Diagnostic Assays for Crimean-Congo Hemorrhagic Fever

Vanhomwegen, Jessica; Alves, Maria João; Avšič-Županc, Tatjana; Bino, Silvia; Chinikar, Sadegh; Karlberg, Helen; Korukluoğlu, Gülay; Korva, Miša; Mardani, Masoud; Mirazimi, Alì; Mousavi, Mehrdad; Papa, Anna; Saksida, Ana; Sharifi-Mood, Batool; Sidira, Persofoni; Tsergouli, Katerina; Wölfel, Roman; Zeller, H.; Dubois, Philippe

doi:10.3201/eid1812.120710

Cited by 70 publications

(68 citation statements)

References 29 publications

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“…All tests had very high specificity, ranging from 95.5 to 100%. In the same study, IgM and IgG serology sensitivities were found to be 88% and 80% for ELISA and 93.9% and 86.1% for IFA, respectively [80] .…”

Section: Diagnosismentioning

confidence: 75%

Crimean-Congo Hemorrhagic Fever

Kazancıoğlu¹,

Akıncı²,

Bodur³

2018

mjima

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Section: Diagnosismentioning

confidence: 75%

Crimean-Congo Hemorrhagic Fever

Kazancıoğlu¹,

Akıncı²,

Bodur³

2018

mjima

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“…Many reports have been shown that contact with infected animal tissue and blood have transmitted the virus to humans. Also, consumption of uncooked meat can also transmit the infection to humans (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15). Five years ago, we reported 4 patients with CrimeanCongo hemorrhagic fever, who acquired the illness following consumption of uncooked sheep liver (2).…”

Section: U N C O R R E C T E D P R O O Fmentioning

confidence: 99%

“…Death mainly occurs in the second week of disease and in patients who have survived, improvement begins about 10 days after the onset of illness (2,3,6). CCHF virus infection can be diagnosed by several different laboratory tests such as enzyme-linked immunosorbent assay (ELISA), serum neutralization (SN), reverse transcriptase polymerase chain reaction (RT-PCR) assay, and by cell culture to isolate the virus (12)(13)(14).Treatment is supportive, but ribavirin (an anti viral drug, both oral and intravenous formulations) has been used to treat CCHF infection with apparent benefit in previous reports (15)(16)(17)(18)(19)(20)(21)(22). Prevention of the virus in animals is difficult because infection in animals is usually not symptomatic.…”

Section: Introductionmentioning

confidence: 99%

Report of a Family with Crimean-Congo Hemorrhagic Fever Following Contact with Frozen Meat: A Case Seires Study

Metanat¹,

Sharifi-Mood²,

Fathollahzadeh³

et al. 2017

Arch Clin Infect Dis

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Introduction: Crimean-Congo hemorrhagic fever (CCHF) is caused by a tick-borne virus in the family of Bunyaviridae. A hard tick, in the genus of Hyalomma, is a reservoir and also a vector for CCHF virus. Infection in humans usually occurs by infected tick bite or through contact with infected animal tissues and blood. CCHF can also transmit from one infected person to another through contact with infectious blood or body fluids. Human-to human transmission is also reported as a nosocomial infection. Case Presentation: Here, we presented 5 patients from a family with Crimean-Congo hemorrhagic fever, who got the illness at the same time when they cut the frozen meat together. Fortunately, all patients referred to hospital soon and received treatment during 24 to 72 hours after the first sign or symptom was presented. Conclusions: Frozen meat can transmit CCHFV to humans, which can be due to high viral load or a virus with high virulence in the infected animal tissues.

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“…KKKA'nın tipik laboratuvar bulguları, trombositopeni, lökopeni, aspartat aminotransferaz (AST), alanin aminotransferaz (ALT), kreatin kinaz (CK) ve laktat dehidrogenaz (LDH) düzeylerinin yükselmesidir (6,7). Hastamızda ilk günkü hemogram, AST, ALT, LDH ve CK değerleri normal sınırlar-daydı.…”

Section: İrdelemeunclassified