Diagnostic and prognostic significance of CA IX and suPAR in gastric cancer

Fidan, Evren; Menteşe, Ahmet; Özdemir, Feyyaz; Kavgacı, Halil; Karahan, Süleyman Caner; Aydin, Faruk

doi:10.1007/s12032-013-0540-9

Cited by 42 publications

(40 citation statements)

References 14 publications

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“…In vitro studies have shown that suPAR is associated with cell adhesion, migration, and proliferation [19,20]. Elevated suPAR levels have been determined in solid cancers such as ovarian [21], endometrial, cervical [22], breast [23], stomach [24], colon [25], and non-small cell lung cancer [26]. Positive associations between serum suPAR levels and soluble serum CD138, creatinine, β2 microglobulin, stage of disease, and extramedullary bone marrow involvement have been reported in patients with multiple myeloma [27].…”

Section: Discussionmentioning

confidence: 99%

The Prognostic Significance of Soluble Urokinase Plasminogen Activator Receptor in Acute Myeloid Leukemia

Erkut¹,

Menteşe²,

Özbaş³

et al. 2016

Tjh

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Objective:The soluble urokinase plasminogen activator receptor (suPAR) is a soluble form of the urokinase plasminogen activator receptor expressed in various immune and cancer cells. The levels of suPAR have been demonstrated to correlate with prognosis in various cancers. This study was intended to investigate serum suPAR levels and their effect on prognosis in patients with acute myeloid leukemia (AML).Materials and Methods:Thirty newly diagnosed patients with AML and 29 healthy individuals were enrolled. Serum suPAR levels were analyzed by enzyme-linked immunosorbent assay.Results:Serum suPAR levels were significantly higher in patients with AML than in healthy individuals (9±5.9 ng/mL and 2.4±1.4 ng/mL, respectively; p<0.001). Positive correlation was determined between suPAR levels and white blood cell counts (p<0.01). Serum suPAR levels were lower in patients who achieved complete response than in patients not achieving complete response (5.5±2.2 ng/mL and 12±6.6 ng/mL, respectively; p<0.001). The median overall survival was longer in patients with serum suPAR levels below 6.71 ng/mL than in those with serum suPAR levels above 6.71 ng/mL (12.6±13.2 months and 1.71±0.6 months, respectively; p=0.02). Multivariate Cox regression analysis showed that suPAR had independent prognostic value (95% confidence interval: 1.029-6.259; p<0.05) in AML.Conclusion:Serum suPAR levels can be used as a prognostic marker in AML.

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Section: Discussionmentioning

confidence: 99%

The Prognostic Significance of Soluble Urokinase Plasminogen Activator Receptor in Acute Myeloid Leukemia

Erkut¹,

Menteşe²,

Özbaş³

et al. 2016

Tjh

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“…Notably, eosinophilia in the asthmatic lung is not sufficient to induce eosinophil CAR4 expression because overexpression of IL-13 does not upregulate CAR4 in the absence of pathogenic level of IL-5. Recent research suggests that orally administrated CAR1 positively regulates regulatory T cells and negatively regulates T H 17 cells with a negative impact on inflammatory bowel disease pathogenesis (31), CAR2 and CAR4 are associated with pathogenesis of cystic fibrosis (32) and infectious diarrhea (13), and CAR9 may be associated with gastrointestinal malignancies (33), suggesting a link between CARs and immune regulation.…”

Section: Discussionmentioning

confidence: 99%

Carbonic Anhydrase IV Is Expressed on IL-5–Activated Murine Eosinophils

Wen

Mingler

Wahl

et al. 2014

The Journal of Immunology

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Eosinophilia and its cellular activation are hallmark features of asthma, as well as other allergic/TH2 disorders, yet there are few, if any, reliable surface markers of eosinophil activation. We have employed a FACS-based genome-wide screening system to identify transcriptional alterations in murine lung eosinophils recruited and activated by pulmonary allergen exposure. Using a relatively stringent screen with false-positive correction, we identified 82 candidate genes that could serve as eosinophil activation markers and/or pathogenic effector markers in asthma. Carbonic anhydrase IV (Car4) was a top dysregulated gene with 36-fold induction in allergen-elicited pulmonary eosinophils, which was validated by quantitative PCR, IHC and by flow cytometry. Eosinophil CAR4 expression was kinetically regulated by IL-5 but not IL-13. IL-5 was both necessary and sufficient for induction of eosinophil CAR4. While CAR4-deficient mice did not have a defect in eosinophil recruitment to the lung nor a change in eosinophil pH-buffering capacity, allergen-challenged chimeric mice that contained Car4−/− hematopoietic cells aberrantly expressed a series of genes enriched in biological processes involved in epithelial differentiation, keratinization, and anion exchange. In conclusion, we have determined that eosinophils express CAR4 following IL-5 or allergen exposure, and that CAR4 is involved in regulating the lung transcriptome associated with allergic airway inflammation; as such, CAR4 has potential value for diagnosing and monitoring eosinophilic responses.

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“…In addition, a soluble version of CAIX has been detected in body fluids, including serum and urine 17 . High levels of circulating CAIX have been found in cancer patients, by us 18 and others, although its clinical significance remains unclear 19,20 . The pivotal role of CAIX as a pH regulating enzyme in tumors under hypoxia together with its tissue-specific expression have evoked interest in CAIX as a potential target for cancer therapy.…”

Section: Introductionmentioning

confidence: 92%

Sulfamate inhibitor S4 influences carbonic anhydrase IX ectodomain shedding in colorectal carcinoma cells

Hektoen

Ree

Redalen

et al. 2015

Journal of Enzyme Inhibition and Medicinal Chemistry

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Carbonic anhydrase IX (CAIX) is a pivotal pH regulator under hypoxia, which by its tumorspecific expression represents an attractive target for cancer therapy. Here, we report on effects of the sulfamate CAIX inhibitor S4 (4-(3 0 -(3 00 ,5 00 -dimethylphenyl)ureido)phenyl sulfamate) in colorectal carcinoma cell lines. S4 was administered under experimental hypoxia or normoxia to HT29, KM20L2 and HCT116 cells. Effects on survival, proliferation, pH, lactate extrusion and CAIX protein expression were evaluated. S4 treatment resulted in attenuated hypoxia-induced extracellular acidification and reduced clonogenic survival under hypoxia in HT29 cells. The pH effects were present only in a CO 2 =HCO À 3 -free buffer system and were accompanied by decreased lactate extrusion. The main finding of this work was that S4 treatment caused alterations in CAIX ectodomain shedding. This merits further investigation to understand how sulfamates influence CAIX activity and how such drugs may be of use in cancer treatment.

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Diagnostic and prognostic significance of CA IX and suPAR in gastric cancer

Cited by 42 publications

References 14 publications

The Prognostic Significance of Soluble Urokinase Plasminogen Activator Receptor in Acute Myeloid Leukemia

The Prognostic Significance of Soluble Urokinase Plasminogen Activator Receptor in Acute Myeloid Leukemia

Carbonic Anhydrase IV Is Expressed on IL-5–Activated Murine Eosinophils

Sulfamate inhibitor S4 influences carbonic anhydrase IX ectodomain shedding in colorectal carcinoma cells

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