Diagnostic Capability of Optical Coherence Tomography (Stratus OCT 3) in Early Glaucoma

Parikh, Rajul; Parikh, Shefali; Sekhar, G. Chandra; Kumar, Rajesh S.; Prabakaran, S.; Jonnadula, Ganesh Babu; Thomas, Ravi

doi:10.1016/j.ophtha.2007.03.005

Cited by 104 publications

(68 citation statements)

References 22 publications

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“…Our results show higher sensitivity (83%), but nearly same specificity (89.4%) for our best OCT parameter (inferior average) than most earlier studies. 2,27 Brusini et al 2 showed that the best performing indices for the GDx VCC and OCT gave similar AROCs. In our study, NFI of GDx has better discrimination than inferior average of OCT.…”

Section: Discussionmentioning

confidence: 98%

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Relationship between GDx VCC and Stratus OCT in juvenile glaucoma

Zareii

Soleimani

Moghimi

et al. 2009

Eye

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Purpose To compare the ability of scanning laser polarimetry (GDx VCC) and optical coherence tomography (OCT) to discriminate eyes with juvenile glaucoma from normal eyes and to assess the relationship between their parameters. Methods A total of 24 glaucomatous eyes of 24 patients and 24 normal eyes were enrolled. The age range of the patient was 11-40 years with a mean age of 25.1 ± 8.2 years. Contol groups consisted 24 eyes of 24 individuals without glaucoma with a mean age of 33.2 ± 8.2 years. All subjects underwent a full ophthalmic examination, automated perimetry, GDx VCC, and OCT. Correlation coefficients between the parameters of OCT and GDx VCC were calculated. We calculated the area under the receiver operating characteristic curve (AROC) for the main parameters of GDx VCC and OCT.

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Section: Discussionmentioning

confidence: 98%

“…Earlier studies show that OCT and GDx have moderate sensitivity with high specificity for the diagnosis of early glaucoma. 2,27 Most of these studies were on early glaucoma that had small, localised RNFL thickness. One reason for our better results might be that we did not exclude patients with advanced juvenile glaucoma.…”

Section: Discussionmentioning

confidence: 99%

Relationship between GDx VCC and Stratus OCT in juvenile glaucoma

Zareii

Soleimani

Moghimi

et al. 2009

Eye

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“…Circumpapillary RNFL (CpRNFL) measurement using OCT is a widely accepted clinical technique for assessing glaucoma. [1][2][3] Recently, spectral domain OCT (SD-OCT) with high scan speed and resolution has made regional RNFL imaging and quantitative analysis of a broader area possible. [4][5][6] Regional RNFL imaging provides topographic thickness information, so a quantitative analysis of the RNFL thickness map is expected to have potential advantages in detecting localized RNFL defects.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic ability of retinal nerve fiber layer maps to detect localized retinal nerve fiber layer defects

Shin

Uhm

Lee

et al. 2013

Eye

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Purpose To evaluate and compare the diagnostic ability of spectral domain optical coherence tomography (SD-OCT) for detecting localized retinal nerve fiber layer (RNFL) defects in topographic RNFL maps and circumpapillary RNFL (cpRNFL) thickness measurements. Methods Sixty-four eyes with localized RNFL defects in red-free RNFL photographs and 72 healthy eyes were included. All participants were imaged with SD-OCT. The area and angular width of the localized RNFL defects were measured with ImageJ software on RNFL thickness map, significance map (yellow pixels, o5% level), and red-free RNFL photographs. The sensitivity, specificity, and area under the receiver operating characteristic curves (AUCs) were calculated for cpRNFL thickness, macular inner retina thickness, and RNFL maps (thickness, significance) according to the quantitative measurements and a o5% level of classification to distinguish eyes with localized RNFL defects from healthy eyes. Results RNFL thickness map (sensitivity 96.9-98.4%, specificity 86.1-98.6%, and AUCs 0.915-0.992) and significance map (sensitivity 96.9-98.4%, specificity 88.9-95.8%, and AUCs 0.937-0.983) showed superior performance in detecting localized RNFL defects compared with other parameters (P-value 0.001-0.024) except for 36 sector cpRNFL thickness (sensitivity 92.2%, specificity 87.5%, and AUCs 0.898; P-value 0.080-0.545). The sensitivity for detecting RNFL defects was related to the angular width, area, and depth of the RNFL defects in the cpRNFL (4 sector, 12 sector) and macular inner retinal measurements. RNFL thickness and significance maps showed a constant sensitivity regardless of variations in angular width, area, and depth of the RNFL defects. Conclusion RNFL thickness and significance maps could be used to distinguish eyes with localized RNFL defects from healthy eyes more effectively than cpRNFL thickness and macular inner retina thickness measurements.

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“…Optical coherence tomography, a well-accepted tool for glaucoma diagnosis, enables to objectively measure the ONH, RNFL and macular thickness parameters. [1][2][3][4][5] Spectral domain OCT (SD-OCT) is a recent technique that enables the imaging of ocular structures with higher resolution and faster scan rate compared with the previous version of this technology (Stratus OCT, Carl Zeiss Meditec Inc., Dublin, CA, USA). 6,7 In addition to the changes that occur in ONH and RNFL, another region that has been proposed to manifest changes in glaucoma is the macula, because more than 50% of the ganglion cells in the retina are located at macula and the ganglion cell layer is more than one-cell-layer thick at the macula.…”

Section: Introductionmentioning

confidence: 99%

Retinal nerve fiber layer and macular inner retina measurements by spectral domain optical coherence tomograph in Indian eyes with early glaucoma

Rao

Jonnadula

Addepalli

et al. 2011

Eye

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Purpose To compare the diagnostic abilities of peripapillary retinal nerve fiber layer (RNFL) and macular inner retina (MIR) measurements by spectral domain optical coherence tomography (SD-OCT) in Indian eyes early glaucoma. Methods In an observational, cross-sectional study, 125 eyes of 64 normal subjects and 91 eyes of 59 early glaucoma patients underwent RNFL and MIR imaging with SD-OCT. Glaucomatous eyes had characteristic optic nerve and RNFL abnormalities and correlating visual field defects and a mean deviation of better than or equal to -6 dB on standard automated perimetry. Areas under the receiver operating characteristic curves (AUC), sensitivities at a fixed specificity and likelihood ratios (LRs) were estimated for all RNFL and MIR parameters. Results The AUCs for the RNFL parameters ranged from 0.537 for the temporal quadrant thickness to 0.821 for the inferior quadrant RNFL thickness. AUCs for the MIR parameters ranged from 0.603 for the superior minus inferior MIR thickness average to 0.908 for ganglion cell complex focal loss volume (GCC-FLV). AUC for the best MIR parameter (GCC-FLV) was significantly better (Po0.001) than that of the best RNFL parameter (inferior quadrant thickness). The sensitivities of these parameters at high specificity of 95%, however, were comparable (52.7% vs 58.2%). Evaluation of the LRs showed that outside normal limits results of most of the RNFL and MIR parameters were associated with large effects on the post-test probability of disease. Conclusion MIR parameters with RTVue SD-OCT were as good as the RNFL parameters to detect early glaucoma.

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Diagnostic Capability of Optical Coherence Tomography (Stratus OCT 3) in Early Glaucoma

Cited by 104 publications

References 22 publications

Relationship between GDx VCC and Stratus OCT in juvenile glaucoma

Relationship between GDx VCC and Stratus OCT in juvenile glaucoma

Diagnostic ability of retinal nerve fiber layer maps to detect localized retinal nerve fiber layer defects

Retinal nerve fiber layer and macular inner retina measurements by spectral domain optical coherence tomograph in Indian eyes with early glaucoma

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