Diagnostic criteria and histologic grading in multiple myeloma: Histologic and immunohistologic analysis of 176 cases with clinical correlation

Sukpanichnant, Sanya; Cousar, John B.; Leelasiri, Apichai; Gräber, Stanley E.; Greer, John P.; Collins, Robert D.

doi:10.1016/0046-8177(94)90204-6

Cited by 67 publications

(62 citation statements)

References 39 publications

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“…Based on the CD138 staining in the 79 cases with multiple myeloma included in the study, we identified 4 distinct morphologic patterns of plasma cell distribution, similar to what was reported in previous studies using κ and λ light chain IHC [1]. These included interstitial patterns, micro-aggregates, large nodules, and diffuse patterns (Fig.…”

Section: Patterns Of Plasma Cell Distribution and Cellular Stainingsupporting

confidence: 70%

“…Of importance, it provides information on the level of bone marrow involvement by plasma cells in these disorders. The percentage of plasma cells in the bone marrow, based on the examination of aspirate smears, is one of the criteria used for the diagnosis of multiple myeloma [1,2]. Plasma cell quantitation is also used in evaluating morphologic remission [3] and minimal residual disease in patients with this disease [4].…”

Section: Introductionmentioning

confidence: 99%

“…The advent of antibody staining has enabled the identification of plasma cells in bone marrow sections with greater specificity than HE stains, an advance that has led to more frequent use of bone marrow sections in the diagnosis and follow-up of multiple myeloma [1,6,11,14,15]. Bone marrow involvement by malignant plasma cells is often focal, more akin to that seen with lymphomas or metastatic tumors than leukemias.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of bone marrow plasma cell infiltrates in multiple myeloma: the added value of CD138 immunohistochemistry

et al. 2007

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SummaryAssessment of bone marrow involvement by malignant plasma cells is an important element in the diagnosis and follow-up of patients with multiple myeloma and other plasma cell dyscrasias. Microscope-based differential counts of bone marrow aspirates are used as the primary method to evaluate bone marrow plasma cell percentages. However, multiple myeloma is often a focal process, a fact that impacts the accuracy and reliability of the results of bone marrow plasma cell percentages obtained by differential counts of bone marrow aspirate smears. Moreover, the interobserver and intraobserver reproducibility of counting bone marrow plasma cells microscopically has not been adequately tested. CD138 allows excellent assessment of plasma cell numbers and distribution in bone marrow biopsies. We compared estimates of plasma cell percentages in bone marrow aspirates and in hematoxylin-eosin-and CD138-stained bone marrow biopsy sections (CD138 sections) in 79 bone marrows from patients with multiple myeloma. There was a notable discrepancy in bone marrow plasma cell percentages using the different methods of observation. In particular, there was a relatively poor concordance of plasma cell percentage estimation between aspirate smears and CD138 sections. Estimates of plasma cell percentage using CD138 sections demonstrated the highest interobserver concordance. This observation was supported by computer-assisted image analysis. In addition, CD138 expression highlighted patterns of plasma cell infiltration indicative of neoplasia even in the absence of plasmacytosis. We conclude that examination of CD138 sections should be considered for routine use in the estimation of plasma cell load in the bone marrow.

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Section: Patterns Of Plasma Cell Distribution and Cellular Stainingsupporting

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Assessment of bone marrow plasma cell infiltrates in multiple myeloma: the added value of CD138 immunohistochemistry

et al. 2007

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“…Le MM comporte trois variétés histopathologiques (plasmocytaire, anaplasique et plasmoblastique) qui ont une valeur pronostique. La variété plasmoblastique, la plus rare (2 % des cas), possède un mauvais pronostic : la survie sans traitement est d'environ huit mois [9][10][11][12].…”

Section: Douleurs Osseusesunclassified

“…L'examen histopathologique de la biopsie-aspiration de la lésion mandibulaire confirme le diagnostic de plasmocytome plasmoblastique, variété histologique de mauvais pronostic [12,14] (Fig. 8a).…”

Section: Diagnostic Et Pronosticunclassified

Plasmocytome mandibulaire révélateur d’un myélome multiple. Présentation d’un cas

Urbina

Flores

Salvador

et al. 2010

Med Buccale Chir Buccale

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Key words: plasmocytoma / multiple myeloma / oral pathology Abstract -Mandibular plasmocytoma leading to the discovery of a multiple myeloma. Report of a case. Plasmacytoma is considered as the initial presentation of multiple myeloma (MM), a devastating and fatal disease. MM is more frequent in men (male-female ratio = 4:1) and generally occurs between the 5th and the 8th decade, affecting with greater frequency vertebrae, skull, pelvic bones, ribs, humerus and femur. According to the WHO, in 2002, MM was the 17th cause of death by neoplasms in the world. We report a case of a 30-year-old woman, referred to the Maxillofacial surgery pregraduate school of the Faculty of Odontology of national autonomous University (Mexico) for a swelling of her left jaw, with an initial diagnosis of infection, and later histopathologically diagnosed as a plasmacytoma. A complete work-up including blood tests, urine tests and total-body x-rays led to a definitive diagnosis of MM, with a rare histologic profile, considered to be having a poor prognosis. The patient was subjected to chemotherapy but she passed away five months later. This case represents one of those undiagnosed cases of malignant neoplasms, considered first as an unsuspected infective lesion and treated as such with antibiotic therapy. The case also highlights the role that could be played by the dental profession in the early diagnosis of bone cancers, which often have a poor prognosis.Le MM est une néoplasie maligne développée à partir des lymphocytes B, caractérisée par une prolifération de plasmocytes

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Waldenstr�m's macroglobulinemia

Andriko

Aguilera

Chu

et al. 1997

Cancer

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Diagnostic criteria and histologic grading in multiple myeloma: Histologic and immunohistologic analysis of 176 cases with clinical correlation

Cited by 67 publications

References 39 publications

Assessment of bone marrow plasma cell infiltrates in multiple myeloma: the added value of CD138 immunohistochemistry

Assessment of bone marrow plasma cell infiltrates in multiple myeloma: the added value of CD138 immunohistochemistry

Plasmocytome mandibulaire révélateur d’un myélome multiple. Présentation d’un cas

Waldenstr�m's macroglobulinemia

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