Diagnostic and Prognostic Significance of Plasma N-Terminal-Pro-Brain Natriuretic Peptide in Decompensated Heart Failure with Preserved Ejection Fraction

Paul, Biju; Soon, Kean; Dunne, James; Pasquale, Carmine G. De

doi:10.1016/j.hlc.2008.06.001

Cited by 19 publications

(9 citation statements)

References 21 publications

(19 reference statements)

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“…Even when most of the patients enrolled meet the criteria for the diagnosis of HFpEF defined by the European Society of Cardiology, levels of NTproBNP were still below the levels that were reported in acutely decompensated HFpEF (37). Our finding of NT-proBNP values at the upper limit of normal despite symptomatic HFpEF with proven diastolic dysfunction is also not unexpected, since the major stimulus for release of BNP and its biologically inactive cleavage product NT-proBNP is ventricular wall stress.…”

mentioning

confidence: 49%

Exercise Training Improves Exercise Capacity and Diastolic Function in Patients With Heart Failure With Preserved Ejection Fraction

Edelmann

Gelbrich

Düngen

et al. 2011

Journal of the American College of Cardiology

582

469

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Exercise training improves exercise capacity and physical dimensions of QoL in HFpEF. This benefit is associated with atrial reverse remodeling and improved left ventricular diastolic function. (Exercise Training in Diastolic Heart Failure-Pilot Study: A Prospective, Randomised, Controlled Study to Determine the Effects of Physical Training on Exercise Capacity and Quality of Life [Ex-DHF-P]; ISRCTN42524037).

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mentioning

confidence: 49%

Exercise Training Improves Exercise Capacity and Diastolic Function in Patients With Heart Failure With Preserved Ejection Fraction

Edelmann

Gelbrich

Düngen

et al. 2011

Journal of the American College of Cardiology

582

469

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“…Brain tissues were removed and processed by Golgi-Cox staining, using procedures described previously [39]. Briefly, brains were first stored in the dark for 14 days in Golgi-Cox solution followed by 3 days in 30% sucrose.…”

Section: Methodsmentioning

confidence: 99%

Cortical Abnormalities and Non-Spatial Learning Deficits in a Mouse Model of CranioFrontoNasal Syndrome

et al. 2014

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Eph receptors and their ephrin ligands play critical roles in the development of the nervous system, however, less is known about their functions in the adult brain. Here, we investigated the function of ephrinB1, an ephrinB family member that is mutated in CranioFrontoNasal Syndrome. We show that ephrinB1 deficient mice (EfnB1Y/−) demonstrate spared spatial learning and memory but exhibit exclusive impairment in non-spatial learning and memory tasks. We established that ephrinB1 does not control learning and memory through direct modulation of synaptic plasticity in adults, since it is not expressed in the adult brain. Rather we show that the cortex of EfnB1Y/− mice displayed supernumerary neurons, with a particular increase in calretinin-positive interneurons. Further, the increased neuron number in EfnB1Y/− mutants correlated with shorter dendritic arborization and decreased spine densities of cortical pyramidal neurons. Our findings indicate that ephrinB1 plays an important role in cortical maturation and that its loss has deleterious consequences on selective cognitive functions in the adult.

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“…Previous studies reporting the association between natriuretic peptides and cardiovascular (CV) outcomes have used a single baseline measurement of BNP or NT‐proBNP . A few studies have examined the significance of change in levels of natriuretic peptides over time, and these have been limited to cohorts of patients with HF and reduced ejection fraction (HF‐REF) or acute decompensated HF . Yet nearly half of all patients with HF have an ejection fraction of >45%, i.e.…”

Section: Introductionmentioning

confidence: 99%

“…3 -6 A few studies have examined the significance of change in levels of natriuretic peptides over time, and these have been limited to cohorts of patients with HF and reduced ejection fraction (HF-REF) 7 -15 or acute decompensated HF. 16 Yet nearly half of all patients with HF have an ejection fraction of >45%, i.e. HF with preserved ejection fraction (HF-PEF).…”

Section: Introductionmentioning

confidence: 99%

Changes in N‐terminal pro‐B‐type natriuretic peptide levels and outcomes in heart failure with preserved ejection fraction: an analysis of the I‐Preserve study

Jhund

Anand

Komajda

et al. 2015

European J of Heart Fail

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Aims In patients with heart failure (HF) and reduced ejection fraction, decreases or increases in NT‐proBNP levels are associated with better and worse outcomes, respectively. The association in HF and preserved ejection fraction (HF‐PEF) is unknown. We examined the association between change in level of NT‐proBNP and prognosis in patients with HF‐PEF. Methods and results We examined the association between change in NT‐proBNP from baseline to 6 months and cardiovascular (CV) death or HF hospitalization in 2612 participants in the Irbesartan in Patients with Heart Failure and Preserved Systolic Function Study (I‐Preserve). Change in NT‐proBNP was modelled as a restricted cubic spline in a Cox model after adjusting for baseline NT‐proBNP and known prognostic variables. Median change in NT‐proBNP from baseline was −7 pg/mL (interquartile range −143 to +108). After adjustment, a 1000 pg/mL decrease in NT‐proBNP from baseline was associated with a reduction in the risk of CV death or HF hospitalization [hazard ratio (HR) 0.73, 95% confidence interval (CI) 0.53–1.02]; a 1000 pg/mL increase was associated with an increase in risk (HR 2.01, 95% CI 1.50–2.69). Beyond a 1000 pg/mL rise or fall, there was little additional change in risk. Addition of change in NT‐proBNP at 6 months to a model with only baseline NT‐proBNP improved the C‐statistic from 0.752 to 0.769 (P = 0.013). Conclusion In HF‐PEF, a rise in NT‐proBNP was associated with an increase in risk of CV death or HF hospitalization and a fall was associated with a trend towards a decrease in risk. NT‐proBNP may be a useful marker to monitor prognosis in this condition.

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Diagnostic and Prognostic Significance of Plasma N-Terminal-Pro-Brain Natriuretic Peptide in Decompensated Heart Failure with Preserved Ejection Fraction

Cited by 19 publications

References 21 publications

Exercise Training Improves Exercise Capacity and Diastolic Function in Patients With Heart Failure With Preserved Ejection Fraction

Exercise Training Improves Exercise Capacity and Diastolic Function in Patients With Heart Failure With Preserved Ejection Fraction

Cortical Abnormalities and Non-Spatial Learning Deficits in a Mouse Model of CranioFrontoNasal Syndrome

Changes in N‐terminal pro‐B‐type natriuretic peptide levels and outcomes in heart failure with preserved ejection fraction: an analysis of the I‐Preserve study

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