Diagnostic and prognostic value of galectin-3, serum creatinine, and cystatin C in chronic kidney diseases

Ji, Fen; Zhang, Shuqin; Jiang, Xia; Xu, Yaolin; Chen, Zhiwei; Fan, Yanbo; Wang, Wenjuan

doi:10.1002/jcla.22074

Cited by 17 publications

(19 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gal-3 is a well-established biomarker for cardiac fibrosis, ventricular dysfunction, and poor prognosis in heart failure [ 21 – 23 ]. In addition, Gal-3 has demonstrated diagnostic and prognostic value in diseases of the kidney [ 9 , 11 , 18 ]. Drechsler et al found a positive association between elevated levels of Gal-3 and adverse outcomes in patients with preexisting renal disease.…”

Section: Discussionmentioning

confidence: 99%

“…In animal models, Gal-3 is acutely up-regulated in the kidneys in response to ischemic and toxic injury and is associated with renal fibrosis [ 14 – 17 ]. In humans, elevated levels of circulating Gal-3 have been found to be associated with increased risk of incident chronic kidney disease (CKD) and loss of kidney function over time [ 11 , 18 ]. Gal-3 therefore can be considered a marker of both acute and chronic inflammatory processes in the kidneys, even in the absence of traditional clinical markers of renal injury.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Elevated preoperative Galectin-3 is associated with acute kidney injury after cardiac surgery

et al. 2018

View full text Add to dashboard Cite

BackgroundPrevious research suggests that novel biomarkers may be used to identify patients at increased risk of acute kidney injury following cardiac surgery. The purpose of this study was to evaluate the relationship between preoperative levels of circulating Galectin-3 (Gal-3) and acute kidney injury after cardiac surgery.MethodsPreoperative serum Gal-3 was measured in 1498 patients who underwent coronary artery bypass graft (CABG) surgery and/or valve surgery as part of the Northern New England Biomarker Study between 2004 and 2007. Preoperative Gal-3 levels were measured using multiplex assays and grouped into terciles. Univariate and multinomial logistic regression was used to assess the predictive ability of Gal-3 terciles and AKI occurrence and severity.ResultsBefore adjustment, patients in the highest tercile of Gal-3 had a 2.86-greater odds of developing postoperative KDIGO Stage 2 or 3 (p < 0.001) and 1.70-greater odds of developing KDIGO Stage 1 (p = < 0.001), compared to the first tercile. After adjustment, patients in the highest tercile had 2.95-greater odds of developing KDIGO Stage 2 or 3 (p < 0.001) and 1.71-increased odds of developing KDIGO Stage 1 (p = 0.001), compared to the first tercile. Compared to the base model, the addition of Gal-3 terciles improved discriminatory power compared to without Gal-3 terciles (test of equality = 0.042).ConclusionElevated preoperative Gal-3 levels significantly improves predictive ability over existing clinical models for postoperative AKI and may be used to augment risk information for patients at the highest risk of developing AKI and AKI severity after cardiac surgery.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Elevated preoperative Galectin-3 is associated with acute kidney injury after cardiac surgery

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Current practices utilize two categories of biomarkers for CKD, those that estimate GFR and those that indicate damage to a specific renal function (albuminuria). Similarly, the search for new biomarkers has two directions, indicators of GFR which are routinely assayed in the serum[ 211 - 219 ] and indicators of specific types of kidney injury which are assayed in the urine or serum[ 220 - 227 ].…”

Section: Future Developmentsmentioning

confidence: 99%

Establishing the presence or absence of chronic kidney disease: Uses and limitations of formulas estimating the glomerular filtration rate

Alaini

Malhotra

Rondon‐Berrios

et al. 2017

WJM

View full text Add to dashboard Cite

The development of formulas estimating glomerular filtration rate (eGFR) from serum creatinine and cystatin C and accounting for certain variables affecting the production rate of these biomarkers, including ethnicity, gender and age, has led to the current scheme of diagnosing and staging chronic kidney disease (CKD), which is based on eGFR values and albuminuria. This scheme has been applied extensively in various populations and has led to the current estimates of prevalence of CKD. In addition, this scheme is applied in clinical studies evaluating the risks of CKD and the efficacy of various interventions directed towards improving its course. Disagreements between creatinine-based and cystatin-based eGFR values and between eGFR values and measured GFR have been reported in various cohorts. These disagreements are the consequence of variations in the rate of production and in factors, other than GFR, affecting the rate of removal of creatinine and cystatin C. The disagreements create limitations for all eGFR formulas developed so far. The main limitations are low sensitivity in detecting early CKD in several subjects, e.g., those with hyperfiltration, and poor prediction of the course of CKD. Research efforts in CKD are currently directed towards identification of biomarkers that are better indices of GFR than the current biomarkers and, particularly, biomarkers of early renal tissue injury.

show abstract

“…Galectin‐3 is an α‐galactoside‐binding lectin that has been shown to mediate cell‐to‐cell and cell‐to‐extracellular matrix interactions and act as a novel chemoattractant for monocytes and macrophages . Studies have supported an association between serum galectin‐3 levels and atrial fibrosis demonstrated with delayed‐ enhancement magnetic resonance imaging in AF patients …”

Section: Introductionmentioning

confidence: 99%

“…9 Galectin-3 is an α-galactoside-binding lectin that has been shown to mediate cell-to-cell and cell-to-extracellular matrix interactions and act as a novel chemoattractant for monocytes and macrophages. 10,11 Studies have supported an association between serum galectin-3 levels and atrial fibrosis demonstrated with delayed-enhancement magnetic resonance imaging in AF patients. 12,13 In this study, we aimed to investigate the relation between serum galectin-3 levels and echocardiographic markers of thromboembolism, including LAAFV, LA/LAA-located SEC and thrombus.…”

mentioning

confidence: 95%

Serum galectin‐3 level as a marker of thrombogenicity in atrial fibrillation

Koçyiğit

Gürses²,

Yalçın

et al. 2017

Clinical Laboratory Analysis

View full text Add to dashboard Cite

show abstract

Diagnostic and prognostic value of galectin-3, serum creatinine, and cystatin C in chronic kidney diseases

Abstract: Our study verified Gal-3, CysC and SCr were negatively related to eGFR. Besides, it is suggested that Gal-3 can be used as an indicating factor in the diagnosis of CKD; the joint analysis of Gal-3, CysC and SCr for CKD may distinctly improve diagnostic accuracy.

Cited by 17 publications

References 32 publications

Elevated preoperative Galectin-3 is associated with acute kidney injury after cardiac surgery

Elevated preoperative Galectin-3 is associated with acute kidney injury after cardiac surgery

Establishing the presence or absence of chronic kidney disease: Uses and limitations of formulas estimating the glomerular filtration rate

Serum galectin‐3 level as a marker of thrombogenicity in atrial fibrillation

Contact Info

Product

Resources

About