Diagnostic Applications of Saliva in Dentistry

Prabhakar, A R; Gulati, Akanksha; Mehta, Dhoom Singh; Sugandhan, S

doi:10.5005/jp-journals-10005-1012

Cited by 9 publications

(8 citation statements)

References 15 publications

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“…Therefore, the sequential amino acid in a protein provides a link between the proteins and their respective coding genes through genetic code, and the protein complement of the genome is known as the proteome. [4]…”

Section: Diagnostic Uses Of Saliva In Systemic Diseasesmentioning

confidence: 99%

“…The difficulties encountered in the study of the peptidome (the complete set of peptides encoded by a particular genome or present within a particular cell type) are due to the high genetic polymorphisms, complicated by individual insertions/deletions and alternative splicing to the complex posttranslational maturations including different proteolytic cleavages and glycosylation, phosphorylation and sulfation processes. [4]…”

Section: Diagnostic Uses Of Saliva In Systemic Diseasesmentioning

confidence: 99%

“…In oral cancer, miRNAs have been shown to affect cell proliferation, apoptosis and even chemotherapy resistance in oropharyngeal squamous cell carcinomas (OSCC) patients, miRNAs have also been observed in OSCC to be epigenetically regulated by DNA methylation. [74]…”

Section: Diagnostic Uses Of Saliva In Systemic Diseasesmentioning

confidence: 99%

“…For example, taurine and piperidine are considered as the oral cancer-specific diagnostic marker [Table 3]. [4]…”

Section: Diagnostic Uses Of Saliva In Systemic Diseasesmentioning

confidence: 99%

“…The various chemical components of saliva include water, inorganic compounds (ions), organic compounds (nonproteins and lipids), protein/polypeptides and hormones, and an array of analytes. [4]…”

Section: Introductionmentioning

confidence: 99%

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Salivaomics: The current scenario

Shah

2018

J Oral Maxillofac Pathol

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For generations, blood has been the medium of choice for diagnosing most diseases and conditions. The reason for this is mainly the limitations of technology. The concept of oral diagnostics is preferred to more invasive methods. In recent years, it has become evident that the salivary constituents become detectably altered in response to certain disease states. Even so, what is most impressive is that salivary biomarkers not only arise in correlation with oral disorders but also those of distal tissues and organs. This suggests that oral fluids may represent a substantial reservoir of molecular and microbial information capable of communicating the onset or presence of disease throughout the body. An initiative of the National Institute of Dental and Craniofacial Research created a roadmap to achieve these goals whereby, with the use of oral fluids as the diagnostic medium, it would become possible to scrutinize the health and/or disease status of patients. The real promise of salivary analysis use is the ability of the patient or clinician to directly and continuously assess disease status, progression and therapeutic efficacy. The sensitive analysis may even allow presymptomatic diagnosis. There are five major diagnostic alphabets available in saliva namely, proteins, messenger RNAs, micro-RNAs (mi-RNAs), metabolic compounds and microbes which offer substantial advantages for salivary diagnostics because, the state of the disease may be associated with detectable changes in one, but not all, dimensions. Recently, the Salivaomics Knowledge Base (SKB) has been established by aligning the salivary biomarker discovery. The SKB constitutes data repository, management system and web resource fabricated to support human salivary proteomics, transcriptomics, miRNA, metabolomics and microbiome research.

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Section: Diagnostic Uses Of Saliva In Systemic Diseasesmentioning

confidence: 99%

Section: Diagnostic Uses Of Saliva In Systemic Diseasesmentioning

confidence: 99%

Section: Diagnostic Uses Of Saliva In Systemic Diseasesmentioning

confidence: 99%

“…For example, taurine and piperidine are considered as the oral cancer-specific diagnostic marker [Table 3]. [4]…”

Section: Diagnostic Uses Of Saliva In Systemic Diseasesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%