Diagnostic Cytopathology in Type II Angiosarcoma of the Breast

Angiosarcoma in FNA smears: diagnostic accuracy, morphology, immunocytochemistry and differential diagnoses

“…7 Some authors reported approximately 40% of their smears to be highly cellular. [7][8][9] Klijanienko et al 5 mentioned that epithelioid variants are generally more cellular than classic types, while Boucher et al 3 found the reverse to be true for his series.…”

“…They believe that cellularity is at least partly a reflection of aspiration technique 7 . Some authors reported approximately 40% of their smears to be highly cellular 7–9 . Klijanienko et al.…”

“…Breast angiosarcomas have been divided histologically into three categories according to the degree of differentiation because it has some prognostic value 21 . In FNA, low‐grade angiosarcoma of breast does not have obvious malignant features and mimics phyllodes tumour 8 and dermatofibrosarcoma protuberans, 12 while high‐grade tumours may be mistaken for adeno‐ or metaplastic carcinoma, melanoma 9 or other types of high‐grade sarcoma.…”

Spindle Cell Lesions of the Breast on Fine-Needle Aspiration Biopsy: A Miscellany of Masses

“…The cells have varying amounts of cytoplasm that may contain hemosiderin, intracytoplasmic lumens, or red cells and variable nuclear to cytoplasmic ratio. The nuclei are oval to elongate in shape with irregular nuclear contours, hyperchromasia, irregular chromatin, and prominent nucleoli [18, 24, 29, 30] (Fig. 6).…”

Liver

“…[131][132][133] angiosarcoma Angiosarcoma is an uncommon malignant tumor of endothelial cells that represents less than 1% of primary hepatic malignancies. 137 Positive immunoreactivity for endothelial markers such as CD34 136,[138][139][140] or CD31 136,141 is helpful in confirming the diagnosis and ruling out metastatic sarcomas, most commonly leiomyosarcoma. Like HCC, angiosarcoma is associated with cirrhosis; about one third of adult cases arise in this setting.…”