Diagnostic Clue in a Neonate with Amniotic Band Sequence

Abstract

Amniotic band syndrome (ABS) is a set of congenital malformations that mainly affect the limbs and more rarely the skull, face, chest, and abdomen. Two main hypotheses have been proposed to explain the nature of the disorder: an intrinsic and extrinsic factor. We report a newborn with ABS presenting with several malformations involving both hands and foot. In this case, the malformative event localized at the hands and right foot without involvement of any other internal organs and is asymmetric which leads us to suppose the extrinsic factor as cause of the ABS.

Direct visualization of the evolution of limb amputation in amnion rupture sequence in an extremely preterm infant born at 22 weeks

“…In honor of Professor Graham's critical insights, we will refer to this condition as ARS in the remainder of this article. Various body parts including limbs, the body wall, the craniofacial region, and the viscera can be affected either directly by disruption through bands or indirectly through mechanical compression (Falsaperla et al, 2020). Several theories on the etiology of ARS, including intrinsic theory (Streeter, 1930), extrinsic theory (Torpin, 1965), germinal disc or ectodermal damage (Hunter et al, 2011), and vascular damage (Van Allen et al, 1987) have been proposed.…”

“…Treatment is palliative, and the long-term outcome is variable (Falsaperla et al, 2020). The risk of recurrence is usually low (Levy et al, 2007).…”