Diagnostic considerations in central odontogenic fibroma of the maxilla: 2 case reports

Abstract

Central odontogenic fibroma (COF) is defined as a fibroblastic odontogenic tumor characterized by varying density of the tooth epithelium. It is an extremely rare benign neoplasm that occurs in the maxilla and the mandible; only a few reports of COF are available in the literature. Diagnosis of the lesion based only on the radiological features of COF is difficult due to variation in the findings regarding this condition. This report describes 2 clinical cases of middle-aged women with COF. Clinical examination revealed palatal mucosal depression; additionally, oral examination, as well as panoramic radiographs, intraoral radiographs, and computed tomography scans, revealed severe root resorption. This report highlights the clinical and radiological imaging features of COF, with the goal of enabling straightforward differential diagnosis of the lesion by the clinician and thereby appropriate treatment of the patient.

Central odontogenic fibroma of simple type: An original observation

“…13 Immunohistochemical staining or ultrastructure analysis cannot distinguish between the 2 types of COF. 5 As for our case, small nests of odontogenic epithelium that appeared entirely inactive were present in minimal amounts. There was a preponderance of fibrosis with some sparse calcifications.…”

“…4 However, recent scientific publications still mention this sub-classification. According to Seo et al, 5 investigators should consider that any single COF entity may exhibit the 2 different histological patterns.…”

Central odontogenic fibroma, hyperplastic dental follicle, or dentigerous cyst? A diagnostic dilemma: A case report

“…Central odontogenic fibroma is a rare benign neoplasm of the jaw bones, accounting for less than 0.1% of all odontogenic tumors. COF composed of varying amounts of inactive odontogenic epithelium embedded in a neoplastic mature and fibrous stroma 1–3 . The lesion may evolve from dental follicle 4,5 .…”

“…Radiographically, smaller tumors are well‐defined unilocular radiolucent lesions. Approximately 12% of COFs will show radiopaque flecks within the lesion 2 . Formerly, solid fibrous masses that were associated with the crown of an unerupted tooth classified as COF.…”

“…COF composed of varying amounts of inactive odontogenic epithelium embedded in a neoplastic mature and fibrous stroma. 1 , 2 , 3 The lesion may evolve from dental follicle. 4 , 5 COFs occur in different ages ranged from 4 to 80.…”