Diagnostic algorithm for ameloblastic carcinoma

Kase, Yoshihiro; Kasamatsu, Atsushi; Saito, Tomoaki; Koike, Kazuhiko; Iyoda, Manabu; Nakashima, Daisuke; Endo‐Sakamoto, Yosuke; Sunohara, Masataka; Shiiba, Masashi; Uzawa, Katsuhiro; Tanzawa, Hideki

doi:10.1002/osi2.1024

Cited by 2 publications

(2 citation statements)

References 21 publications

(22 reference statements)

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“…Ki-67 and p53, markers of tumor cell proliferative activity, are highly expressed in AC. Kase et al proposed diagnostic criteria for AC as a Ki-67 positivity rate of 10% or higher [ 35 ]. In addition, ACs with clear cells have anaplastic features and are more invasive than ACs without clear cells and have higher recurrence and mortality rates [ 36 , 37 ].…”

Section: Discussionmentioning

confidence: 99%

“…Other reports are suggesting that the remaining tissue of the tooth embryo may have originated from the entrapped salivary gland epithelium, but this remains to be clarified [ 31 , 38 ]. Surgical resection is the first choice of treatment for ACs, and the efficacy of radiation chemotherapy has not been established [ 31 , 35 ]. There is no association between prophylactic neck dissection and improved survival, and postoperative radiation therapy has been shown to be beneficial in cases of invasion into the surrounding soft tissue or positive margins [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

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Ameloblastic carcinoma of the mandible: a case report

Ogane

Fujii

Suzuki

et al. 2023

Maxillofac Plast Reconstr Surg

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Background Ameloblastic carcinoma is a malignant form of ameloblastoma and a very rare odontogenic tumor. We report a case of ameloblastic carcinoma that occurred after removal of a right-sided mandibular dental implant. Case presentation A 72-year-old female patient visited her family dentist with a complaint of pain around a lower right implant placed 37 years previously. Although the dental implant was removed with the diagnosis of peri-implantitis, the patient experienced dullness of sensation in the lower lip and was followed up by her dentist, but after no improvement. She was referred to a highly specialized institution where she was diagnosed with osteomyelitis and treated the patient with medication; however, there was no improvement. In addition, granulation was observed in the same area leading to a suspicion of malignancy, and the patient was referred to our oral cancer center. The diagnosis of squamous cell carcinoma was made after a biopsy at our hospital. Under general anesthesia, the patient underwent mandibulectomy, right-sided neck dissection, free flap reconstruction with an anterolateral thigh flap, immediate reconstruction with a metal plate, and tracheostomy. Histological analysis of the resected specimen on hematoxylin and eosin staining showed structures reminiscent of enamel pulp and squamous epithelium in the center of the tumor. The tumor cells were highly atypical, with nuclear staining, hypertrophy, irregular nuclear size, and irregular nuclear shape, all of which were suggestive of cancer. Immunohistochemical analysis showed that Ki-67 was expressed in more than 80% of the targeted area, and the final diagnosis was primary ameloblastic carcinoma. Conclusion After reconstructive flap transplantation, occlusion was re-established using a maxillofacial prosthesis. The patient remained disease-free at the 1-year 3-month follow-up.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Ameloblastic carcinoma of the mandible: a case report

Ogane

Fujii

Suzuki

et al. 2023

Maxillofac Plast Reconstr Surg

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A case of ameloblastic carcinoma of the maxilla

Ohta

Itoi

Ryoke

et al. 2021

Journal of Japan Society for Oral Tumors

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Ameloblastic carcinoma (AC) is a malignant form of ameloblastoma and an extremely rare odontogenic tumor.Herein, we report a case of AC of the maxilla. A 62-year-old woman presented to a dental clinic with tenderness of the right cheek. A panoramic radiograph showed a radiolucency in the right maxilla, and she was referred to another hospital. With a provisional diagnosis of a benign lesion, she underwent surgical removal of the maxillary mass, following which a pathological diagnosis of AC was made. Subsequently, she was referred to our department for further treatment, and she underwent partial maxillectomy. She remained disease-free at 3-year follow-up. We performed a literature review of AC cases reported in the last decade. Of 36 AC cases, 63.9％ were clinically diagnosed as benign lesions ; among them, 52.2％ cases were clinically diagnosed as ameloblastoma. Conversely, 92.6％ cases were diagnosed as malignant lesions on biopsy ; among them, 76％ cases were pathologically diagnosed as AC. These findings suggest that clinical and imaging findings may complicate the differentiation of AC from ameloblastoma ; however, performing a biopsy can help obtain a correct diagnosis, leading to appropriate treatment planning.

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Diagnostic algorithm for ameloblastic carcinoma

Cited by 2 publications

References 21 publications

Ameloblastic carcinoma of the mandible: a case report

Ameloblastic carcinoma of the mandible: a case report

A case of ameloblastic carcinoma of the maxilla

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