Diagnostic and Prognostic Significance of Keap1 mRNA Expression for Lung Cancer Based on Microarray and Clinical Information from Oncomine Database

Liu, Guang-Ya; Zhang, Wei; Chen, Xu-Chi; Wu, Wenjuan; Wan, Shiqian

doi:10.1007/s11596-021-2378-2

Cited by 2 publications

(4 citation statements)

References 43 publications

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“…Considering the difficulty of treatment and poor prognosis of LIHC, it is extremely necessary to provide timely and effective targets for clinical diagnosis and treatment of LIHC, so as to improve the survival time of patients. KEAP1 has been found to be abnormally elevated in many cancers, such as HNSC, LUSC ( 15 , 16 ). In this study, we found that KEAP1 was significantly overexpressed in LIHC patients, and found that KEAP1 has a good diagnostic value for LIHC (AUC = 0.912) with high sensitivity (0.912) and specificity (0.853).…”

Section: Discussionmentioning

confidence: 99%

“…Immune cells are the main body of immune system to perform immune function. They recognize foreign antigens through specific receptors, directly or indirectly eliminate foreign pathogens, mutated tumor cells and damaged senescent cells, and regulate intercellular immunity by secreting related cytokines to transmit specific information, mediating the normal functions of tissues and the body ( 16 ). Therefore, the dysfunction of immune cells may seriously affect the body’s health.…”

Section: Discussionmentioning

confidence: 99%

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KEAP1 overexpression is correlated with poor prognosis and immune infiltration in liver hepatocellular carcinoma

Wei,

Tang,

Zheng

et al. 2024

Front. Med.

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PurposeLiver hepatocellular carcinoma (LIHC) is the most common type of liver cancer, but there is a lack of effective indicators for its early diagnosis and prognosis, so we explored the role of KEAP1 in LIHC patients in this study.MethodsThe Cancer Genome Atlas (TCGA) dataset was used to investigate the relationship between KEAP1 expression and clinicopathological features and prognosis of LIHC patients. KEAP1 expression related pathways were enriched by Gene Ontology (GO) and gene set enrichment analysis (GSEA). Besides, KEAP1 expression-related immune infiltration was performed by single-sample GSEA (ssGSEA), and function of immune cells was detected by flow cytometry.ResultsIt was found that KEAP1 expression was significantly increased and correlated with overall survival of LIHC patients. A total of 231 differentially expressed genes (DEGs) between LIHC patients with high- and low-KEAP1 expression were found, which associated with various biological pathways. Besides, KEAP1 expression was positively correlated with the infiltration level of T helper cells and Th2 cells but negatively correlated with DCs and cytotoxic cells. Functional analysis revealed that the expression of IL 4 in Th2 cells and CD107a, GrA and GrB in cytotoxic cells was significantly greater in LIHC patients than in HCs. In addition, KEAP1 expression was closely correlated with liver function in LIHC patients.ConclusionHighly expressed KEAP1 was closely related to the diagnosis, prognosis, immune cell infiltration, and liver function of LIHC, which might promote the progression of LIHC through regulating cell development, signal transduction, and abnormal immune response. The current study partially revealed the role of KEAP1 in LIHC and provided a potential biomarker for the diagnosis, prognosis and treatment of LIHC.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

KEAP1 overexpression is correlated with poor prognosis and immune infiltration in liver hepatocellular carcinoma

Wei,

Tang,

Zheng

et al. 2024

Front. Med.

View full text Add to dashboard Cite

show abstract

“…Considering the difficulty of treatment and poor prognosis of LIHC, it is extremely necessary to provide timely and effective targets for clinical diagnosis and treatment of LIHC, so as to improve the survival time of patients. KEAP1 has been found to be abnormally elevated in many cancers, such as HNSC, LUSC (15,16). In this study, we found that KEAP1 was significantly overexpressed in LIHC patients, found that KEAP1 has a good diagnostic value for LIHC (AUC = 0.912) with high sensitivity (0.912) and specificity (0.853).…”

Section: Discussionmentioning

confidence: 55%

“…Immune cells are the main body of immune system to perform immune function. They recognize foreign antigens through specific receptors, directly or indirectly eliminate foreign pathogens, mutated tumor cells and damaged senescent cells, and regulate intercellular immunity by secreting related cytokines to transmit specific information, mediating the normal functions of tissues and the body (16). Therefore, the dysfunction of immune cells may seriously affect the body's health.…”

Section: Discussionmentioning

confidence: 99%

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Diagnostic and Prognostic Significance of Keap1 mRNA Expression for Lung Cancer Based on Microarray and Clinical Information from Oncomine Database

Cited by 2 publications

References 43 publications

KEAP1 overexpression is correlated with poor prognosis and immune infiltration in liver hepatocellular carcinoma

KEAP1 overexpression is correlated with poor prognosis and immune infiltration in liver hepatocellular carcinoma

Table_2.XLSX

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