Diagnostic accuracy of VIKIA® Rota-Adeno and Premier™ Rotaclone® tests for the detection of rotavirus in Niger

Lagaré, Adamou; Moumouni, Aissatou; Kaplon, Jérôme; Langendorf, Céline; Pothier, Pierre; Grais, Rebecca F.; Issaka, Bassira; Page, Anne‐Laure

doi:10.1186/s13104-017-2832-1

Cited by 9 publications

(4 citation statements)

References 12 publications

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“…An enzyme immunoassay was used for 10 of the 14 study years, whilst immuno-chromatography was utilised between 2005 and 2008. The immuno-chromatographic method used (VIKIA®, Rota-Adeno) has a slightly lower diagnostic accuracy compared to enzyme immunoassay methods [ 52 , 53 ]. However, the pre-vaccine introduction time series spanned 11 years, and since the change in testing practices was not accompanied by a clear non-secular variation in RVGE hospitalisation rates, we would not expect this change to have impacted significantly on effect estimates.…”

Section: Discussionmentioning

confidence: 99%

Rotavirus vaccine impact and socioeconomic deprivation: an interrupted time-series analysis of gastrointestinal disease outcomes across primary and secondary care in the UK

Hungerford

Vivancos

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et al. 2018

BMC Med

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BackgroundRotavirus causes severe gastroenteritis in infants and young children worldwide. The UK introduced the monovalent rotavirus vaccine (Rotarix®) in July 2013. Vaccination is free of charge to parents, with two doses delivered at 8 and 12 weeks of age. We evaluated vaccine impact across a health system in relation to socioeconomic deprivation.MethodsWe used interrupted time-series analyses to assess changes in monthly health-care attendances in Merseyside, UK, for all ages, from July 2013 to June 2016, compared to predicted counterfactual attendances without vaccination spanning 3–11 years pre-vaccine. Outcome measures included laboratory-confirmed rotavirus gastroenteritis (RVGE) hospitalisations, acute gastroenteritis (AGE) hospitalisations, emergency department (ED) attendances for gastrointestinal conditions and consultations for infectious gastroenteritis at community walk-in centres (WIC) and general practices (GP). All analyses were stratified by age. Hospitalisations were additionally stratified by vaccine uptake and small-area-level socioeconomic deprivation.ResultsThe uptake of the first and second doses of rotavirus vaccine was 91.4% (29,108/31,836) and 86.7% (27,594/31,836), respectively. Among children aged < 5 years, the incidence of gastrointestinal disease decreased across all outcomes post-vaccine introduction: 80% (95% confidence interval [CI] 70–87%; p < 0.001) for RVGE hospitalisation, 44% (95% CI 35–53%; p < 0.001) for AGE hospitalisations, 23% (95% CI 11–33%; p < 0.001) for ED, 32% (95% CI 7–50%; p = 0.02) for WIC and 13% (95% CI -3–26%; p = 0.10) for GP. The impact was greatest during the rotavirus season and for vaccine-eligible age groups. In adults aged 65+ years, AGE hospitalisations fell by 25% (95% CI 19–30%; p < 0.001).The pre-vaccine risk of AGE hospitalisation was highest in the most socioeconomically deprived communities (adjusted incident rate ratio 1.57; 95% CI 1.51–1.64; p < 0.001), as was the risk for non-vaccination (adjusted risk ratio 1.54; 95% CI 1.34–1.75; p < 0.001). The rate of AGE hospitalisations averted per 1,000 first doses of vaccine was higher among infants in the most deprived communities compared to the least deprived in 2014/15 (28; 95% CI 25–31 vs. 15; 95% CI 12–17) and in 2015/16 (26; 95% CI 23–30 vs. 13; 95% CI 11–16).ConclusionsFollowing the introduction of rotavirus vaccination, incidence of gastrointestinal disease reduced across the health-care system. Vaccine impact was greatest among the most deprived populations, despite lower vaccine uptake. Prioritising vaccine uptake in socioeconomically deprived communities should give the greatest health benefit in terms of population disease burden.Electronic supplementary materialThe online version of this article (doi:10.1186/s12916-017-0989-z) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Rotavirus vaccine impact and socioeconomic deprivation: an interrupted time-series analysis of gastrointestinal disease outcomes across primary and secondary care in the UK

Hungerford

Vivancos

Read

et al. 2018

BMC Med

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“…VIKIA ® Rota-Adeno (BioMérieux, France) was stated to have high sensitivity (77 -98.8%) and specificity (89 -100.0%) [8][9][10][11][12][13]. The specificity of this study is similar at 91.6%, but for the sensitivity, the result was below those standards at 44.8%.…”

Section: Discussionmentioning

confidence: 45%

“…The sensitivity and specificity of norovirus RDTs are 24 -100% and 62 -100%. Rotavirus RDT are stated to range from 69 -94% and 84 -100%, in sensitivity and specificity, respectively [5][6][7][8][9][10][11][12][13]. In Thailand, the sensitivity and specificity of norovirus RDT range from 74.2 -83.3% and 87.5 -99.5% respectively.…”

Section: Introductionmentioning

confidence: 99%

Accuracy and Cross-Reactivity of Rapid Diagnostic Tests for Norovirus and Rotavirus in a Real Clinical Setting

et al. 2020

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Background: Rapid diagnostic test (RDT) of norovirus and rotavirus is commonly used for outbreak screening and patient management. Varying accuracy of the test and cross-reactivity has been reported and could affect the outcome of management. The primary purpose of this study is to provide the accuracy of norovirus and rotavirus rapid diagnostic tests and to analyze the cross-reactivity of both tests. Materials and Methods: Stool samples collected from every acute diarrhea patient aged <15 years old who was admitted at

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“…Twelve studies with 4407 participants were retrieved [17][18][19][20][21][22][23][24][25][26][27][28]. Figure 1 illustrates the literature search, and Table 1 presents the detailed characteristics of the studies.…”

Section: Resultsmentioning

confidence: 99%

Diagnostic accuracy of rotavirus antigen tests in children: A systematic review and meta‐analysis

Hung¹,

Chen²

2023

Tropical Med Int Health

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Objectives: Rotavirus infection is the leading cause of acute gastroenteritis (AGE) in children. Children with rotavirus infection may have symptoms such as diarrhoea or vomiting. Diarrheal diseases caused by rotavirus and other enteric pathogens cannot be differentiated on the basis of clinical symptoms. Therefore, diagnostic testing is essential to confirm a diagnosis of rotavirus infection. The aim of the meta-analysis is to evaluate the diagnostic accuracy of immunochromatographic rotavirus antigen tests in children. Methods: We searched the PubMed, Embase, Cochrane Library and Google Scholar databases for studies evaluating the diagnostic accuracy of antigen tests for rotavirus in children. We included studies that provided sufficient data to construct a 2 Â 2 table on a per patient basis. The overall sensitivity and specificity of the antigen tests were determined using a bivariate random-effects model. Results: In total, 12 studies with 4407 participants were included in the study. The meta-analysis yielded a pooled sensitivity of 89.2% (95% confidence interval [CI]: 77.4%-95.3%) and pooled specificity of 93.2% (95% CI: 83.8%-97.3%). A subgroup analysis of such tests in children aged ≤5 years yielded a pooled sensitivity of 87.1% and pooled specificity of 91.8%. Another subgroup analysis of high-quality studies involving 820 participants yielded a pooled sensitivity of 92.3% and pooled specificity of 95.2%. Conclusions: Rotavirus antigen tests have high sensitivity for the diagnosis of rotavirus infection in children with AGE. In addition, such tests may be effective for the identification and clinical management of rotavirus infection in children and the prevention of disease progression.

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Diagnostic accuracy of VIKIA® Rota-Adeno and Premier™ Rotaclone® tests for the detection of rotavirus in Niger

Cited by 9 publications

References 12 publications

Rotavirus vaccine impact and socioeconomic deprivation: an interrupted time-series analysis of gastrointestinal disease outcomes across primary and secondary care in the UK

Rotavirus vaccine impact and socioeconomic deprivation: an interrupted time-series analysis of gastrointestinal disease outcomes across primary and secondary care in the UK

Accuracy and Cross-Reactivity of Rapid Diagnostic Tests for Norovirus and Rotavirus in a Real Clinical Setting

Diagnostic accuracy of rotavirus antigen tests in children: A systematic review and meta‐analysis

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