Diagnostic accuracy of the interferon-gamma release assay in acquired immunodeficiency syndrome patients with suspected tuberculosis infection: a meta-analysis

Hao, Chunyan; Nakagawa, Atsushi; Takamori, Mikio; Abe, Seitarou; Ueno, Daisuke; Horita, Nobuyuki; Kato, Seiya; Seki, Nobuhiko

doi:10.1007/s15010-022-01789-9

Cited by 16 publications

(10 citation statements)

References 58 publications

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“…Consistent with the literature [ 17 ], tuberculosis combined with HIV infection is associated with false-negative IGRA results, which may be due to the loss or dysfunction of the MTB-specific T-cell memory response in HIV patients [ 18 ]. Decreased lymphocyte number or abnormal lymphocyte function in patients with connective tissue disease are the main risk factors leading to negative results of the interferon-γ release test [ 19 ], which can also explain our study results.…”

Section: Discussionsupporting

confidence: 82%

Host factors associated with false negative results in an interferon‐γ release assay in adults with active tuberculosis

Liu,

Yang,

Wen

et al. 2023

Heliyon

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Section: Discussionsupporting

confidence: 82%

Host factors associated with false negative results in an interferon‐γ release assay in adults with active tuberculosis

Liu,

Yang,

Wen

et al. 2023

Heliyon

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“…The IGRA is a method to detect latent TB infection. 16 However, this is not a useful tool for confirming the diagnosis because only 40% of participants in our study had a positive IGRA.…”

Section: Discussionmentioning

confidence: 61%

Clinical characteristics and treatment outcomes of tuberculous tenosynovitis of the hand and wrist

Ngoc¹,

Tuan²,

Thinh³

et al. 2023

Int. J. Med. Sci.

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Objective : Vietnam is endemic with tuberculosis (TB), which is highly prevalent in the community. TB tenosynovitis of the wrist and hand is uncommon. Because of its insidious progression and atypical presentations, it is often difficult to diagnose, leading to treatment delays. This study investigates the characteristics of clinical and subclinical signs and treatment outcomes of patients with TB tenosynovitis in Vietnam. Patients and Methods : This prospective longitudinal cross-sectional study included 25 TB tenosynovitis patients in the Rheumatology Clinic at University Medical Center Ho Chi Minh City. The diagnosis was made based on a tuberculous cyst in histopathological specimens. The data were collected through medical history, physical examination, and medical records, including demographics, signs, symptoms, condition duration, and related laboratory tests and imaging. The outcomes of all participants were assessed after 12 months of treatment. Results : The most common symptom of TB tenosynovitis was swelling of the hand and wrist, which was present in all patients. Its other symptoms included mild pain and numbness of the hand in 72% and 24% of patients, respectively. It can affect any site on the hand. Hand ultrasound findings included thickening of the synovial membrane (80%), peritendinous effusion (64%), and soft tissue swelling (88%). Most patients (18/22) had a good outcome after the treatment with anti-tubercular drugs. Conclusions : TB tenosynovitis progression is often insidious. Its most common symptoms are swelling of the hand and mild pain. Ultrasound is a useful tool to support the diagnosis. A histological examination confirms the diagnosis. Most cases respond and have a good outcome after 9-12 months of anti-tuberculosis treatment.

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“…Our finding of a higher magnitude of IL17-than IFNγ-producing CD4 + T cells in HIV-ART upon Mtb300 stimulation is contrary to the impression that IFNγ production is the dominant response to Mtb infection [41]. This may have implications for TB diagnosis since current tests for detection of responses to Mtb antigens rely on IFNγ production, whose sensitivity is variable and is impacted by HIV infection [42]. Recent studies revealed evidence that people who have been exposed to Mtb but remain negative by IFNγ responses have detectable responses to Mtb antigens when other readouts are used [43].…”

Section: Discussionmentioning

confidence: 77%

High-parameter phenotypic characterization reveals a subset of human Th17 cells that preferentially produce IL17 againstM. tuberculosisantigen

Ogongo

Tran

Marzan

et al. 2023

Preprint

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Background: Interleukin 17 producing CD4 T cells contribute to control of Mycobacterium tuberculosis (Mtb) infection in humans; whether infection with Human Immunodeficiency Virus (HIV) disproportionately affects distinct Th17 cell subsets that respond to Mtb are incompletely defined. Methods: We performed high-definition characterization of circulating Mtb-specific Th17 cells by spectral flow cytometry in people with latent TB and treated HIV (HIV-ART). We also measured kynurenine pathway activity in plasma by LC/MS and tested the hypothesis that tryptophan catabolism influences Th17 cell differentiation in this context. Results: We identified two categories of Th17 cells: TH17 (CD4+Vα7.2-CD161+CD26+) and T17 (CD4+Vα7.2-CCR6+CXCR3-) cells that were disproportionately reduced in LTBI with HIV-ART, yet Mtb-responsive IL17-producing CD4 T cells were preserved; we found that IL17-producing CD4 T cells dominate the response to Mtb antigen but not CMV antigen or staphylococcal enterotoxin B (SEB); and tryptophan catabolism negatively correlates with TH17 and T1T17 but not T17 cell frequencies. Conclusions: We found differential effects of ART-suppressed HIV on distinct categories of Th17 cells, that IL17-producing CD4 T cells dominate responses to Mtb but not CMV antigen or SEB, and that kynurenine pathway activity is associated with selective decreases of circulating Th17 cells that may contribute to tuberculosis immunity.

show abstract

Diagnostic accuracy of the interferon-gamma release assay in acquired immunodeficiency syndrome patients with suspected tuberculosis infection: a meta-analysis

Cited by 16 publications

References 58 publications

Host factors associated with false negative results in an interferon‐γ release assay in adults with active tuberculosis

Host factors associated with false negative results in an interferon‐γ release assay in adults with active tuberculosis

Clinical characteristics and treatment outcomes of tuberculous tenosynovitis of the hand and wrist

High-parameter phenotypic characterization reveals a subset of human Th17 cells that preferentially produce IL17 againstM. tuberculosisantigen

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