Diagnostic criteria for acute‐onset type 1 diabetes mellitus (2012): Report of the <scp>C</scp>ommittee of <scp>J</scp>apan <scp>D</scp>iabetes <scp>S</scp>ociety on the <scp>R</scp>esearch of <scp>F</scp>ulminant and <scp>A</scp>cute‐<scp>o</scp>nset <scp>T</scp>ype 1 <scp>D</scp>iabetes <scp>M</scp>ellitus

Kawasaki, Eiji; Maruyama, Taro; Imagawa, Akihisa; Awata, Takuya; Ikegami, Hiroshi; Uchigata, Yasuko; Osawa, Haruhiko; Kawabata, Yumiko; Kobayashi, Tetsuro; Shimada, Akira; Shimizu, Ikki; Takahashi, Kazuma; Nagata, Michio; Makino, Hideichi; Hanafusa, Toshiaki

doi:10.1111/jdi.12119

Cited by 89 publications

(96 citation statements)

References 13 publications

(16 reference statements)

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“…T1D is considered to be an organ-specific autoimmune disorder, and many patients with acute-onset T1D, similarly to those with slowly progressive T1D, have autoantibodies against islet antigens in the early phase of the disease (5, 6, 9); these are typically referred to as autoimmune cases. The major autoantibodies of clinical and research interest include ICA, GADA, insulinoma-associated antigen-2 antibody, insulin autoantibody, and ZnT8 antibody; however, the sensitivity of each marker is still less than 80% (30), and a subset of patients with acute-onset T1D are autoantibody-negative (idiopathic cases) (9). In addition, if present, these autoantibody titers may decline and even disappear over time (30).…”

Section: Discussionmentioning

confidence: 99%

“…It is a complex, heterogeneous disease, and depending on the manner of onset and progression, T1D is classified as acute-onset ("classical"), slowly progressive, or fulminant in Japan (5)(6)(7)(8)(9). Acute-onset T1D is characterized by the presence of diabetic ketoacidosis (DKA) at the time of diagnosis (clinical onset) and a lifelong insulin-dependent state thereafter.…”

Section: Introductionmentioning

confidence: 99%

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Type 1 Diabetes Mellitus and Pernicious Anemia in an Elderly Japanese Patient: A Case Report and Literature Review

et al. 2015

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We herein report the case of a 66-year-old Japanese man with acute-onset type 1 diabetes mellitus (T1D) accompanied by pernicious anemia. After 2 weeks of polyuria, the patient developed insulin-deficient hyperglycemia with diabetic ketoacidosis in the absence of verifiable islet-related autoantibodies and began insulin therapy in 2001. Eight years later, he developed gastric autoantibody-positive pernicious anemia and began methylcobalamin treatment. Previous studies have reported cases of slowly progressive autoimmune T1D concomitant with pernicious anemia. The present case suggests that potential associations with organ-specific autoimmune disorders should be considered during the long-term follow-up of T1D patients, even though verifiable islet-related autoantibodies are undetectable.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Type 1 Diabetes Mellitus and Pernicious Anemia in an Elderly Japanese Patient: A Case Report and Literature Review

et al. 2015

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“…6,7) Fulminant type 1 diabetes (FT1D) is a subtype of type 1 diabetes characterized by the abrupt onset of insulin-deficient hyperglycemia and ketoacidosis within a few days. Most patients have been identified from East Asia, particularly Japan, and infrequently from other regions or Caucasians.…”

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confidence: 99%

Fulminant Type 1 Diabetes Mellitus and Fulminant Viral Myocarditis

et al. 2015

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SummaryA 35-year-old Japanese woman was admitted with coma following flu-like symptoms. She was diagnosed with diabetic ketoacidosis and fulminant type 1 diabetes (FT1D) and received intravenous infusion of insulin and saline. The next day, the ketoacidosis disappeared, and she recovered consciousness. However, extensive ST-segment elevations in the electrocardiogram appeared with a positive troponin test, and the patient developed pulmonary edema on day 3. An echocardiogram showed globally reduced wall motion of the left ventricle and mild pericardial effusion. Despite medical therapy with intravenous furosemide, carperitide, and catecholamines, her cardiac function deteriorated rapidly, with the left ventricular ejection fraction decreasing to 26% within 7 hours, and progressed to cardiogenic shock that afternoon. The patient received mechanical circulatory support for 4 days with intra-aortic balloon pumping and percutaneous cardiopulmonary support, and recovered fully from circulatory failure. A paired serum antibody test showed a significantly elevated titer against parainfluenza-3 virus, indicating a diagnosis of fulminant viral myocarditis. She was discharged on multiple daily insulin injection therapy, and her subsequent clinical course has been uneventful. In summary, we present a case of concurrent FT1D and fulminant viral myocarditis. Parainfluenza-3 viral infection was confirmed serologically and was considered to be a cause of both the FT1D and fulminant myocarditis. (Int Heart J 2015; 56: 239-244)

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“…Therefore, the presenting case would be diagnosed as acute-onset T1D [4] based on a high titer of GAD antibody and the time taken for onset of symptoms. Although it is unknown when GAD antibody converted to be positive in this case, the patient is hypothesized to newly develop T1D induced by IFNα, considering the clinical course.…”

Section: Discussionmentioning

confidence: 99%

Diabetic Ketoacidosis Due to Type 1 Diabetes Mellitus Induced by Interferon Therapy for Chronic Hepatitis C During the Course of Hashimoto’s Thyroiditis: Case Report

Jo¹,

Iwase²,

Nishizawa³

et al. 2017

Diabetes Case Rep

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Interferon α (IFNα) has been reported to induce several autoimmune diseases, including autoimmune thyroiditis (AITD) and type 1 diabetes (T1D). In addition, co-occurrence of T1D and AITD is well known as one of the variants of the autoimmune polyglandular syndrome type 3. Meanwhile, there are no reports about the risk of development of IFN treatment-related T1D in patients with previously diagnosed AITD. We present a single case report about a 61-yearold Japanese woman with Diabetic Ketoacidosis (DKA) three months after the initiation of the combination therapy with peginterferon α-2b and ribavirin for chronic hepatitis C. She was diagnosed with T1D owing to severely impaired insulin secretion along with DKA and presence of positive GAD antibody. Her T1D was supposed to be induced by IFN therapy. She had received the replacement therapy for hypothyroidism resulting from Hashimoto's thyroiditis for 30 years. The patient had human leukocyte antigens (HLA), DRB1*04:05 and DQB1*04:01, which are associated with a genetic predisposition for T1D and AITD. Patients with previously diagnosed AITD are assumed to be at high risk for IFN treatment-related T1D because most patients with T1D triggered by IFN were reported to have genetic susceptibilities similar to those with classical T1D and AITD. In conclusion, patients with known AITD should be carefully monitored for their glycemic condition to avoid life-threatening events such as DKA when they receive IFN therapy.

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Diagnostic criteria for acute‐onset type 1 diabetes mellitus (2012): Report of the Committee of Japan Diabetes Society on the Research of Fulminant and Acute‐onset Type 1 Diabetes Mellitus

Cited by 89 publications

References 13 publications

Type 1 Diabetes Mellitus and Pernicious Anemia in an Elderly Japanese Patient: A Case Report and Literature Review

Type 1 Diabetes Mellitus and Pernicious Anemia in an Elderly Japanese Patient: A Case Report and Literature Review

Fulminant Type 1 Diabetes Mellitus and Fulminant Viral Myocarditis

Diabetic Ketoacidosis Due to Type 1 Diabetes Mellitus Induced by Interferon Therapy for Chronic Hepatitis C During the Course of Hashimoto’s Thyroiditis: Case Report

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