Diagnostic challenge of perimenopause molar pregnancy in a 52-year-old lady: Case report

Kyejo, Willbroad; Rubagumya, Davis; Ntiyakuze, Gregory; Matillya, Nancy; Kaguta, Munawar; Mgonja, Miriam; Moshi, Lynn

doi:10.1016/j.ijscr.2022.107648

Cited by 2 publications

(6 citation statements)

References 16 publications

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“…In 30% cases, by the time of final diagnosis, metastasis would have already occurred. 5 In our case series, brain metastasis was seen in three cases, lung metastasis was seen in three cases, one case had multiorgan metastasis that had worse prognosis and succumbed to the disease, and two cases had no metastasis.…”

Section: Discussionmentioning

confidence: 53%

“…It usually occurs 50% of cases after hydatidiform mole, 25% cases after spontaneous abortion, 22.5% after normal pregnancy, and 2.5% after ectopic gestation. 5 In our case series, out of six cases, three cases were after vaginal delivery that is difficult to diagnose as they present with abnormal uterine bleeding (either amenorrhea, irregular vaginal bleeding or persistent vaginal bleeding) and present to the hospital late. Two cases were after abortion where products were not sent for HPR, so it might have been a type of molar pregnancy that needed follow-up.…”

Section: Discussionmentioning

confidence: 79%

“…In such cases, it is difficult to say whether the antecedent pregnancy led to choriocarcinoma. 5 Choriocarcinoma after nonmolar pregnancy is associated with worse outcomes due to delay in diagnosis and widespread metastatic disease, increased interval between onset of disease, and previous pregnancy. 6 In our case series, all were after nonmolar pregnancies and in that four had metastatic disease.…”

Section: Discussionmentioning

confidence: 99%

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A Case Series of Gestational Choriocarcinoma with Review of Literature

Tanneru,

Shetty,

Nandan

2023

Indian J Med Paediatr Oncol

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Choriocarcinoma can be gestational and nongestational. Gestational choriocarcinoma is rare with an incidence of 9.2 in 40,000 pregnancies in Asian population. They can occur following molar, partial molar pregnancy, abortion, or delivery. It is detected by elevated levels of serum beta-human chorionic gonadotropin (beta-hCG) and by imaging modality. The need for histopathological diagnosis for choriocarcinoma is debatable. Six cases of choriocarcinoma are described with variable presentations and outcomes. Out of six cases, three were following vaginal delivery, two were after abortion, and one case was perimenopausal with antecedent pregnancy 10 years ago, unclear whether it was the cause for choriocarcinoma. Brain and lung metastasis were seen in three cases each; one case, which had metastasis to all organs, had worse prognosis and succumbed to the disease. All belonged to high-risk group according to International Federation of Gynaecology and Obstetrics score (8–13). The prognosis is usually very good, provided that prompt diagnosis and treatment are initiated early. Long-term follow-up with beta-hCG levels needs to be done to detect recurrence but it did not act like a prognostic indicator in our case series.

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Section: Discussionmentioning

confidence: 53%

Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

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A Case Series of Gestational Choriocarcinoma with Review of Literature

Tanneru,

Shetty,

Nandan

2023

Indian J Med Paediatr Oncol

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“…Therefore, it may be reasonable to assess for GTD even in perimenopausal women with abnormal uterine bleeding. [13] .…”

Section: Discussionmentioning

confidence: 99%

“…It must be personalized to ensure the patient's compliance. Although, breast cancer women over 50 years rarely become pregnant, GTD should be taken into account in the differential diagnosis of pre- and postmenopausal abnormal vaginal bleeding [13] .…”

Section: Discussionmentioning

confidence: 99%