Diagnostic and therapeutic standardization still lacking in parotid lymphoma: elucidating the evidence gaps in a rare entity

Lavalle, Salvatore; Lechien, Jerome Rene; Chiesa-Estomba, Carlos; Cocuzza, Salvatore; Maniaci, Antonino

doi:10.1007/s00405-023-08419-6

Cited by 1 publication

(1 citation statement)

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“…In our series, we did not consider a preoperative histological or cytological assessment necessary in 28% of patients with a clear clinical correlation between the parotid swelling and the resection of the primary (in 13 cases the first treatment was performed elsewhere and in 1 case in our center). As for parotid lymphoma [ 36 ], a standardized diagnostic work-up is still lacking for secondary parotid lesions, with ultrasound representing an emerging diagnostic tool. Recently, the administration of gas contrast medium has enhanced the accuracy of ultrasound in differentiating between benign and malignant lesions [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Surgical Management of Patients with Parotid Involvement from Non-Melanoma Skin Cancer of the Head and Neck

Carta,

Corrias,

Tatti

et al. 2024

JPM

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We conducted a retrospective, longitudinal study on a single-center series of patients who underwent parotidectomy in the management of advanced head and neck non-melanoma skin cancer (hnNMSC). The aim of this study was to identify prognostic factors associated with worse outcomes. Forty-one men and nine women were included. The mean age at the time of surgery was 78.9 years. The 5-year overall survival, disease-specific survival, locoregional recurrence-free survival, and distant metastasis-free survival calculated with Kaplan–Meier curves were 39.9%, 56.3%, 58.6%, and 82.1%, respectively. A univariate analysis showed that the status of the margins, facial nerve direct involvement, lymph vascular invasion, and histological grading were associated with worse outcomes (p < 0.05). Positive margins were associated with worse disease-specific survival also in a multivariate analysis (p = 0.001, HR = 32.02, and CIs 4.338 to 351.3). Because the resection in free margins is the most important prognostic factor, early diagnosis or, in the case of advanced disease, extensive surgical resection with concomitant reconstruction is needed. Adjuvant therapy is indicated in selected cases.

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Section: Discussionmentioning

confidence: 99%