Diagnostic Accuracy of Serum Amyloid A in Acute Appendicitis: A Systematic Review and Meta-Analysis

Shi, Wenhua; Wu, Yizhe; Zhong, Linyu; Huang, Zhibin; Zhong, Minlin; Wang, Jin; Huang, Wujiao; Yi, Xiaojiang; Lu, Xinquan; Yuan, Jing; Huang, Wei; Zhou, Xianshi

doi:10.1089/sur.2021.374

Cited by 3 publications

(2 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…AA remains a complex entity to diagnose, given the great variability of its clinical presentation, the broad differential diagnosis of acute abdomen, and the absence of perfect diagnostic tests [1,2]. Research developed in recent years regarding this matter has identi ed promising diagnostic biomarkers, such as interleukin 6 (IL-6) or serum amyloid A1 (SAA1) [3,4]. It should be noted, however, that these markers often have high processing times and economic costs and are not available in all Emergency Departments.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic performance of serum CA-125 for overall and complicated acute appendicitis: a systematic review and meta-analysis

Arredondo Montero,

Pérez Riveros,

Bueso Asfura

2024

Updates Surg

View full text Add to dashboard Cite

BackgroundThis study aimed to analyze the diagnostic performance of serum CA-125 in acute appendicitis (AA). MethodsThis review was registered in PROSPERO (CRD42023450988). We included prospective or retrospective original clinical studies evaluating the diagnostic performance of serum CA-125 in AA. A search was conducted in PubMed, Web of Science, Scopus, and OVID. Search terms and keywords were: (appendicitis OR appendectomy) AND (CA-125 OR CA125). Two independent reviewers selected the articles and extracted relevant data. Methodological quality was assessed using the QUADAS2 index. A synthesis of the results, standardization of the metrics, and three random-effect meta-analyses were performed. ResultsFive studies with data from 533 participants (including 219 patients with a con rmed diagnosis of AA and 107 controls) were included in this review. The random-effect meta-analysis of serum CA-125 (AA vs controls) included 5 articles (125 AA and 70 controls) and resulted in a non-signi cant mean difference [95% CI] of -6.80 [-20.51,6.92] U/mL (p = 0.33). The meta-analysis by subgroups that included only male patients resulted in a signi cant mean difference [95% CI] of 3.48 [0.46,6.49] U/mL (p = 0.02) ConclusionsAlthough serum CA-125 does not appear to be a good overall marker for the diagnosis of AA, our subgroup analyses show that this marker could be useful for diagnosing AA in males. It also appears to be a potentially useful tool for discriminating complicated and uncomplicated AA. However, the limited number of included studies precludes drawing generalizable conclusions. Future prospective studies focused on males are required to con rm these ndings.Registration: PROSPERO (CRD42023450988).

show abstract

Section: Introductionmentioning

confidence: 99%

Diagnostic performance of serum CA-125 for overall and complicated acute appendicitis: a systematic review and meta-analysis

Arredondo Montero,

Pérez Riveros,

Bueso Asfura

2024

Updates Surg

View full text Add to dashboard Cite

show abstract

“…AA remains a complex entity to diagnose, given the great variability of its clinical presentation, the broad differential diagnosis of acute abdomen, and the absence of perfect diagnostic tests [1,2]. Research developed in recent years regarding this matter has identified promising diagnostic biomarkers, such as interleukin 6 (IL-6) or serum amyloid A1 (SAA1) [3,4]. It should be noted, however, that these markers often have high processing times and economic costs and are not available in all Emergency Departments.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic performance of serum CA-125 for overall and complicated acute appendicitis: a systematic review and meta-analysis

Arredondo Montero,

Pérez Riveros,

Bueso Asfura

2023

Preprint

View full text Add to dashboard Cite

BackgroundThis study aimed to analyze the diagnostic performance of serum CA-125 in acute appendicitis (AA).MethodsThis review was registered in PROSPERO (CRD42023450988). We included prospective or retrospective original clinical studies evaluating the diagnostic performance of serum CA-125 in AA. A search was conducted in PubMed, Web of Science, Scopus, and OVID. Search terms and keywords were: (appendicitis OR appendectomy) AND (CA-125 OR CA125). Two independent reviewers selected the articles and extracted relevant data. Methodological quality was assessed using the QUADAS2 index. A synthesis of the results, standardization of the metrics, and three random-effect meta-analyses were performed.ResultsFive studies with data from 533 participants (including 219 patients with a confirmed diagnosis of AA and 107 controls) were included in this review. The random-effect meta-analysis of serum CA-125 (AA vs controls) included 5 articles (125 AA and 70 controls) and resulted in a non-significant mean difference [95% CI] of −6.80 [−20.51,6.92] U/mL (p=0.33). The meta-analysis by subgroups that included only male patients resulted in a significant mean difference [95% CI] of 3.48 [0.46,6.49] U/mL (p=0.02)ConclusionsAlthough serum CA-125 does not appear to be a good overall marker for the diagnosis of AA, our subgroup analyses show that this marker could be useful for diagnosing AA in males. It also appears to be a potentially useful tool for discriminating complicated and uncomplicated AA. However, the limited number of included studies precludes drawing generalizable conclusions. Future prospective studies focused on males are required to confirm these findings.FundingNoneRegistrationPROSPERO (CRD42023450988).

show abstract

Diagnostic performance of serum CA-125 for overall and complicated acute appendicitis: a systematic review and meta-analysis.

Montero,

Pérez-Riveros,

Asfura

2023

Preprint

View full text Add to dashboard Cite

Background This study aimed to analyze the diagnostic performance of serum CA-125 in acute appendicitis (AA). Methods This review was registered in PROSPERO (CRD42023450988). We included prospective or retrospective original clinical studies evaluating the diagnostic performance of serum CA-125 in AA. A search was conducted in PubMed, Web of Science, Scopus, and OVID. Search terms and keywords were: (appendicitis OR appendectomy) AND (CA-125 OR CA125). Two independent reviewers selected the articles and extracted relevant data. Methodological quality was assessed using the QUADAS2 index. A synthesis of the results, standardization of the metrics, and three random-effect meta-analyses were performed. Results Five studies with data from 533 participants (including 219 patients with a confirmed diagnosis of AA and 107 controls) were included in this review. The random-effect meta-analysis of serum CA-125 (AA vs controls) included 5 articles (125 AA and 70 controls) and resulted in a non-significant mean difference [95% CI] of -6.80 [-20.51,6.92] U/mL (p = 0.33). The meta-analysis by subgroups that included only male patients resulted in a significant mean difference [95% CI] of 3.48 [0.46,6.49] U/mL (p = 0.02) Conclusions Although serum CA-125 does not appear to be a good overall marker for the diagnosis of AA, our subgroup analyses show that this marker could be useful for diagnosing AA in males. It also appears to be a potentially useful tool for discriminating complicated and uncomplicated AA. However, the limited number of included studies precludes drawing generalizable conclusions. Future prospective studies focused on males are required to confirm these findings. Registration: PROSPERO (CRD42023450988).

show abstract

Diagnostic Accuracy of Serum Amyloid A in Acute Appendicitis: A Systematic Review and Meta-Analysis

Cited by 3 publications

References 34 publications

Diagnostic performance of serum CA-125 for overall and complicated acute appendicitis: a systematic review and meta-analysis

Diagnostic performance of serum CA-125 for overall and complicated acute appendicitis: a systematic review and meta-analysis

Diagnostic performance of serum CA-125 for overall and complicated acute appendicitis: a systematic review and meta-analysis

Diagnostic performance of serum CA-125 for overall and complicated acute appendicitis: a systematic review and meta-analysis.

Contact Info

Product

Resources

About