Diagnostic and Prognostic Value of IL-6 and sTREM-1 in SIRS and Sepsis in Children

Smok, Beata; Domagalski, Krzysztof; Pawłowska, Małgorzata

doi:10.1155/2020/8201585

Cited by 22 publications

(24 citation statements)

References 40 publications

(46 reference statements)

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“…Notably, the percentage of Tregs also significantly increased in severe neutropenic septic patients, which partly explained the reason for the increase of IL-10. Diepold et al thought that IL-6 performed well in predicting severity of bacterial infection and sepsis, with high sensitivity and specificity (90% and 85%), which is consistent with the research of Smok et al (32,33). We also observed that the IL-6 and IL-10 levels were significantly different between the survival group and the death group, suggesting that high levels of IL-6 and IL-10 are associated with poor prognosis.…”

Section: Discussionsupporting

confidence: 91%

The clinical outcomes and biomarker features of severe sepsis/ septic shock with severe neutropenia: a retrospective cohort study

Yin

Wang

et al. 2021

Transl Pediatr

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Background: Severe sepsis/septic shock with severe neutropenia often leads to poor prognosis. However, it is unknown if severe neutropenia is associated with different clinical outcomes and biomarker features in severe sepsis/septic patients. Methods: This retrospective cohort study enrolled 141 severe sepsis/septic shock patients admitted to intensive care unit of Shanghai Children's Medical Center between January 2015 and November 2019. Patients were followed up for the development of ventilation support, the use of vasoactive drugs, continuous renal replacement therapy (CRRT) procedure, and mortality. Biomarkers that reflect the level of inflammation in severe sepsis/septic shock patients with neutropenia were compared to that in patients without neutropenia. Results: Of 141 patients enrolled, 54 patients suffered from severe sepsis/septic shock with severe neutropenia. In patients with severe sepsis/septic shock, severe neutropenia as a complication was an independent risk factor for the use of vasoactive drugs (RR 9.

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Section: Discussionsupporting

confidence: 91%

The clinical outcomes and biomarker features of severe sepsis/ septic shock with severe neutropenia: a retrospective cohort study

Yin

Wang

et al. 2021

Transl Pediatr

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“…Several biomarkers (IL-6, S100, NSE, and 5HIAA) were studied in our research, and only one of them (IL-6) demonstrated potential diagnostic significance for the prognosis of post-neurosurgical meningitis. Serum IL-6 is used as a diagnostic and prognostic biomarker for inflammation, autoimmune disorders, cancer [ 8 , 23 ], cardiovascular diseases [ 24 ], and infection [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

4-Hydroxyphenyllactic Acid in Cerebrospinal Fluid as a Possible Marker of Post-Neurosurgical Meningitis: Retrospective Study

Pautova

Meglei

Chernevskaya

et al. 2022

JPM

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The search for new potential biomarkers for the diagnostics of post-neurosurgical bacterial meningitis is required because of the difficulties in its early verification using results of the routine laboratory and biochemical analyses of the cerebrospinal fluid (CSF). The goal of the study was to determine the contents of the aromatic metabolites and biomarkers in the CSF samples of the post-neurosurgical patients (n = 82) and their potential diagnostical significance for the evaluation of the risk of post-neurosurgical meningitis. Patients with signs of post-neurosurgical meningitis (n = 30) had lower median values of glucose and higher values of cell count, neutrophils, lactate, protein, 3-(4-hydroxyphenyl)lactic acid (p-HPhLA), and interleukin-6 (IL-6) than patients without signs of post-neurosurgical meningitis (n = 52). ROC analysis for IL-6 and p-HPhLA resulted in 0.785 and 0.734 values of the area under the ROC curve, with sensitivity 96.30 and 66.67%; specificity 54.17 and 82.69%, respectively. IL-6 should be considered as a non-specific biomarker, in contrast to the microbial metabolite p-HPhLA. If the concentration of p-HPhLA was more or equal to 0.9 µmol/L, the risk of bacterial complications was 9.6 times higher. p-HPhLA is a promising marker for the prognosis of post-neurosurgical meningitis, and its determination on a larger group of post-neurosurgical patients can subsequently prove its diagnostic significance for the verification of CNS infections.

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“…Материалы и методы. В проспективное, рандомизированное исследование включили 40 детей, медианный возраст которых составил 14 [12][13][14][15][16][17][18][19][20][21][22]5] месяцев, вес -8,8 [7, кг. Всем пациентам проводили радикальную коррекцию септальных ВПС в условиях ИК.…”

Section: резюмеunclassified

“…Исследование провели на базе отделения анестезиологии и реанимации ФГБНУ НИИ КПССЗ. Обследовали 40 детей в возрасте от 6 до 36 месяцев, средний возраст составил 14 [12][13][14][15][16][17][18][19][20][21][22]5] месяцев, вес -8,8 [7,[5][6][7][8][9][10][11] кг, которым выполнили плановую радикальную коррекцию дефекта межжелудочковой или межпредсердной перегородки в условиях ИК. Анализ мощности исследования проводили по формуле: n=(t 2 *P*Q)/ 2 , где t -критическое значение критерия Стьюдента при соответствующем уровне значимости; в данном исследовании -0,05; -предельно допустимая ошибка (%); P -доля случаев, в которых встречали изучаемый признак (%); Q -доля случаев, в которых не встречали изучаемый признак (100-P).…”

Section: материал и методыunclassified

The Eﬀect of Erythrocyte-Containing Donor Blood Components in the Priming of the Cardiopulmonary Bypass Circuit on the Development of Systemic Inﬂammation During Correction of Congenital Heart Defects in Children

Борисенко

Ивкин

Шукевич

et al. 2022

Obŝaâ reanimatologiâ

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Various pathological factors accompanying any cardiac surgery can cause intraoperative systemic inﬂammatory responses (SIR). As the number of cardiac surgical interventions grows worldwide, the issue of SIR prevention appears highly relevant.Aim of the study. To determine the eﬀect of not using donor blood components in the priming of the cardiopulmonary bypass circuit in children with septal congenital heart defects, operated under cardiopulmonary bypass, on the severity of SIR.Material and methods. A prospective, randomized study included 40 children with a median age of 14 [12–22.5] months and weight of 8.8 [7.25–11] kg. All patients underwent radical correction of septal defect under cardiopulmonary bypass. The patients were divided into two groups depending on the use of donor blood components for priming the CPB. The severity of SIR was assessed using four speciﬁc serum biomarkers such as interleukin 1b (IL-1b), interleukin 6 (IL-6), interleukin 10 (IL-10), and tumor necrosis factor alpha (TNF-α), measured before the operation, after the CPB and 16 hours after the surgery. In addition, the intra- and postoperative periods were evaluated.Results. The safety of the proposed strategy of skipping the donor blood was confirmed by lack of any organ dysfunction in all patients, as well as a significant difference in the balance of oxygen delivery and consumption. In addition, the levels of systemic inflammation markers after CPB were significantly higher in patients who had transfusion: IL-1b was 3.3 [3.2–3.48] pg/mL vs 2.86 [2.7–3.11] pg/mL (P=0.003) and TNF-α reached 1.81 [1.37–3.3] pg/mL vs 1.33 [1.26–1.76] pg/mL (P=0.034). Meanwhile, 16 hours post surgery, IL-6 and IL-10 levels were significantly higher in the group using donor blood components with IL-6 being 48.91 [33.89–57.6] pg/mL vs 31.56 [26.83–48.89] pg/mL (P=0.087) and IL-10 reaching 0.8 [0.76–1.43] pg/mL vs 0.69 [0.6–0.83] pg/mL (P=0.005).Conclusion. The study demonstrates and conﬁrms the safety and eﬃcacy of cardiopulmonary bypass without using donor blood components to reduce the severity of the systemic inﬂammatory response in children undergoing correction of septal congenital heart defects.

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Diagnostic and Prognostic Value of IL-6 and sTREM-1 in SIRS and Sepsis in Children

Cited by 22 publications

References 40 publications

The clinical outcomes and biomarker features of severe sepsis/ septic shock with severe neutropenia: a retrospective cohort study

The clinical outcomes and biomarker features of severe sepsis/ septic shock with severe neutropenia: a retrospective cohort study

4-Hydroxyphenyllactic Acid in Cerebrospinal Fluid as a Possible Marker of Post-Neurosurgical Meningitis: Retrospective Study

The Eﬀect of Erythrocyte-Containing Donor Blood Components in the Priming of the Cardiopulmonary Bypass Circuit on the Development of Systemic Inﬂammation During Correction of Congenital Heart Defects in Children

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