Diagnostic approaches in a series of cases with Graves ophthalmopathy

Abstract

Introduction. The definition of severity and activity of Graves' ophthalmopathy (GO) comprises different parameters.The aim of this study is to select the most appropriate severity and activity criteria, respectively scores and to investigate a possible correlation among them.Subjects and methods. The study included 51 patients with GO (43 females, 8 males), mean age 46.8±11.2 years. The patients were evaluated by: clinical exam, laboratory parameters (TSH, FT4, FT3, thyroid autoantibodies) and imagistic means, performed in selected cases (CT or MRI).Results. The GO activity was assessed by the clinical activity score (CAS). We quantified the EUGOGO severity criteria, by allotting points for each selected parameter. According to the recommended criteria, the cases were divided into active (n=26) and inactive forms (n=25). There were no significant statistical differences regarding CAS between euthyroid cases (n=14) and dysthyroid cases (n=37). Serum thyroid receptor antibodies (TRAb) levels did not correlate with CAS or severity scores. Severity scores correlated significantly with CAS (Pearson correlation index 0.546, r2=0.290, p=0.0001).Conclusion. Active forms of GO showed higher severity scores than the inactive ones. The severity scores correlated significantly with CAS scores. Neither CAS, nor severity scores correlated significantly with the severity of thyrotoxicosis.

Surgery for graves' ophthalmopathy: When and what for? The experience of Iasi

“…Other authors (24,25) consider that orbit inflammation refractory to non-surgical approach may also be an indication for orbit surgery in up to 25% of patients. The psychological impact for choosing orbit surgery is, however, very important in all situations (25,26). Orbital decompression decreases intraorbitary pressure rapidly, together with an improvement of venous and lymphatic drainage.…”

Bioinformatic Analysis Identifies Potentially Key Differentially Expressed Genes and Pathways in Orbital Adipose Tissues of Patients with Thyroid Eye Disease

“…Sex difference in its incidence has been noted with female having higher risk than male (6)(7)(8)(9). Clinically, the severity of Graves' disease, genders, radiotherapy and clinical course of thyroid disorder do not influence the consequence of TED (10,11). Due to the severe adverse effects and complication of existing therapies including orbital radiation and surgery as well as immunosuppression, the satisfying treatments for TED remain challenging (12)(13)(14).…”