Diagnostic and predictive value of CSF d-ROM level in influenza virus-associated encephalopathy

Yamanaka, Gaku; Kawashima, Hisashi; Suganami, Yusuke; Watanabe, C. K.; Watanabe, Yoshiaki; Miyajima, Tasuku; Takekuma, Kouji; Oguchi, Satoshi; Hoshika, Akinori

doi:10.1016/j.jns.2005.11.029

Cited by 39 publications

(31 citation statements)

References 17 publications

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“…Recent reports suggest that reactive oxygen metabolites (ROMs) in serum are also a reliable biomarker 7, 9, 10) : it has been reported that the ROMs assay was useful to assess the antioxidant treatment strategies 10) and the severity of influenza virus-associated encephalopathy 25) . Furthermore, the ROM assay is relatively inexpensive and can be performed easily in 5 − 7 minutes.…”

Section: Discussionmentioning

confidence: 99%

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Relations between Serum Reactive Oxygen Metabolites (ROMs) and Various Inflammatory and Metabolic Parameters in a Japanese Population

Hara

Kawabe

Komiya

et al. 2009

JAT

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Aim: Both oxidative stress and inflammation are known to play roles in the pathogenesis of cardiovascular disease. We investigated the relations between reactive oxygen metabolites (ROMs) and various inflammatory and metabolic parameters in a Japanese population. Methods: We analyzed 48 male and 69 female subjects, aged 25 to 65 years, who underwent an annual health checkup in our university. Serum ROM level was assayed using a free radical elective evaluator. We also measured serum concentrations of high-sensitivity C-reactive protein (hsCRP), insulin, and high molecular weight (HMW) adiponectin. Results: Although the serum ROM level in females (347 83 Carr U) was slightly higher than in males (333 53 Carr U), this was not statistically significant. In the 48 male subjects, the ROM level

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Section: Discussionmentioning

confidence: 99%

“…; Diacron srl, Italy) 25) . In brief, a 20 L serum sample and 1 mL buffered solution (R2 kit reagent, pH 4.8) were gently mixed in a cuvette, and then 10 L chromogenic substrate (R1 kit reagent) was added to the cuvette.…”

Section: Measurement Of Reactive Oxygen Metabolites (Rom)mentioning

confidence: 99%

Relations between Serum Reactive Oxygen Metabolites (ROMs) and Various Inflammatory and Metabolic Parameters in a Japanese Population

Hara

Kawabe

Komiya

et al. 2009

JAT

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“…The d-ROMs level reflects the intensity of oxidative stress, and the BAP level indicates the activity of endogenous antioxidants [14,15]. Their effectiveness as clinical markers has been reported in various diseases [16,17,18,19,20,21,22]. We evaluated redox states in fresh serum of both patients carrying A3243G and healthy volunteers using d-ROMs and BAP tests, and clarified the change of redox states due to A3243G and the pathophysiological difference in phenotypes with or without stroke-like episodes.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Systemic Redox States in Patients Carrying the MELAS A3243G Mutation in Mitochondrial DNA

Ikawa

Arakawa²,

Hamano³

et al. 2012

Eur Neurol

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Background/Aims: To clarify the change of systemic redox states in patients carrying the A3243G mutation in mitochondrial DNA (A3243G), we evaluated oxidative stress and antioxidant activity in the serum of patients. Methods: Oxidative stress and antioxidant activity in the serum samples obtained from 14 patients carrying A3243G and from 34 healthy controls were analyzed using the diacron-reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) tests, respectively. Results: The mean d-ROMs level of all patients was significantly greater than that of the controls (p < 0.005), and the mean BAP/d-ROMs ratio of all patients was significantly lower than that of the controls (p < 0.02). In the patients with a history of stroke-like episodes (n = 10), both mean d-ROMs and BAP levels were increased compared with those of the controls (both p < 0.01). The mean BAP level of the patients without a history of stroke-like episodes (n = 4) was significantly decreased compared with that of the controls (p < 0.001), but the mean d-ROMs levels were not significantly different. Conclusion: d-ROMs and BAP tests indicated that patients carrying A3243G are always exposed to underlying oxidative stress, even at a remission state of stroke-like episodes.

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“…However, the significance of viral loads in CSF has not fully been investigated, especially in infants below 1 year of age. Free radicals and several cytokines have also been reported to correlate with the severity of viral encephalopathy (2,3). For a better understanding of the role of the viral load, free radicals, and cytokines in viral meningitis, we surveyed those levels in CSF obtained from patients below 1 year of age.…”

Section: Introductionmentioning

confidence: 99%

Viral loads of cerebrospinal fluid in infants with enterovirus meningitis

Kawashima

Ioi

Ishii

et al. 2008

Clinical Laboratory Analysis

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For a better understanding of the role of the viral load, free radicals, and cytokines in viral meningitis, we surveyed cerebrospinal fluid (CSF) obtained from patients below 1 year of age who showed positive for enterovirus. In their first examinations interleukin (IL)-6 and free radicals increased whereas pleocytosis was rarely observed. IL-6 decreased within the short period. Viral loads and free radicals increased simultaneously. IL-6 and free radicals of CSF are helpful for diagnosis and treatment of viral meningitis at an early stage.

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Diagnostic and predictive value of CSF d-ROM level in influenza virus-associated encephalopathy

Cited by 39 publications

References 17 publications

Relations between Serum Reactive Oxygen Metabolites (ROMs) and Various Inflammatory and Metabolic Parameters in a Japanese Population

Relations between Serum Reactive Oxygen Metabolites (ROMs) and Various Inflammatory and Metabolic Parameters in a Japanese Population

Evaluation of Systemic Redox States in Patients Carrying the MELAS A3243G Mutation in Mitochondrial DNA

Viral loads of cerebrospinal fluid in infants with enterovirus meningitis

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