Diagnostic challenges in tuberculous meningitis: a case report with negative genexpert result

Abstract

Introduction: Tuberculous meningitis (TBM) is a severe form of tuberculosis affecting the meninges, primarily caused by Mycobacterium tuberculosis. Diagnosis of TBM poses numerous challenges due to its non-specific clinical presentation and the limitations of diagnostic tests like GeneXpert. Case presentation: We report a case of a 22-year-old female from Eastern Nepal presenting with acute onset fever, headache, vomiting, and neck pain. CSF analysis showed lymphocytic pleocytosis, elevated protein, low glucose levels, and cobweb coagulum indicative of TBM. However, the GeneXpert test revealed negative results. Discussion: In resource-limited settings like Nepal, where access to GeneXpert MTB/Rif is limited, CSF analysis and clinical algorithms play a crucial role in diagnosing tuberculous meningitis (TBM). Relying solely on GeneXpert results may lead to false negatives, so a high level of suspicion based on patient risk factors is essential. Prompt initiation of empirical anti-tubercular therapy is vital for a favorable outcome in TBM cases. Conclusion: Negative MTB PCR results from CSF can be misleading in diagnosis of Tubercular meningitis. Therefore, comprehensive evaluations, including detailed patient history, physical examination, and CSF fluid analysis, are crucial in high TB prevalence countries to ensure accurate and timely diagnosis.