Diagnostic Criteria on 18F-FDG PET/CT for Differentiating Benign from Malignant Focal Hypermetabolic Lesions of Parotid Gland

Park, Soo Bin; Choi, Joon Young; Lee, Eun Jeong; Yoo, Jang; Cheon, Miju; Cho, Suk Kyong; Choe, Yearn Seong; Lee, Kyung Han; Kim, Byung Tae

doi:10.1007/s13139-012-0135-y

Cited by 17 publications

(9 citation statements)

References 14 publications

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“…Salivary gland tumors are rare, constituting about 3% of all head and neck carcinomas [1–3]. Most of these lesions originate from the parotid gland, with approximately 75% being benign [1].…”

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Is There a Role for PET/CT Parameters to Characterize Benign, Malignant, and Metastatic Parotid Tumors?

Kendi

Magliocca

Corey

et al. 2016

American Journal of Roentgenology

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OBJECTIVE Assessment of benign and malignant lesions of the parotid gland, including metastatic lesions, is challenging with current imaging methods. Fluorine-18 FDG PET/CT is a noninvasive imaging modality that provides both anatomic and metabolic information. Semiquantitative data obtained from PET/CT, also known as PET/CT parameters, are maximum, mean, or peak standardized uptake values (SUVs); metabolic tumor volume; total lesion glycolysis; standardized added metabolic activity; and normalized standardized added metabolic activity. Our aim was to determine whether FDG PET/CT parameters can differentiate benign, malignant, and metastatic parotid tumors. MATERIALS AND METHODS Thirty-four patients with parotid neoplasms underwent PET/CT before parotidectomy; maximum SUV, mean SUV, peak SUV, total lesion glycolysis, metabolic tumor volume, standardized added metabolic activity, and normalized standardized added metabolic activity were calculated on a dedicated workstation. Univariate analyses were performed. A ROC analysis was used to determine the ability of PET/CT parameters to predict pathologically proven benign, malignant, and metastatic parotid gland neoplasms. RESULTS Fourteen patients had a benign or malignant primary parotid tumor. Twenty had metastases to the parotid gland. When the specificity was set to at least 85% for each parameter to identify cut points, the corresponding sensitivities ranged from 15% to 40%. Assessment of benign versus malignant lesions of parotid tumors, as well as metastasis from squamous cell carcinoma versus other metastatic causes, revealed that none of the PET/CT parameters has enough power to differentiate among these groups. CONCLUSION PET/CT parameters, including total lesion glycolysis, metabolic tumor volume, standardized added metabolic activity, and normalized standardized added metabolic activity, are not able to differentiate benign from malignant parotid tumors, primary parotid tumors from metastasis, or metastasis from squamous cell carcinoma and nonsquamous cell carcinoma metastasis.

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“…Although most parotid tumors are glandular in cause, squamous cell carcinoma represents most FDG-avid head and neck tumors overall [2]. The controversy surrounding the role of FDG PET/CT in the assessment of parotid tumors results from the fact that some malignant tumors present as non-FDG-avid lesions [2, 3, 7]. …”

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Is There a Role for PET/CT Parameters to Characterize Benign, Malignant, and Metastatic Parotid Tumors?

Kendi

Magliocca

Corey

et al. 2016

American Journal of Roentgenology

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“…Imaging techniques established the site of origin of these tumors with 96% accuracy 14 . Prior to the CT era, very limited radiologic information could be gleaned from plain films and multidirectional tomograms 15 . The degree of lesion vascularity could be identified on a conventional angiogram; however, only a lesion such as a paraganglioma, with its characteristic hypervascular appearance, or an aneurysm could be confidently diagnosed 12 .…”

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CT-Scan Evaluation for the Detection of Benign Parapharyngeal Mass

Alim¹,

Ahmed²,

Haque³

et al. 2022

J. Natl Inst. Neurosci Bangladesh

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Background: Detection of benign parapharyngeal mass is very crucial for the management of the patients. Objective: The purpose of the present study was to evaluate the CT scan for the detection of benign parapharyngeal mass. Methodology: This cross-sectional study was carried out in the Department of Radiology and Imaging at Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh from July 2009 to April 2011 for a period of around two years. All the clinically suspected cases of parapharyngeal space mass lesions attended in the Otolaryngology and Radiology & Imaging department of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka were enrolled in this study. The patient in this study was evaluated according to the management plan for surgery followed in Otolaryngology department. The histopathology was performed by the histopathologist of the Department of Pathology at BSMMU, Dhaka, Bangladesh. All patients were undergone CT examination of neck and the comparison of the findings was done with the histopathology results. Result: A total number of 50 patients were recruited for this study after fulfilling the inclusion and exclusion criteria. Mean (±SD) age of the patients was 37.76 (±14.82). Sensitivity of CT to diagnose benign parapharyngeal mass was 92.1%, specificity 83.3%, positive predictive value 94.6%, negative predictive value 76.9% and accuracy 90.0%. The area under the curve value was calculated and was found 0.142 (95% CI 0.000 to 0.286) (p=0.000). Conclusion: In conclusion the sensitivity and specificity of CT scan for the detection of benign parapharyngeal mass lesion is very high. Journal of National Institute of Neurosciences Bangladesh, July 2021, Vol. 7, No. 2, pp. 118-121

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“…Therefore, in case of high-grade SGT, cervical LN staging needs more sensitive diagnostic modality, and FDG PET/CT may be helpful. It is difficult to distinguish between benign and malignant SGT on F-18 FDG PET/CT because benign tumors such as Warthin's tumor may also show high glucose metabolism [19][20][21]. However, recent studies have demonstrated that F-18 FDG PET/CT has a significant effect on the management of patients with malignant SGT in initial staging and followup compared with conventional imaging studies [6,[11][12][13].…”

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confidence: 99%

The Value of F-18 FDG PET for Planning Treatment and Detecting Recurrence in Malignant Salivary Gland Tumors: Comparison with Conventional Imaging Studies

Park

Yoo

Lee

et al. 2013

Nucl Med Mol Imaging

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Diagnostic Criteria on 18F-FDG PET/CT for Differentiating Benign from Malignant Focal Hypermetabolic Lesions of Parotid Gland

Abstract: Uptake patterns and margins on CT are useful PET/CT diagnostic criteria for differentiating benign from malignant lesions.

Cited by 17 publications

References 14 publications

Is There a Role for PET/CT Parameters to Characterize Benign, Malignant, and Metastatic Parotid Tumors?

Is There a Role for PET/CT Parameters to Characterize Benign, Malignant, and Metastatic Parotid Tumors?

CT-Scan Evaluation for the Detection of Benign Parapharyngeal Mass

The Value of F-18 FDG PET for Planning Treatment and Detecting Recurrence in Malignant Salivary Gland Tumors: Comparison with Conventional Imaging Studies

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