Diagnostic difficulty arising from displaced epithelium after core biopsy in intracystic papillary lesions of the breast

Douglas-Jones, Anthony; Verghese, A

doi:10.1136/jcp.55.10.780

Cited by 45 publications

(27 citation statements)

References 6 publications

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“…In breast lesions, indication for surgery is usually determined by pathological diagnosis together with radiological findings but differential, preoperative diagnosis of papillary carcinoma from papilloma is very difficult, even following needle biopsy (26) because of their non-specific radiological characteristics and their modest cytological and histological appearance (6). Hence, in the clinical management of these lesions, surgical excision is recommended, especially when associated to identified risk factors of malignancy, such as high age (≥ 50 years) and the presence of microcalcifications (27,28).…”

Section: Discussionmentioning

confidence: 99%

Intracystic Papillary Carcinoma of Breast Harbors Significant Genomic Alteration Compared with Intracystic Papilloma: Genome-wide Copy Number and LOH Analysis Using High-Density Single-Nucleotide Polymorphism Microarrays

et al. 2011

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Running title Molecular-cytogenetic Profile of ICPTs KEY WORDS Intracystic papillary tumor, breast cancer, array CGH, GeneChip®, FFPE 2 ABSTRACTPurpose: Intracystic papillary breast tumors consist of benign papilloma, carcinoma in situ and carcinoma with invasion. Using high-density single-nucleotide polymorphism arrays, this study aimed to determine the profile of genomic alterations in these lesions and to identify novel diagnostic criteria. Methods: Ten samples of intracystic papillary tumor, which included five papillomas (Pap), three papillary carcinomas in situ (PurePC) and two papillary carcinomas with invasion (PCinv), were studied. DNA was extracted from tumor and normal tissues that were microdissected from the same formalin-fixed paraffin embedded blocks. Using probe intensity and genotype data from high-density oligonucleotide SNP microarrays (Affymetrix® GeneChip Genome-wide Human 5.0), paired copy number and LOH analysis was performed using Partek Genomic Suite Software. Results: Quality control (QC) call rate, which is an index measuring the quality of a SNP microarray experiment, ranged from 70.75% to 91.93%, mean 80.72%. The mean total genomic alteration rate (sum of amplifications, deletions and copy-neutral loss of heterogeneity) with respect to the whole genome was 2.87%,

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Section: Discussionmentioning

confidence: 99%

Intracystic Papillary Carcinoma of Breast Harbors Significant Genomic Alteration Compared with Intracystic Papilloma: Genome-wide Copy Number and LOH Analysis Using High-Density Single-Nucleotide Polymorphism Microarrays

et al. 2011

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“…Additionally, epithelial displacement is a well-documented phenomenon that can be seen after a needle core biopsy or even fine-needle aspiration of papillary lesions. 24,25 This is due to the escape of friable tumor clusters from the affected duct spaces as the needle punctures the lesion. This results in detection of tumor cells outside the lesion and pseudoinvasion, which can be further complicating.…”

Section: Myoepithelial Cell Markers In the Evaluationmentioning

confidence: 99%

Diagnostic Role of Immunohistochemistry in the Evaluation of Breast Pathology Specimens

Zhao

Yang

Khan

et al. 2014

Archives of Pathology &Amp; Laboratory Medicine

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Context.—Immunohistochemistry plays a vital role in the evaluation of breast pathology specimens. Objective.—To discuss the role of myoepithelial cell markers in the evaluation of various breast lesions. Other markers, such as E-cadherin and those used to differentiate mammary carcinoma from metastatic tumors to the breast, and markers used in the differential diagnosis of Paget disease, are also discussed. Data Sources.—Data were obtained from review of the pertinent peer-reviewed literature. Conclusions.—Myoepithelial cell markers vary in their sensitivity and specificity, and one should be aware of the potential pitfalls in interpretation. Using panels of 2 or more myoepithelial cell markers is always recommended, either singly or in cocktail forms. Although negative E-cadherin staining supports the diagnosis of lobular origin, positive staining does not rule it out. Immunohistochemistry can be helpful in differentiating Paget disease from its mimics. Although metastatic tumors to the breast are rare, a triple-negative immunophenotype and absence of an in situ component should be a “red flag” for such possibility, especially in patients with clinical history of an extramammary malignancy.

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“…Although this type of carcinoma has a good prognosis regardless of whether the tumor is diagnosed as in situ or invasive, there have been reports of metastasis to lymph nodes or distant organs [5,8,9].…”

Section: Introductionmentioning

confidence: 99%

“…However, preoperative differential diagnosis between intracystic papillary carcinomas vs. papillomas is very challenging even after needle biopsy, because of their nonspecific radiological characteristics, and subtle cytological and histological appearance. Hence, surgical excisional biopsy is recommended in the clinical management of these lesions, especially when associated with risk factors for malignancy, such as age (≥ 50 years) and the presence of microcalcifications [6][7][8]10]. A few papers have reported immunohistochemical techniques to be effective, but only in combination with other diagnostic techniques [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

A novel diagnostic method targeting genomic instability in intracystic tumors of the breast

et al. 2014

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Diagnostic difficulty arising from displaced epithelium after core biopsy in intracystic papillary lesions of the breast

Cited by 45 publications

References 6 publications

Intracystic Papillary Carcinoma of Breast Harbors Significant Genomic Alteration Compared with Intracystic Papilloma: Genome-wide Copy Number and LOH Analysis Using High-Density Single-Nucleotide Polymorphism Microarrays

Intracystic Papillary Carcinoma of Breast Harbors Significant Genomic Alteration Compared with Intracystic Papilloma: Genome-wide Copy Number and LOH Analysis Using High-Density Single-Nucleotide Polymorphism Microarrays

Diagnostic Role of Immunohistochemistry in the Evaluation of Breast Pathology Specimens

A novel diagnostic method targeting genomic instability in intracystic tumors of the breast

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