Diagnostic accuracy of ultrasound-guided attenuation parameter as a noninvasive test for steatosis in non-alcoholic fatty liver disease

Kuroda, Hidekatsu; Abe, Tamami; Fujiwara, Yoshitaka; Nagasawa, Takayuki; Takikawa, Yasuhiro

doi:10.1007/s10396-021-01123-0

Cited by 14 publications

(9 citation statements)

References 36 publications

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“…Consistent with recent reports, we confirmed that LS obtained using TE and SWE, was strongly correlated with steatosis obtained using ATI and CAP in the present study 21 , 23 . We also found that the V max of the right portal vein tended to be inversely correlated with LS based on 2D-SWE, whereas its correlation with LS based on TE was significant.…”

Section: Discussionsupporting

confidence: 93%

Comparison of portal vein hemodynamics with ultrasound-based elastography for the prediction of liver fibrosis in patients with chronic liver disease

Yamaguchi

Seko

Sakai

et al. 2023

Sci Rep

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Chronic liver disease includes nonalcoholic fatty liver disease, progresses from steatosis and hepatitis to fibrosis and cirrhosis, with hemodynamic changes in portal blood flow. This study aimed to compare portal vein hemodynamics with liver stiffness (LS) and steatosis and included 28 subjects with chronic liver disease, in whom LS and steatosis were evaluated in the same image employing two elastography techniques: transient elastography (TE) with controlled attenuation parameter (CAP) using a FibroScan and two-dimensional shear-wave elastography (2D-SWE) with attenuation imaging (ATI). Additionally, peak maximum velocity (Vmax) of the right portal vein and spleen stiffness with 2D-SWE were evaluated. A strong positive correlation was present between LS values obtained with TE and 2D-SWE and between the attenuation coefficients of steatosis obtained with CAP and ATI. Additionally, a negative correlation was present between LS values and the Vmax of the right portal vein (r = 0.415, p = 0.031). The optimal Vmax cutoff value for discriminating liver fibrosis with an LS value of > 5 kPa was < 17 cm/s; the ability of Vmax to predict fibrosis was comparable to that of the FIB4-index. Low Vmax of the right portal vein was useful for identifying liver fibrosis in patients with chronic liver disease.

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Section: Discussionsupporting

confidence: 93%

Comparison of portal vein hemodynamics with ultrasound-based elastography for the prediction of liver fibrosis in patients with chronic liver disease

Yamaguchi

Seko

Sakai

et al. 2023

Sci Rep

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“…Several other authors also compared the accuracy of the UGAP with LB as the standard in the quantification of HS in patients with CLD, including NAFLD, and also proved a significant correlation between the UGAP-determined AC and steatosis grade, as is systematically presented in Table 4 [ 72 , 82 , 84 ]. They also compared the efficacy of the UGAP with the CAP, using LB as the refence method, and found the AUROCs of the UGAP in identifying steatosis grades, with significantly better results obtained than with the CAP (0.912 vs 0.842, 0.959 vs 0.817 and 0.924 vs 0.801 for S3) [ 72 , 82 , 84 ]. Bende et al found a positive correlation between the UGAP and CAP values in 179 participants with or without CLD (r = 0.73, p < 0.0001) [ 87 ].…”

Section: Quantitative Ultrasound-based Methodsmentioning

confidence: 96%

“…According to the review by Lewis et al and several subsequently published papers, there are in total 14 studies that have assessed the accuracy of ATI in the quantification of HS compared with the reference methods, as well as their determined cut-offs and AUROC values, which are presented in Table 4 [ 17 , 18 , 19 , 60 , 61 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 ]. Several authors have compared ATI with the CAP, but due to its suboptimal performance in quantifying the liver fat content, the latest WFUMB guidelines recommend against using the CAP as the reference standard [ 3 ].…”

Section: Quantitative Ultrasound-based Methodsmentioning

confidence: 99%

“…The UGAP-determined AC is then automatically calculated using the software or the data are stored on a PC and analyzed later. The average of 10 consecutive measurements is considered as the final result [ 72 , 80 , 82 ].…”

Section: Quantitative Ultrasound-based Methodsmentioning

confidence: 99%

“…Six published studies compared the UGAP-determined AC values with the reference methods in the assessment of steatosis grades, in which the authors established cut-off values that seemed similar to those obtained via ATI [ 72 , 80 , 82 , 83 , 84 , 85 , 86 ].…”

Section: Quantitative Ultrasound-based Methodsmentioning

confidence: 99%

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Ultrasound Methods for the Assessment of Liver Steatosis: A Critical Appraisal

et al. 2022

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The prevalence of the non-alcoholic fatty liver disease has reached major proportions, being estimated to affect one-quarter of the global population. The reference techniques, which include liver biopsy and the magnetic resonance imaging proton density fat fraction, have objective practical and financial limitations to their routine use in the detection and quantification of liver steatosis. Therefore, there has been a rising necessity for the development of new inexpensive, widely applicable and reliable non-invasive diagnostic tools. The controlled attenuation parameter has been considered the point-of-care technique for the assessment of liver steatosis for a long period of time. Recently, many ultrasound (US) system manufacturers have developed proprietary software solutions for the quantification of liver steatosis. Some of these methods have already been extensively tested with very good performance results reported, while others are still under evaluation. This manuscript reviews the currently available US-based methods for diagnosing and grading liver steatosis, including their classification and performance results, with an appraisal of the importance of this armamentarium in daily clinical practice.

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Reliability and stability of ultrasound-guided attenuation parameter in evaluating hepatic steatosis

Zhang,

Luo,

Liu

et al. 2024

J Ultrasound

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Diagnostic accuracy of ultrasound-guided attenuation parameter as a noninvasive test for steatosis in non-alcoholic fatty liver disease

Cited by 14 publications

References 36 publications

Comparison of portal vein hemodynamics with ultrasound-based elastography for the prediction of liver fibrosis in patients with chronic liver disease

Comparison of portal vein hemodynamics with ultrasound-based elastography for the prediction of liver fibrosis in patients with chronic liver disease

Ultrasound Methods for the Assessment of Liver Steatosis: A Critical Appraisal

Reliability and stability of ultrasound-guided attenuation parameter in evaluating hepatic steatosis

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