Diagnostic and prognostic potential of circulating miRNAs for intracranial aneurysms

Gareev, Ilgiz; Beylerli, Ozal; Yang, Guang; Измайлов, А. А.; Shi, Huaizhang; Sun, Jinxian; Zhao, Boxian; Liu, Binbing

doi:10.1007/s10143-020-01427-8

Cited by 16 publications

(12 citation statements)

References 65 publications

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“…miR-NAs can be detected in the cells, tissues, and body fluids such as serum, plasma, tears, urine, or cerebrospinal fluid (CSF) 23 . For this reason, these circulating miRNAs are a novel target for the diagnosis and prognosis of a SAH 24 . Understanding the complete miRNA pathway is important because every miRNA regulates the expression of hundreds of genes 25 .…”

Section: Micrornamentioning

confidence: 99%

MicroRNAs Role in Diagnosis and Treatment of Subarachnoid Hemorrhage

Segherlou¹,

Saldarriga²,

Azizi³

et al. 2023

Preprint

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Subarachnoid hemorrhage (SAH) is most commonly seen in patients over 55 years of age and often results in a loss of many productive years. SAH has a high mortality rate, and sur-vivors often suffer from early and secondary brain injuries. Understanding the pathophysiology of the SAH is crucial to identifying potential therapeutic agents. One promising target for diagno-sis and prognosis of SAH is circulating microRNAs, which regulate gene expression and are in-volved in various physiological and pathological processes. In this review, we discuss the poten-tial of microRNAs as a target for diagnosis, treatment, and prognosis in SAH.

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Section: Micrornamentioning

confidence: 99%

MicroRNAs Role in Diagnosis and Treatment of Subarachnoid Hemorrhage

Segherlou¹,

Saldarriga²,

Azizi³

et al. 2023

Preprint

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“…As a result of this combination, they are resistant to RNAses. For this reason, circulating miRNAs could become potential biomarkers for IA and SAH [ 96 , 97 ].…”

Section: Micrornasmentioning

confidence: 99%

microRNAs in Subarachnoid Hemorrhage (Review of Literature)

Makowska

Smolarz

Romanowicz

2022

JCM

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Recently, many studies have shown that microRNAs (miRNAs) in extracellular bioliquids are strongly associated with subarachnoid hemorrhage (SAH) and its complications. The article presents issues related to the occurrence of subarachnoid hemorrhage (epidemiology, symptoms, differential diagnosis, examination, and treatment of the patient) and a review of current research on the correlation between miRNAs and the complications of SAH. The potential use of miRNAs as biomarkers in the treatment of SAH is presented.

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“…In particular, several protein markers, such as glial fibrillary acidic protein, neuro-specific enolase, and S100 calcium binding protein B, a protein involves in BBB dysfunction and brain lesion [88], are also present in stroke and traumatic brain injury [89,90]. Compared to protein and metabolite biomarkers, the advantages of using miRNAs as biomarkers for aSAH and DBI include tissue/cell type, pathophysiological specificity, and stability in biofluids [91], as well as ease of detection [35,[92][93][94].…”

Section: Current Limitation Of Using Mirnas As Biomarkers For Asah and Its Complicationsmentioning

confidence: 99%

MicroRNAs as Biomarkers for Predicting Complications following Aneurysmal Subarachnoid Hemorrhage

Wang

Springer

Hatton

2021

IJMS

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Aneurysmal subarachnoid hemorrhage (aSAH) is a high mortality hemorrhagic stroke that affects nearly 30,000 patients annually in the United States. Approximately 30% of aSAH patients die during initial hospitalization and those who survive often carry poor prognosis with one in five having permanent physical and/or cognitive disabilities. The poor outcome of aSAH can be the result of the initial catastrophic event or due to the many acute or delayed neurological complications, such as cerebral ischemia, hydrocephalus, and re-bleeding. Unfortunately, no effective biomarker exists to predict or diagnose these complications at a clinically relevant time point when neurologic injury can be effectively treated and managed. Recently, a number of studies have demonstrated that microRNAs (miRNAs) in extracellular biofluids are highly associated with aSAH and complications. Here we provide an overview of the current research on relevant human studies examining the correlation between miRNAs and aSAH complications and discuss the potential application of using miRNAs as biomarkers in aSAH management.

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Diagnostic and prognostic potential of circulating miRNAs for intracranial aneurysms

Cited by 16 publications

References 65 publications

MicroRNAs Role in Diagnosis and Treatment of Subarachnoid Hemorrhage

MicroRNAs Role in Diagnosis and Treatment of Subarachnoid Hemorrhage

microRNAs in Subarachnoid Hemorrhage (Review of Literature)

MicroRNAs as Biomarkers for Predicting Complications following Aneurysmal Subarachnoid Hemorrhage

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