Diagnostic contribution of quantitative analysis of salivary scintigraphy in patients with suspected Sjögren's syndrome

Infante, J.R.; García, Luis Ruiz; Rayo, J.I.; Serrano, J.; Domínguez, M.L.; Moreno, M.

doi:10.1016/j.remnie.2016.03.002

Cited by 2 publications

(8 citation statements)

References 24 publications

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“…In addition, EF% results were not different between groups except for those relating to the right submandibular values. This is in accordance with a report by Nishiyama et al (11), who found no differences in parotid EF% between SS and controls, and with the studies by Infante et al (30) and Kim et al (33), in which asymmetrical involvement with right-sided predominance was also found. We agree with the fact that, as described by these authors, random probability might explain this uneven involvement.…”

Section: Discussionsupporting

confidence: 93%

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The validity of salivary gland scintigraphy in Sjögren’s syndrome diagnosis: comparison of visual and excretion fraction analyses

García-González

González-Soto

Rodríguez-Bethencourt

et al. 2020

Clin Rheumatol

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Introduction. The diagnostic value of salivary gland scintigraphy (SGS) in Sjögren's syndrome (SS) is not completely known. Whether qualitative or quantitative methods of SGS interpretation are the most appropriate remains a matter of debate. We sought to determine whether the diagnostic discrimination of quantitative excretion fraction is higher compared to SGS qualitative visual analysis in a cohort of subjects with suspected SS. Materials and methods. Cross-sectional study that encompassed 204 subjects who underwent SGS for potential SS diagnosis. Based on clinical judgement, three groups were established: SS, non-SS autoimmune diseases (AID non-SS) and neither SS nor other AID (non-AID). In addition, American-European Consensus Group -AECG-and American College of Rheumatology -ACR-criteria were applied. Qualitative diagnosis through visual analysis -normal vs. abnormal and Schall's classi cation grade-and semiquantitative and quantitative excretion fraction (EF%) scores were established following SGS assessment. The diagnostic discrimination of the different SGS scores for the various SS diagnostic modalities (clinical judgement and AECG and ACR criteria) was compared through their areas under the curve (AUC).Results. Most SGS parameters were signi cantly associated with SS-related clinical and laboratory features. Schall's grade ≥ III was signi cantly more frequent in SS than in non-SS patients. In general, EF%-derived parameters did not show signi cant differences between groups. AUC of Schall's classi cation reached statistical signi cance in its diagnostic discrimination for SS clinical judgement (AUC 0.704 [95%CI 0.597-0.811], p = 0.000) and AECG criteria (AUC 0.764 [95%CI 0.641-0.886], p = 0.000). Similarly the EF% submandibular mean (AUC 0.737 [95%CI 0.546-0.931] p = 0.032) was signi cantly associated with SS diagnosis through ACR criteria. However, AUC comparisons between qualitative and quantitative methods did not yield signi cant values.Conclusion. SS diagnostic discrimination of EF% is not superior to that obtained by qualitative visual analysis.

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Section: Discussionsupporting

confidence: 93%

Section: Salivary Gland Scintigraphy Resultsmentioning

confidence: 99%

The validity of salivary gland scintigraphy in Sjögren’s syndrome diagnosis: comparison of visual and excretion fraction analyses

García-González

González-Soto

Rodríguez-Bethencourt

et al. 2020

Clin Rheumatol

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“…In a study by Vinagre et al, a Schall's grade ≥ III yielded an S and E of 75% and 78%, respectively, compared to the 68% and 84% gures obtained with our sample (36). In the study by Infante et al, although S reached 89% and E 100%, discrimination was calculated between SS patients and healthy subjects, and not between SS patients and other forms of sicca syndrome and/or autoimmune diseases (30). In any case, and in line with what has been identi ed by Kim et al (33), the best performances of the EF%-derived parameters in our sample were only moderate and their e ciencies, once the cut-off points were established, were not superior to that of a Schall's grade ≥ III.…”

Section: Discussioncontrasting

confidence: 45%

“…Concerning EF%-derived parameters, although SS patients presented, in general, lower EF% values, differences were only signi cant in the comparison of SS and non-AID groups for the right submandibular gland (27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41) Salivary gland scintigraphy data in discriminating patients with Sjögren's syndrome Table 4 shows the receiver operating curve (ROC) analyses of different SGS modalities according to various SS diagnostic criteria. In this sense, the AUCs for SGS visual analysis, both for presence of abnormalities and Schall's classi cation, reached statistical signi cance in their discrimination for the SS clinical judgement (Schall's classi cation AUC 0.704 [95%CI 0.597-0.811], p = 0.000) and AECG criteria (Schall's classi cation AUC 0.764 [95%CI 0.641-0.886], p = 0.000).…”

Section: Salivary Gland Scintigraphy Resultsmentioning

confidence: 99%

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The Validity of Salivary Gland Scintigraphy in Sjögren’s Syndrome Diagnosis: Comparison of Visual and Excretion Fraction Analysis

García-González

Soto

Rodríguez-Bethencourt

et al. 2020

Preprint

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Introduction. The diagnostic value of salivary gland scintigraphy (SGS) in Sjögren’s syndrome (SS) is not completely known. Whether qualitative or quantitative methods of SGS interpretation are the most appropriate remains a matter of debate. We sought to determine whether the diagnostic discrimination of quantitative excretion fraction is higher compared to SGS qualitative visual analysis in a cohort of subjects with suspected SS. Materials and methods. Cross-sectional study that encompassed 204 subjects who underwent SGS for potential SS diagnosis. Based on clinical judgement, three groups were established: SS, non-SS autoimmune diseases (AID non-SS) and neither SS nor other AID (non-AID). In addition, American-European Consensus Group -AECG- and American College of Rheumatology -ACR- criteria were applied. Qualitative diagnosis through visual analysis -normal vs. abnormal and Schall’s classification grade- and semiquantitative and quantitative excretion fraction (EF%) scores were established following SGS assessment. The diagnostic discrimination of the different SGS scores for the various SS diagnostic modalities (clinical judgement and AECG and ACR criteria) was compared through their areas under the curve (AUC). Results. Most SGS parameters were significantly associated with SS-related clinical and laboratory features. Schall’s grade ≥ III was significantly more frequent in SS than in non-SS patients. In general, EF%-derived parameters did not show significant differences between groups. AUC of Schall’s classification reached statistical significance in its diagnostic discrimination for SS clinical judgement (AUC 0.704 [95%CI 0.597–0.811], p = 0.000) and AECG criteria (AUC 0.764 [95%CI 0.641–0.886], p = 0.000). Similarly the EF% submandibular mean (AUC 0.737 [95%CI 0.546–0.931] p = 0.032) was significantly associated with SS diagnosis through ACR criteria. However, AUC comparisons between qualitative and quantitative methods did not yield significant values. Conclusion. SS diagnostic discrimination of EF% is not superior to that obtained by qualitative visual analysis.

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Recent Advances in Salivary Scintigraphic Evaluation of Salivary Gland Function

Chen

Hsu

2021

Diagnostics

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Saliva plays an important role in supporting upper gastrointestinal tract function and oral well-being. Salivary dysfunction mainly manifests with a decrease in salivary flow. Among varieties of quantitative methods, salivary scintigraphy is a relatively noninvasive, well-tolerated, reproducible, and objective approach for functional evaluation of salivary disorders, yet the lack of precise quantitative reference values and no standardized protocol limit its generalized utilization. In this article, we review the scintigraphic performance between the visual analysis and quantitative methods in predicting Sjögren’s syndrome and verify the potential aspects of the application in interpreting different disease entities and phases of functional salivary disorders.

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Diagnostic contribution of quantitative analysis of salivary scintigraphy in patients with suspected Sjögren's syndrome

Cited by 2 publications

References 24 publications

The validity of salivary gland scintigraphy in Sjögren’s syndrome diagnosis: comparison of visual and excretion fraction analyses

The validity of salivary gland scintigraphy in Sjögren’s syndrome diagnosis: comparison of visual and excretion fraction analyses

The Validity of Salivary Gland Scintigraphy in Sjögren’s Syndrome Diagnosis: Comparison of Visual and Excretion Fraction Analysis

Recent Advances in Salivary Scintigraphic Evaluation of Salivary Gland Function

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