Diagnostic accuracy of serum biomarkers for head and neck cancer: A systematic review and meta-analysis

Epidermal growth factor receptor detection in serum and saliva as a diagnostic and prognostic tool in oral cancer

“…Similarly, we observed a reduction of serum EGFR in OSCC patients, but it was not possible to recognize any important impact on survival. Nonetheless, relevant series investigating its diagnostic value for OSCC are still limited and show inconclusive results and contradictory outcomes . These highly heterogeneous findings may be related to lower tumor bulk compared to the other neoplasms investigated (i.e., breast, lung, and ovarian cancer) and, consequently, less impact on serum concentrations of EGFR.…”

“…Different authors already evaluated a series of serum biomarkers to assess their diagnostic accuracy in the detection of OSCC. However, in view of a large number of molecules that show preferential expression in OSCC patients, none have a sufficient cost‐benefit ratio to be introduced in routine clinical practice . On the other hand, the evaluation of salivary markers is a potentially promising noninvasive method, especially for clinical management of OSCC.…”

Tongue Cancer Patients Can be Distinguished from Healthy Controls by Specific N‐Glycopeptides Found in Serum

“…A distinctive clinical problem with HNSCCs is the lack of biomarkers. During the last two decades, several studies have aimed to overcome this shortage . Guerra et al.…”

“…conducted a review of the diagnostic accuracy of different proposed serum biomarkers in 2015 . In the 65 studies included, enzyme‐linked immunosorbent assay (ELISA) was the most used method, others being microarray, quantitative polymerase chain reaction, and liquid chromatography mass spectrometry . Mostly proteins but also DNAs, mRNAs, microRNAs, and metabolites were suggested as potential biomarkers.…”

Squamous Cell Carcinoma Antigen-encoding Genes SERPINB3/B4 as Potentially Useful Markers for the Stratification of HNSCC Tumours

“…Measuring serum concentrations of SCCA constitutes a simple method that has previously been proposed to be of potential use for the diagnosis and follow-up of HNSCC patients (29)(30)(31)(32). While the information gained from serum analysis vs. mRNA levels in tumours are likely different, it is interesting to consider the regulation of SERPINB3/B4 mRNA levels in HNSCC and its potential implications for the use of SCCA.…”