Diagnostic and prognostic role of mean platelet volume and mean platelet volume/platelet ratio in the most common soft tissue sarcomas

Abstract

Objectives This study aims to investigate the diagnostic and prognostic role of mean platelet volume (MPV) and MPV/platelet (PLT) ratio in the most common soft tissue sarcomas. Patients and methods We retrospectively investigated 131 patients (76 males, 55 females; mean age: 51.8±17.1; range, 18 to 87 years) with soft-tissue sarcomas between January 2011 and January 2019. Demographic features, MPV, PLT counts, mortality, and recurrence records of the patients were obtained from archives. A total of 165 healthy volunteers (101 males, 64 females; mean age 52.9±4.1; range, 18 to 60 years) who applied to the outpatient clinic in 2019 and had routine blood control without any additional disease formed the control group. Results A total of 55 patients were diagnosed with liposarcoma and 76 with pleomorphic sarcoma. Of the tumors, 77.1% were located in the lower limbs. Lesions were mostly localized on the thigh 48.8% (n=64). Recurrence occurred in 28.2% of the patients. A total of 25 (19.1%) patients were exitus. The mean follow-up period of the patients was 34.4±19.1 (range, 9 to 112) months. The mean PLT value of the patient group was significantly higher than the control group. The median MPV and MPV/PLT ratio were statistically significantly lower in the patient group than in the control group. The MPV and MPV/PLT ratio were not associated with mortality and recurrence. Conclusion As a result, MPV and MPV/PLT ratio can be used as a diagnostic support parameter in soft tissue sarcomas, but have no prognostic value.

The relationship of systemic inflammatory biomarkers and cardiac parameters with malignancy in patients with soft tissue tumors located in the extremity

“…Values such as neutrophil, lymphocyte, platelet, NLR, PLR, albumin, and total cholesterol are low-cost and easily applicable methods in all patients for routine follow-up before surgery. Recently, Arıkan et al [13] reported that mean platelet volume (MPV) and MPV/platelet ratio are useful in the diagnosis of STS, but did not contribute to the prediction of the prognosis. [13] In recent years, for the approach to benign and malignant tumors, systemic inflammatory biomarkers such as NLR and PLR have emerged as valid alternatives to traditional methods that have been shown to be associated with diagnosis and/or prognosis in different tumor types.…”

“…Recently, Arıkan et al [13] reported that mean platelet volume (MPV) and MPV/platelet ratio are useful in the diagnosis of STS, but did not contribute to the prediction of the prognosis. [13] In recent years, for the approach to benign and malignant tumors, systemic inflammatory biomarkers such as NLR and PLR have emerged as valid alternatives to traditional methods that have been shown to be associated with diagnosis and/or prognosis in different tumor types. [6][7][8] These ratios are easily obtainable values obtained from routine complete blood count without additional economic burden.…”

“…Values such as neutrophil, lymphocyte, platelet, NLR, PLR, albumin, and total cholesterol are low-cost and easily applicable methods in all patients for routine follow-up before surgery. Recently, Arıkan et al[ 13 ] reported that mean platelet volume (MPV) and MPV/platelet ratio are useful in the diagnosis of STS, but did not contribute to the prediction of the prognosis. [ 13 ]…”

“…Recently, Arıkan et al[ 13 ] reported that mean platelet volume (MPV) and MPV/platelet ratio are useful in the diagnosis of STS, but did not contribute to the prediction of the prognosis. [ 13 ]…”

Evaluation of prognostic factors and oncological outcomes in patients with limb-localized myxoid liposarcoma

“…Myxoid liposarcomas are typically localized in the deep soft tissues of the extremities, most often the thigh. [2] Surgical resection is the main treatment modality in MLS, as well as in moderate and high-grade STS. Radiotherapy (RT) also plays an important role in the treatment of limb MLS.…”