Diagnostic and prognostic values of integrin α subfamily mRNA expression in colon adenocarcinoma

Gong, Yizhen; Ruan, Guo‐Tian; Liao, Xiwen; Wang, Xiang‐Kun; Liao, Cun; Wang, Shuai; Gao, Feng

doi:10.3892/or.2019.7216

Cited by 13 publications

(18 citation statements)

References 69 publications

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“…The association of ITGα1β1 and the progression of CRC has been reported 24 . The ITGα8 mRNA was reported as a potential diagnostic biomarker whereas ITGα5 may serve as an independent prognosis indicator for CRC 25 . In the CRC cells described herein, the predominant expressions were ITGα5‐subunit in HCT‐116 and ITGβ4‐subunit in HT‐29 cells.…”

Section: Discussionmentioning

confidence: 57%

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Periostin regulates autophagy through integrin α5β1 or α6β4 and an AKT‐dependent pathway in colorectal cancer cell migration

Thongchot

Singsuksawat

Sumransub

et al. 2020

J Cellular Molecular Medi

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Colorectal cancer (CRC) is the most common gastrointestinal malignancy worldwide with a remarkably high mortality rate. 1 It is the second leading cause of cancer death and over 50,000 deaths annually are estimated in the United States. 2 The prognosis of CRC is clearly related to the level of the tumour penetration through the bowel wall and the presence or absence of nodal invasion. 3 The mechanism of how CRC cells can migrate and metastasize is an active field of study. Periostin (PN) is a secreted extracellular matrix protein mainly produced by mesenchymal fibroblasts in osteoblasts, periosteum,

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Section: Discussionmentioning

confidence: 57%

“…24 The ITGα8 mRNA was reported as a potential diagnostic biomarker whereas ITGα5 may serve as an independent prognosis indicator for CRC. 25 In the CRC cells described herein, the predominant expressions were ITGα5-subunit in HCT-116 and and α6β4. 5,19 In the present study,…”

Section: Discussionmentioning

confidence: 76%

Periostin regulates autophagy through integrin α5β1 or α6β4 and an AKT‐dependent pathway in colorectal cancer cell migration

Thongchot

Singsuksawat

Sumransub

et al. 2020

J Cellular Molecular Medi

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“…For example, in colon adenocarcinoma (CAC), COL1A2 , THBS2 , and COL1A1 were related to prognosis [ 20 ]. In addition, it was found that the level of ITGA5 in CAC was significantly linked to overall survival (OS), which might serve as an independent prognostic indicator [ 21 ]. In neuroblastoma, it has been revealed that there existed an association between SDC3 expression and improved prognosis [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Progressive and Prognostic Performance of an Extracellular Matrix-Receptor Interaction Signature in Gastric Cancer

et al. 2020

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The role of an extracellular matrix- (ECM-) receptor interaction signature has not been fully clarified in gastric cancer. This study performed comprehensive analyses on the differentially expressed ECM-related genes, clinicopathologic features, and prognostic application in gastric cancer. The differentially expressed genes between tumorous and matched normal tissues in The Cancer Genome Atlas (TCGA) and validation cohorts were identified by a paired t -test. Consensus clusters were built to find the correlation between clinicopathologic features and subclusters. Then, the least absolute shrinkage and selection operator (lasso) method was used to construct a risk score model. Correlation analyses were made to reveal the relation between risk score-stratified subgroups and clinicopathologic features or significant signatures. In TCGA (26 pairs) and validation cohort (134 pairs), 25 ECM-related genes were significantly highly expressed and 11 genes were downexpressed in gastric cancer. ECM-based subclusters were slightly related to clinicopathologic features. We constructed a risk score model = 0.081 ∗ log 2 CD 36 + 0.043 ∗ log 2 COL 5 A 2 + 0.001 ∗ log 2 ITGB 5 + 0.039 ∗ log 2 SDC 2 + 0.135 ∗ log 2 SV 2 B + 0.012 ∗ log 2 THBS 1 + 0.068 ∗ log 2 VTN + 0.023 ∗ log 2 VWF . The risk score model could well predict the outcome of patients with gastric cancer in both training ( n = 351 , HR: 1.807, 95% CI: 1.292-2.528, P = 0.00046 ) and validation ( n = 300 , HR: 1.866, 95% CI: 1.347-2.584, P = 0.00014 ) cohorts. Besides, risk score-based subgroups were associated with angiogenesis, cell adhesion molecules, complement and coagulation cascades, TGF-beta signaling, and mismatch repair-relevant signatures ( P < 0.0001 ). By univariate (1.845, 95% CI: 1.382-2.462, P < 0.001 ) and multivariate (1.756, 95% CI: 1.284-2.402, P < 0.001 ) analyses, we regarded the risk score as an independent risk factor in gastric cancer. Our findings revealed that ECM compositions became accomplices in the tumorigenesis, progression, and poor survival of gastric cancer.

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“…A study found that ITGA8 is highly expressed in early recurring myeloma and can be used as a potential marker of multiple myeloma recurrence [ 34 ]. It is also highly expressed in colon cancer tissues [ 35 ]. ITGA8 can also be used to predict the prognosis of clear cell renal cell carcinoma [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Expression and Prognostic Analysis of Integrins in Gastric Cancer

Wang

Zhang

et al. 2020

Journal of Oncology

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Background. Integrins are involved in the biological process of a variety of cancers, but their importance in the diagnosis and prognosis of gastric cancer (GC) is still unclear. Therefore, this study aimed at exploring the significance of ITG gene expression in GC to evaluate its diagnosis and prognosis. Methods. GEPIA data were used to evaluate the mRNA expression of ITG genes in GC patients. The prognostic value of these genes was assessed by analyzing their mRNA expression using the Kaplan–Meier curve. The biological function of ITG genes was evaluated by GC tissue sequencing combined with GSEA bioinformatics. Based on the sequencing data, ITGA5 with the largest expression difference was selected for verification, and RT-PCR was used to verify its mRNA expression level in 40 pairs of GC and normal tissues. Results. ITG (A2, A3, A4, A5, A6, A11, AE, AL, AM, AV, AX, B1, B2, B4, B5, B6, and B8) was highly expressed in GC tissues, while ITGA8 was low, compared with their expression in normal tissues. RNA-seq data shows that ITG (A2, A5, A11, AV, and B1) expression was associated with poor prognosis and overall survival. In addition, combined with the results of GC tissue mRNA sequencing, it was further found that the differentially expressed genes in the ITGs genes. ITGA5 was highly expressed in GC tissues compared with its expression in normal tissues, as evaluated by qRT–PCR ( P < 0.001 ) and ROC ( P < 0.001 , AUC (95% CI) = 0.747 (0.641–0.851)), and confirmed that ITGA5 expression was a potential diagnostic marker for GC. Bioinformatics analysis revealed that the signaling pathway involved in ITGA5 was mainly enriched in focal adhesion, ECM-receptor interaction, and PI3K-AKT and was mainly involved in biological processes such as cell adhesion, extracellular matrix, and cell migration. Conclusion. This study suggested that ITGs were associated with the diagnosis and prognosis of GC and discovered the prognostic value and biological role of ITGA5 in GC. Thus, ITGA5 might be used as a potential diagnostic marker for GC.

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Diagnostic and prognostic values of integrin α subfamily mRNA expression in colon adenocarcinoma

Cited by 13 publications

References 69 publications

Periostin regulates autophagy through integrin α5β1 or α6β4 and an AKT‐dependent pathway in colorectal cancer cell migration

Periostin regulates autophagy through integrin α5β1 or α6β4 and an AKT‐dependent pathway in colorectal cancer cell migration

Progressive and Prognostic Performance of an Extracellular Matrix-Receptor Interaction Signature in Gastric Cancer

Expression and Prognostic Analysis of Integrins in Gastric Cancer

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