Diagnostic accuracy of tablet-based software for the detection of concussion

Yang, Suosuo; Flores, Benjamin; Magal, Rotem; Harris, Kyrsti; Gross, Jonathan A.; Ewbank, Amy; Davenport, Sasha; Ormachea, Pablo A.; Nasser, Waleed; Le, Weidong; Peacock, W. Frank; Katz, Yael; Eagleman, David M.

doi:10.1371/journal.pone.0179352

Cited by 27 publications

(36 citation statements)

References 29 publications

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“…To assess the communication between brain areas for movement control, our group developed a touch screen based functional assessment tool using a visuomotor task that incorporates two forms of non-standard mapping: explicit rule integration (strategic control), and implicit spatial vision-to-hand-motion realignment (sensorimotor recalibration). Portable software applications to assess brain function following injury are increasingly being developed, and offer a useful, pragmatic approach to providing information to the user and their caregivers (18)(19)(20)(21)(22). In our task, a basic standard mapping condition has the participant place their finger over a central start target on a vertical touch screen, immediately slide their finger on that same screen directly toward a target that appears, and hold it there.…”

Section: A Failure To Communicate: the Effect Of Mild Brain Injury Onmentioning

confidence: 99%

The Effects of Mild Traumatic Brain Injury on Cognitive-Motor Integration for Skilled Performance

et al. 2020

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Adults exposed to blast and blunt impact often experience mild traumatic brain injury, affecting neural functions related to sensory, cognitive, and motor function. In this perspective article, we will review the effects of impact and blast exposure on functional performance that requires the integration of these sensory, cognitive, and motor control systems. We describe cognitive-motor integration and how it relates to successfully navigating skilled activities crucial for work, duty, sport, and even daily life. We review our research on the behavioral effects of traumatic impact and blast exposure on cognitive-motor integration in both younger and older adults, and the neural networks that are involved in these types of skills. Overall, we have observed impairments in rule-based skilled performance as a function of both physical impact and blast exposure. The extent of these impairments depended on the age at injury and the sex of the individual. It appears, however, that cognitive-motor integration deficits can be mitigated by the level of skill expertise of the affected individual, suggesting that such experience imparts resiliency in the brain networks that underly the control of complex visuomotor performance. Finally, we discuss the next steps needed to comprehensively understand the impact of trauma and blast exposure on functional movement control.

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Section: A Failure To Communicate: the Effect Of Mild Brain Injury Onmentioning

confidence: 99%

The Effects of Mild Traumatic Brain Injury on Cognitive-Motor Integration for Skilled Performance

et al. 2020

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“…A short description of each of the 5 assessments that make-up the BrainCheck battery (V4.0.0) is listed in Table 1. More detailed descriptions may be found in a previous validation study [24] . After completion of the BrainCheck battery, the score of each assessment is calculated using assessment specific measurements by the BrainCheck software (shown in Table 1).…”

Section: Measurementsmentioning

confidence: 99%

“…Prior studies have shown that some computerized cognitive tests demonstrate high accuracy in differentiating dementia patients from healthy participants, but do not have adequate psychometrics to distinguish MCI from dementia [19][20][21][22] . Ideally, computerized cognitive tests would aim to be more rapid and maximize accessibility to This study evaluated BrainCheck, a computerized cognitive test battery previously validated for its diagnostic accuracy for the detection of concussion [24] and dementia-related cognitive decline [25] . BrainCheck is portable, allows for self and remote administration, and can be reimbursed by insurance plans in the US.…”

Section: Introductionmentioning

confidence: 99%

“…p-values are adjusted with the Benjamini-Hochberg method. The BrainCheck Overall Score is a composite of all individual assessments within the BrainCheck battery, representing overall performance (See details in Method 2.4).Using an existing normative population database, partly compiled from controls in previous studies[24,25] , the Overall Score was adjusted for age and the device used to generate the normalized BrainCheck Overall Scores. The normalized BrainCheck Overall Scores differed significantly among these three groups ( p <0.05).…”

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confidence: 99%

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Validation of a Computerized Cognitive Test Battery for Detection of Dementia and Mild Cognitive Impairment

Huang²,

Kim³

et al. 2020

Preprint

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Early detection of dementia is critical for intervention and care planning, but remains difficult. This study evaluated a computerized cognitive testing battery (BrainCheck) for its diagnostic accuracy and ability to distinguish the severity of cognitive impairment. 99 participants diagnosed with Dementia, Mild Cognitive Impairment (MCI), or Normal Cognition (NC) completed the BrainCheck battery. Statistical analyses compared participant’s performance on BrainCheck based on their diagnosis group BrainCheck battery performance showed significant differences between the NC, MCI, and Dementia groups, achieving ≥88% sensitivity/specificity for separating NC from Dementia, and ≥77% sensitivity/specificity in separating the MCI group from NC/Dementia groups. Three-group-classification found true positive rates ≥80% for the NC and Dementia groups and ≥60% for the MCI group. BrainCheck was able to distinguish between diagnoses of Dementia, MCI, and NC, providing a potentially reliable tool for early detection of cognitive impairment.

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“…BrainCheck Sport is a computerized neurocognitive test available on iPad, iPhone, or a desktop browser and was previously validated for its diagnostic accuracy for the detection of concussion [22]. BrainCheck Memory is a modified version of this program that targets dementia-related cognitive decline.…”

Section: Introductionmentioning

confidence: 99%

A Rapid, Mobile Neurocognitive Screening Test to Aid in Identifying Cognitive Impairment and Dementia (BrainCheck): Cohort Study

Groppell¹,

Soto‐Ruiz²,

Flores³

et al. 2019

JMIR Aging

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Background The US population over the age of 65 is expected to double by the year 2050. Concordantly, the incidence of dementia is projected to increase. The subclinical stage of dementia begins years before signs and symptoms appear. Early detection of cognitive impairment and/or cognitive decline may allow for interventions to slow its progression. Furthermore, early detection may allow for implementation of care plans that may affect the quality of life of those affected and their caregivers. Objective We sought to determine the accuracy and validity of BrainCheck Memory as a diagnostic aid for age-related cognitive impairment, as compared against physician diagnosis and other commonly used neurocognitive screening tests, including the Saint Louis University Mental Status (SLUMS) exam, the Mini-Mental State Examination (MMSE), and the Montreal Cognitive Assessment (MoCA). Methods We tested 583 volunteers over the age of 49 from various community centers and living facilities in Houston, Texas. The volunteers were divided into five cohorts: a normative population and four comparison groups for the SLUMS exam, the MMSE, the MoCA, and physician diagnosis. Each comparison group completed their respective assessment and BrainCheck Memory. Results A total of 398 subjects were included in the normative population. A total of 84 participants were in the SLUMS exam cohort, 51 in the MMSE cohort, 35 in the MoCA cohort, and 18 in the physician cohort. BrainCheck Memory assessments were significantly correlated to the SLUMS exam, with coefficients ranging from .5 to .7. Correlation coefficients for the MMSE and BrainCheck and the MoCA and BrainCheck were also significant. Of the 18 subjects evaluated by a physician, 9 (50%) were healthy, 6 (33%) were moderately impaired, and 3 (17%) were severely impaired. A significant difference was found between the severely and moderately impaired subjects and the healthy subjects ( P =.02). We derived a BrainCheck Memory composite score that showed stronger correlations with the standard assessments as compared to the individual BrainCheck assessments. Receiver operating characteristic (ROC) curve analysis of this composite score found a sensitivity of 81% and a specificity of 94%. Conclusions BrainCheck Memory provides a sensitive and specific metric for age-related cognitive impairment in older adults, with the advantages of a mobile, digital, and easy-to-use test. Trial Registration ClinicalTrials.gov NCT03608722; https://clinicaltrials.gov/ct2/show/NCT03608722 (Archived by WebCite at http://www.webcitation.org/76JLoYUGf)

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Diagnostic accuracy of tablet-based software for the detection of concussion

Cited by 27 publications

References 29 publications

The Effects of Mild Traumatic Brain Injury on Cognitive-Motor Integration for Skilled Performance

The Effects of Mild Traumatic Brain Injury on Cognitive-Motor Integration for Skilled Performance

Validation of a Computerized Cognitive Test Battery for Detection of Dementia and Mild Cognitive Impairment

A Rapid, Mobile Neurocognitive Screening Test to Aid in Identifying Cognitive Impairment and Dementia (BrainCheck): Cohort Study

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