Diagnostic Difficulties in Woman with Crohn’s Disease, Ascites, and Elevated Value of Serum CA125 Antigen

Kłopocka, Maria; Liebert, Ariel; Bielińska, Joanna; Manerowski, M.

doi:10.1155/2014/981726

Cited by 3 publications

(2 citation statements)

References 22 publications

(31 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While we adjusted for these potential confounders in our study, the possibility of residual confounding remains. In contrast, the association we observed between higher CA125 and inflammatory bowel diseases among the postmenopausal women may be due to the inflammatory nature of these diseases as CA125 is known to increase in some inflammatory conditions of the gastrointestinal tract (37,43).…”

Section: Discussioncontrasting

confidence: 83%

Chronic Medical Conditions and CA125 Levels among Women without Ovarian Cancer

Akinwunmi

Babić

Vitonis

et al. 2018

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

Background: Randomized trials using the biomarker CA125, with or without pelvic ultrasound, have failed to show a clear benefit of general population screening for ovarian cancer. In part this may be due to a lack of information about conditions, besides ovarian cancer, that can alter CA125 levels and affect specificity or sensitivity. We evaluated the association between common medical conditions and CA125 levels among women without ovarian cancer. Methods: We used data and specimens from 2,004 women without ovarian cancer who participated in the New England Case Control study between 1992 and 2008. Participants completed in-person interviews and donated blood samples at enrollment. We measured CA125 using the CA125II assay and calculated the association between medical conditions and log-transformed CA125 using linear regression. Results: The median age of participants was 53 years and 1,119 (56%) were postmenopausal. The average CA125 level was 14.5 units/mL for premenopausal and 11.7 for postmenopausal women. Among premenopausal women, CA125 was significantly lower for women with colon polyps (p=0.06) and hysterectomy (p=0.01) and significantly higher with endometriosis (p=0.05). CA125 was also significantly higher in premenopausal women with coronary artery disease (CVD) (p<0.01, n=2 cases) but not among postmenopausal with CVD (n=79). Further, among postmenopausal women, CA125 was significantly lower for women with osteoporosis, hypercholesterolemia, and osteoarthritis (p=0.03, 0.02 and 0.01 respectively) and higher for women with a history of inflammatory bowel disease (p=0.04). Conclusion: Several chronic diseases are associated with CA125, which could influence the interpretation of CA125 in the context of ovarian cancer screening.

show abstract

Section: Discussioncontrasting

confidence: 83%

Chronic Medical Conditions and CA125 Levels among Women without Ovarian Cancer

Akinwunmi

Babić

Vitonis

et al. 2018

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

show abstract

“…Inflammatory markers could offer a novel approach to the diagnosis of this condition. Elevated levels of cancer antigen 125 (CA125) are frequently found in epithelial ovarian cancer; however, increased concentrations of this marker can also be detected in endometrioma, uterine leiomyoma, several types of inflammatory disease, and MCT . Another cancer antigen (CA19‐9) has a glycolipid structure and was initially found to be elevated in gastrointestinal adenocarcinomas, particularly those of the pancreas .…”

Section: Introductionmentioning

confidence: 99%