Diagnostic and prognostic value of serum procalcitonin concentrations in primary lung cancers

Patout, Maxime; Salaün, Mathieu; Brunel, V.; Bota, Suzanna; Cauliez, Bruno; Thiberville, Luc

doi:10.1016/j.clinbiochem.2014.09.002

Cited by 51 publications

(49 citation statements)

References 18 publications

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“…PCT levels may also be elevated in medullary thyroid carcinoma [26] and small-cell lung carcinoma [27], paralytic/vascular ileus exhibiting paraneoplastic production [28] and renal failure [29]. PCT, although useful in bacterial sepsis, has no value in the assessment of fungal or viral infections and shows no response to intracellular microorganisms (i.e.…”

Section: Review Series: Immunology Of Pregnancymentioning

confidence: 99%

Overview of procalcitonin in pregnancy and in pre-eclampsia

Mangogna

Agostinis

Ricci

et al. 2019

Clinical and Experimental Immunology

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Procalcitonin (PCT), a precursor for calcitonin, is a prohormone involved in the inflammatory processes, which has been poorly studied in the context of pregnancy. During severe inflammation, PCT derives from almost all cell types, including monocytes and parenchymal tissues, making it a good predictive and diagnostic marker of an inflammatory state with rapidly increased serum levels in inflammation or sepsis. In normal pregnancy, PCT is basally expressed at very low level by decidual cells, even if decidual macrophages, which in normal pregnancy are skewed to M2 macrophages, are resistant to lipopolysaccharide (LPS)-induced production of PCT. As PCT increase is associated with an inflammatory state, several research groups investigated whether PCT can be considered a marker of pre-eclampsia, a pregnancy disease characterized by systemic inflammation. The first aim of this review is to summarize what is already known about the tissues synthesizing PCT, about the stimuli that cause the increase of circulating PCT levels and how PCT acts as a proinflammatory stimulus by itself. Secondly, we will describe the role of this prohormone in normal pregnancy and in pregnancies complicated by pre-eclampsia, highlighting the involvement of the decidual macrophages and the proinflammatory cytokine tumor necrosis factor-α in the modulation of PCT expression in the decidual microenvironment.

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Section: Review Series: Immunology Of Pregnancymentioning

confidence: 99%

Overview of procalcitonin in pregnancy and in pre-eclampsia

Mangogna

Agostinis

Ricci

et al. 2019

Clinical and Experimental Immunology

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show abstract

“…The clinical interpretation of elevated PCT concentration in blood represents a great challenge in cancer patients since its values might be influenced by several factors such as the presence of metastasis or neuroendocrine function of malignant tissue (eg, small-cell lung cancer). In these cases, PCT concentrations can be elevated regardless of infections, manifesting a poor specificity for bacterial infection (Patout et al, 2014).…”

mentioning

confidence: 99%

Correlation of Glasgow Prognostic Score or Procalcitonin to Clinical Variables in Patients with Pretreatment Lung Cancer

Kim¹,

Seok²,

Hyun³

et al. 2016

BSL

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Unfortunately, the five-year survival rate of lung cancer is relatively low compared with other cancers. Therefore, better predictors are need for prognosis, therapeutic strategy, risk stratification and predicting long-term mortality of lung cancer. Recently, increasing data suggest that Glasgow Prognostic Score (GPS) and procalcitonin levels are useful predictor cancer prognosis. In this study, we retrospectively investigated the correlation of GPS or procalcitonin to clinical variables in patients with pretreatment lung cancer. In 135 patients with pretreatment lung cancer, GPS, procalcitonin, demographic characteristics, hematological, coagulation, biochemical, inflammatory and cardiac markers were measured. Monocyte, eosinophil, basophil, neutrophil to lymphocyte ratio, red cell distribution width (RDW), platelet to lymphocyte ratio, mean platelet volume to platecrit ratio, D-dimer and prothrombin time (PT) levels were higher, whereas mean platelet volume was lower than their normal ranges. Glucose and sodium levels were low, whereas gamma glutamyl transferase (GGT), total bilirubin, creatinine and inorganic phosphorus concentrations were increase compared their normal ranges. Procalcitonin, high sensitivity C-reactive protein and troponin-I concentrations were elevated compared with their normal ranges. GPS had significantly positive or negative relations to cancer stage, hematological, coagulation, biochemical, inflammatory and troponin-I. Based on the data, we suggest that GPS may be a potent and useful predictor for prognosis, therapeutic strategy, risk stratification and predicting long-term mortality of lung cancer.

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“…Similar results were found in the study of Patout, et al Procalcitonin levels are higher in lung cancer patients with neuroendocrine component and in patients with metastatic disease. In this study, high procalcitonin level was found to be a negative prognostic factor [5].…”

Section: Discussionmentioning

confidence: 50%

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2024

HIJ

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Diagnostic and prognostic value of serum procalcitonin concentrations in primary lung cancers

Cited by 51 publications

References 18 publications

Overview of procalcitonin in pregnancy and in pre-eclampsia

Overview of procalcitonin in pregnancy and in pre-eclampsia

Correlation of Glasgow Prognostic Score or Procalcitonin to Clinical Variables in Patients with Pretreatment Lung Cancer

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