

Brodtmann, Amy; Pemberton, Hugh; Darby, David; Vogel, Adam P.

doi:10.3233/jad-160069

Cited by 5 publications

(1 citation statement)

References 17 publications

(27 reference statements)

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“…Acoustic measures can quantify diagnostically relevant features of stroke-induced AOS (Duffy, 2020;McNeil et al, 2017) and there is now converging evidence that they can also aid the description and differential diagnosis of PAOS (Ballard et al, 2014;Brodtmann et al, 2016;Cordella et al, 2019;Duffy et al, 2017Duffy et al, , 2015Laganaro et al, 2012;R. Utianski et al, Under Review;Wilson et al, 2010).…”

Section: Acoustic Correlatesmentioning

confidence: 99%

Primary progressive apraxia of speech: from recognition to diagnosis and care

2020

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Background: Apraxia of speech (AOS) can be caused by neurodegenerative disease and sometimes is its presenting sign (i.e., primary progressive apraxia of speech, PPAOS). During the last several decades, our understanding of PPAOS has evolved from clinical recognition to a fuller understanding of its core and associated clinical features, its distinction from but relationship with primary progressive aphasia, its temporal course and eventual progression to include other neurological deficits, and its neuroimaging correlates and underlying pathology. Aims: This paper provides a comprehensive summary of the literature that has built the current knowledge base about PPAOS and progressive AOS as it co-occurs with progressive aphasia. It reviews the history of its emergence as a recognized syndrome; its relationship with the agrammatic/nonfluent variant of primary progressive aphasia; its salient perceptual features and subtypes; the acoustic and structural/physiological imaging measures that index its presence, severity, and distinction from aphasia; and principles and available data regarding its management and care. Main Contribution: A broad summary of what is known about AOS as a manifestation of neurodegenerative disease. Conclusions: Primary progressive apraxia of speech is a recognizable syndrome that can be distinguished from other neurodegenerative conditions that affect speech and language.

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Section: Acoustic Correlatesmentioning

confidence: 99%

Primary progressive apraxia of speech: from recognition to diagnosis and care

2020

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Linking motor speech function and dementia

Poole

Vogel

2020

Genetics, Neurology, Behavior, and Diet in Dementia

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L’apport critique de l’évaluation de la communication dans le diagnostic précoce de l’apraxie primaire progressive de la parole

Bouvier

Monetta

Laforce³

et al. 2017

Can. J. Aging

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Primary progressive apraxia of speech (PPAoS) is a neurodegenerative syndrome characterized by speech apraxia at its onset; as it progresses, it often evolves into total mutism. Even though this syndrome is increasingly recognized, its early differential diagnostic is still complex. The objective of this study was to illustrate why a fine evaluation of speech and language is essential for the differential diagnosis of PPAoS. This longitudinal case study presents the progression of a PPAoS patient over a period of 5 years. Periodic neurological and speech-language assessments were carried out to follow the progression of neurological, memory, language and speech symptoms. The different diagnostic labels established over time were also reported. The evolution of the patient's communication profile was characterized by a preservation of language components and episodic memory, in parallel with a progressive deterioration of speech which gradually reduced intelligibility, and was associated with signs of spasticity, resulting in a complete anarthria. This case study sheds light upon the evolution of a patient with PPAoS. A better understanding of the clinical profile and progression of PPAoS is necessary in order to improve early diagnosis and adequate care for these patients.

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Diagnostic Distortions: A Case Report of Progressive Apraxia of Speech

Cited by 5 publications

References 17 publications

Primary progressive apraxia of speech: from recognition to diagnosis and care

Primary progressive apraxia of speech: from recognition to diagnosis and care

Linking motor speech function and dementia

L’apport critique de l’évaluation de la communication dans le diagnostic précoce de l’apraxie primaire progressive de la parole

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