Diagnostic and prognostic role of ascitic fluid calprotectin level: six-month outcome findings in cirrhotic patients

Nasereslami, Maryam; Khamnian, Zhila; Moaddab, Yaghoub; Jalali, Zahra

doi:10.1080/00365521.2020.1794023

Cited by 8 publications

(10 citation statements)

References 19 publications

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“…There was no significant relationship between age or sex and mortality. This goes with Popoiag et al (15) , Nasereslami et al (16) , Melcarne et al (17) and Musskopf et al (18) studies. Also, clinical presentation of abdominal pain, tenderness or fever were not associated with mortality which agrees with Popoiag et al (15) results apart from fever which was significantly associated with mortality.…”

Section: Discussionsupporting

confidence: 75%

“…Ascitic fluid protein was significantly higher in survivors which was like what Nasereslami et al (16 ) found, but against Morsy et al (22) and Hassan and Abdel Rehim (23) who found it insignificant. Ascitic fluid WBCs and PMNL were significantly associated with mortality which goes with Nasereslami et al (16 finding but Iliaz et al (12) , Musskopf et al (18) and Morsy et al (22) didn't find that.…”

Section: Discussionsupporting

confidence: 72%

“…Also, clinical presentation of abdominal pain, tenderness or fever were not associated with mortality which agrees with Popoiag et al (15) results apart from fever which was significantly associated with mortality. We found that Child-Pugh score significantly affect mortality in SBP patients, like Iliaz et al (12) , Nasereslami et al (16) , Elzouki et al (19) and Tsung et al (20) results. That was unlike what Wiesner et al (21) and Morsy et al (22) found.…”

Section: Discussionsupporting

confidence: 58%

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Prognostic Factors of Short-Term Mortality in Spontaneous Bacterial Peritonitis Patients

Ahmed

Morsy²,

Mohammad³

2022

The Egyptian Journal of Hospital Medicine

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Introduction:In cirrhotic individuals, spontaneous bacterial peritonitis (SBP) is one of the most frequent side effects. 1year mortality is up to 50% even with strong prevention, early diagnosis, and effective care. Aim: To analyze prognostic factors of short-term mortality in SBP individuals. Patients and Methods: In our study, 92 SBP patients were involved. Prothrombin time, international normalized ratio (INR), liver enzymes, serum albumin, total bilirubin, complete blood count, and serum creatinine were all evaluated. A sample of ascitic fluid was collected for chemical analysis. Follow up of the patients was done during hospital admission for complications and mortality. Results: Significantly correlated with mortality were Child score (P=0.02), MELD score (P=0.003), hepatic encephalopathy (P=0.009), and hepatorenal syndrome (P<0.001) in SBP patients. Patients who died had considerably higher WBCs (P=0.003), serum creatinine levels: basal creatinine (P<0.001), maximum creatinine (P<0.001) and last creatinine (P<0.001), ascitic fluid WBCs (P<0.001) and PMNL count (P<0.001) while platelets (P<0.001), ALT (P<0.001), Serum total bilirubin (P<0.001), ascitic fluid protein (P<0.001) and ascitic fluid albumin (P=0.007) were higher in survivors. Conclusion:In SBP patients, WBCs, serum creatinine, ascitic fluid WBCs and PMNL count, MELD score, Child-Pugh score, hepatic encephalopathy and hepatorenal syndrome were all strongly linked to mortality.

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Section: Discussionsupporting

confidence: 75%

Section: Discussionsupporting

confidence: 72%

Section: Discussionsupporting

confidence: 58%

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Prognostic Factors of Short-Term Mortality in Spontaneous Bacterial Peritonitis Patients

Ahmed

Morsy²,

Mohammad³

2022

The Egyptian Journal of Hospital Medicine

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“…The difference in age and gender among SBP and non-SBP groups wasn't significant, which was like Abdel-Razik et al [7,12] , Makhlouf et al [13] , and Nasereslami et al [14] .…”

Section: Discussionmentioning

confidence: 76%

Diagnostic Value of Ascitic Fluid Homocysteine and Calprotectin in Cirrhotic Patients with Spontaneous Bacterial Peritonitis

Ahmed

Morsy²,

Yousef³

et al. 2022

The Egyptian Journal of Hospital Medicine

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Background and study aim: Spontaneous bacterial peritonitis (SBP) is mainly diagnosed by ascitic polymorphonuclear (PMNL) leukocyte greater than 250/mm 3 . We intended to assess ascitic homocysteine and calprotectin for SBP diagnosis. Materials and methods: In our study, we collected ascitic fluids from 70 patients with liver cirrhosis (46 SBP plus 24 non-SBP according to PMNL>250 cells/mm 3 ). Complete blood count, alanine aminotransferase, aspartate aminotransferase, serum albumin, total bilirubin, prothrombin time, INR, and serum creatinine were measured. Ascitic fluid sample was taken for chemical analysis, homocysteine was calculated in ascites by human homocysteine enzyme-linked immunosorbent assays (ELISA) kits and calprotectin was measured in the ascitic fluids using available human calprotectin enzyme-linked immunosorbent assays (ELISA) kits. Results: SBP patients had considerably greater ascitic homocysteine levels than non-SBP (5.66± 7.15 vs. 2.97±.61 μmol/l) P=0.001. Homocysteine at a cut-off of 3.6 μmol/l had 91.7% specificity, 69.9% sensitivity, PPV 94.1% and NPV 61.1% for SBP diagnosis (area under the curve: 0. 754). SBP patients had considerably greater ascitic calprotectin than the non-SBP (182.98± 76.27 vs. 118.1± 27 ng/mL) P=0.000. Using a cut-off 142 ng/mL, calprotectin had 91.7% specificity, 71.7% sensitivity, PPV 94.2% and NPV 62.9% for SBP diagnosis (area under the curve: 0.768). Conclusion:We found that ascitic homocysteine and calprotectin can be suitable diagnostic markers for SBP diagnosis.

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“…In a study by Yang et al, 9 a significant association was found between dialysate IL‐6 level, a marker showing peritoneal inflammation, and the risk of peritonitis. Also there are studies showing the predictive role of ascitic calprotectin in cirrhotic patients in prognosis and in the diagnosis of spontaneous bacterial peritonitis 26,27 . Our relatively small sample size and few deaths might have contributed to this lack of significance.…”

Section: Discussionmentioning

confidence: 91%

Peritoneal calprotectin level in peritoneal dialysis patients

Sevik

Ataş

Ilgin

et al. 2022

Seminars in Dialysis

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Background: Calprotectin is an important molecule in the initiation and progression of the inflammatory process. Systemic and local intraperitoneal inflammation are distinct processes and consequences in peritoneal dialysis (PD). We aimed to evaluate dialysate calprotectin levels and its associations with peritonitis and dialysis adequacy in PD patients.Methods: Forty-four PD patients were included in this prospective study. Calprotectin concentration was evaluated in 24-h peritoneal drainage fluid. Patients were followed-up for 1 year, and peritonitis episodes were recorded. Dialysate calprotectin levels were compared to dialysis adequacy parameters and peritonitis frequency.Results: The mean age of patients was 54.9±12.7 years. Median PD duration was 54 (23-76) months. Seventeen patients (38.6%) had previous peritonitis episodes.During follow-up, 15 of 44 patients (34.1%) had peritonitis. The median calprotectin concentration was 79.5 (75.2-86.3) ng/ml. The patients were divided into low and high calprotectin groups according to median value. In the high calprotectin group, BMI was found higher (p = 0.04). There was no significant relationship between calprotectin concentration and peritonitis during follow-up (p = 0.29). However, the patients that have had previous peritonitis had higher calprotectin concentrations (p = 0.02). The patients who had higher erythrocyte sedimentation rate (ESR) levels also had higher calprotectin concentrations (p = 0.01). Conclusion:Peritoneal calprotectin concentrations were correlated with higher BMI and ESR, and it was higher in patients with previous peritonitis episodes. To our knowledge, this is the first study to examine the peritoneal calprotectin levels in PD patients. Further studies are needed to determine the use of peritoneal calprotectin as an inflammatory marker in PD. | INTRODUCTIONPeritoneal dialysis (PD) is one of the treatment modalities for endstage renal disease (ESRD) patients. Continuous exposure to bioincompatible PD solutions causes structural and functional alterations in the peritoneal membrane during PD. Increased peritoneal solute transport rate (PSTR) is the most common functional alteration, leading to impaired ultrafiltration, inadequate dialysis, and PD treatment discontinuation. 1 Since adequate dialysis provides more prolonged PD treatment and improves quality of life, higher PSTR is an accepted risk factor for technique failure and mortality in PD patients. 2 Peritonitis is a frequent complication of PD which impairs dialysis adequacy and increases morbidity and mortality in PD patients, and it is the leading cause of technique failure. 3,4 It is essential to determine the patients who are at high risk for peritonitis to prevent peritonitis and adverse outcomes in PD patients.Calprotectin is a 36.5 kD weight, heterocomplex, calcium, and zinc-binding protein secreted from neutrophils, monocytes, epithelial

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Diagnostic and prognostic role of ascitic fluid calprotectin level: six-month outcome findings in cirrhotic patients

Cited by 8 publications

References 19 publications

Prognostic Factors of Short-Term Mortality in Spontaneous Bacterial Peritonitis Patients

Prognostic Factors of Short-Term Mortality in Spontaneous Bacterial Peritonitis Patients

Diagnostic Value of Ascitic Fluid Homocysteine and Calprotectin in Cirrhotic Patients with Spontaneous Bacterial Peritonitis

Peritoneal calprotectin level in peritoneal dialysis patients

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