“…Seventeen studies assessed rivaroxaban measurements in whole blood with ROTEM (Werfen, Bedford, MA, USA) ( 18 , 19 , 23 , 24 , 27 , 28 , 30 , 31 , 34 , 36 , 39 – 41 , 44 , 45 , 47 , 48 ) ( Supplementary Table 2.1 ). A significant correlation between rivaroxaban plasma concentration and duration of clotting time (CT) was shown for EXTEM (strong to very strong correlation) ( 24 , 28 , 30 , 34 , 44 , 45 ), INTEM (moderate to strong correlation) ( 24 , 28 , 30 , 34 , 45 ), NATEM (strong correlation) ( 19 ), FIBTEM (strong correlation) ( 44 ), and HEPTEM (strong correlation) ( 28 ) assays ( Table 1.1 ). One study did not find any significant effect of rivaroxaban on ROTEM parameters ( 31 ).…”