Diagnostic Accuracy of Scanning Laser Polarimetry with Enhanced versus Variable Corneal Compensation

Mai, Tuan; Reus, Nicolaas J.; Lemij, Hans G

doi:10.1016/j.ophtha.2007.01.022

Cited by 51 publications

(71 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We have recently demonstrated how a control cohort with no suspicious findings of glaucoma can affect the diagnostic ability of SDOCT parameters in glaucoma compared with a control cohort which is likely to be misinterpreted as glaucoma. 16 Due to the same reason, AUCs of RNFL parameters reported in our study are also lower compared with the studies that have reported the same with SDOCT 7,10,29 and GDx ECC 5,12,13,30 separately.…”

Section: Discussioncontrasting

confidence: 45%

“…The amount of birefringence bias is then mathematically removed point by point from the total 1 VST Glaucoma Center, L V Prasad Eye Institute, Hyderabad, India 2 Center for Clinical Epidemiology and Biostatistics, L V Prasad Eye Institute, Hyderabad, India birefringence pattern of the image to improve the signal and obtain a retardation pattern of the RNFL with the least noise. [4][5][6] Though numerous studies have reported good diagnostic ability of both SDOCT [7][8][9][10][11] and GDx ECC 12,13 in glaucoma, there is limited literature on the head-to-head comparison of these imaging techniques in the same population. 14,15 Also, most of these studies have employed a case-control design including glaucoma patients (cases), defined based on the presence of repeatable characteristic glaucomatous visual field (VF) defects; and normal subjects (controls), usually recruited from the general population and having normal intraocular pressures (IOPs), healthy appearance of the optic nerve and normal VFs.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Retinal nerve fiber layer evaluation of spectral domain optical coherence tomograph and scanning laser polarimeter to diagnose glaucoma

Rao

Yadav

Addepalli

et al. 2014

Eye

View full text Add to dashboard Cite

Purpose To compare the abilities of retinal nerve fiber layer (RNFL) parameters of spectral domain optical coherence tomograph (SDOCT) and scanning laser polarimeter (GDx enhanced corneal compensation; ECC) in detecting glaucoma. Methods In a cross-sectional study, 215 eyes of 165 subjects (106 eyes of 79 glaucoma patients and 109 eyes of 86 controls) referred by general ophthalmologists for glaucoma evaluation underwent RNFL imaging with SDOCT and GDx ECC. Ability of RNFL parameters of SDOCT to discriminate glaucoma eyes from control eyes was compared with that of GDx ECC using area under operating characteristic curves (AUCs), sensitivities at fixed specificities, and likelihood ratios (LRs). Results AUC of the average RNFL thickness of SDOCT to differentiate glaucoma from control eyes (0.868) was comparable (P ¼ 0.32) to that of GDx ECC (0.855). Sensitivity at 95% specificity was 63.2% for average RNFL thickness of SDOCT and 48.1% for the average RNFL measurement of GDx ECC. LRs of outside normal limits category of SDOCT parameters ranged between 5.6 and 7.7 while the same of GDx ECC parameters ranged between 3.1 and 3.7. LRs of within normal limits category of SDOCT parameters ranged between 0.18 and 0.24 while the same of GDx ECC parameters ranged between 0.20 and 0.32. Conclusion Though AUCs and sensitivities at fixed specificities were comparable between the RNFL parameters of SDOCT and GDx ECC in diagnosing glaucoma, LRs indicated that the RNFL parameters of SDOCT were better in 'ruling in' glaucoma.

show abstract

Section: Discussioncontrasting

confidence: 45%

Section: Introductionmentioning

confidence: 99%

Retinal nerve fiber layer evaluation of spectral domain optical coherence tomograph and scanning laser polarimeter to diagnose glaucoma

Rao

Yadav

Addepalli

et al. 2014

Eye

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 93%

“…[11][12][13][14]16 ARP is a pattern of retardation, which do not match the histological distribution of RNFL thickness with thicker RNFL in the superior and inferior regions compared with the temporal and nasal regions. Recently, some clinical aspects of ARP have been reported, including the prevalence of ARP in normal and glaucomatous eyes 9,13,16 and the impact of ARP on the performance of glaucoma diagnosis. [11][12][13][14] The enhanced corneal compensation (ECC) has been developed as an alternative algorithm to the variable corneal compensation (VCC) method to improve the signal-to-noise ratio and eliminate artefacts associated with ARP.…”

Section: Introductionmentioning

confidence: 93%

“…In measurements, scanning laser polarimetry (SLP, GDx; Carl Zeiss Meditec, Dublin, CA, USA), atypical retardation (ie, birefringence) pattern (ARP) is sometimes found and the presence of ARP often makes it difficult to properly evaluate the SLP results, [6][7][8][9][10][11][12][13][14][15][16] resulting in poorer performance in glaucoma diagnosis. [11][12][13][14]16 ARP is a pattern of retardation, which do not match the histological distribution of RNFL thickness with thicker RNFL in the superior and inferior regions compared with the temporal and nasal regions.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Atypical retardation pattern in measurements of scanning laser polarimetry and its relating factors

Yanagisawa

Tomidokoro

Saito

et al. 2008

Eye

View full text Add to dashboard Cite

Purpose To assess the prevalence of atypical retardation pattern (ARP) in scanning laser polarimetry (SLP) with variable corneal compensation (VCC) and enhanced corneal compensation (ECC), and to evaluate the factors relating to typical scan score (TSS). Methods Measurements of SLP-VCC, SLP-ECC, and the Humphrey field analyzer (HFA) were performed in 105 normal subjects and 82 open-angle glaucoma (OAG) patients. ARP was defined as an SLP image with TSSo80.

show abstract

Longitudinal Measurement Variability of Corneal Birefringence and Retinal Nerve Fiber Layer Thickness in Scanning Laser Polarimetry With Variable Corneal Compensation

Lemij

2008

Archives of Ophthalmology

View full text Add to dashboard Cite

To investigate the longitudinal corneal birefringence (corneal polarization axis [CPA] and corneal polarization magnitude [CPM]) variability in scanning laser polarimetry with variable corneal compensation and its effect on retinal nerve fiber layer measurements.Method: We analyzed scanning laser polarimetry images obtained every 6 months for 3.2 years in 16 healthy eyes, 38 eyes with ocular hypertension, and 53 eyes with glaucoma in 107 white participants. Differences in values between each intraeye CPA and CPM measurement and the first measurement were used to investigate the variability and any trend with time, and any association with age or diagnosis. We also calculated the percentage of these values within the range of ±5°or ±5 nm, respectively. Any effect of corneal birefringence variability on the retinal nerve fiber layer measurements was also evaluated. Results:The CPA and CPM measurement variability showed no trend with time and did not differ between diagnostic groups. It did not appear to be affected by age. With more than 90% of the CPA and CPM measurement variability within the range of ±5°or ±5 nm, no significant effect on the retinal nerve fiber layer measurements was observed. Conclusions:The CPA and CPM measurement variability did not differ between groups, showed no trend over time, was independent of subject age, and did not seem to systematically affect retinal nerve fiber layer reproducibility.

show abstract

Diagnostic Accuracy of Scanning Laser Polarimetry with Enhanced versus Variable Corneal Compensation

Cited by 51 publications

References 24 publications

Retinal nerve fiber layer evaluation of spectral domain optical coherence tomograph and scanning laser polarimeter to diagnose glaucoma

Retinal nerve fiber layer evaluation of spectral domain optical coherence tomograph and scanning laser polarimeter to diagnose glaucoma

Atypical retardation pattern in measurements of scanning laser polarimetry and its relating factors

Longitudinal Measurement Variability of Corneal Birefringence and Retinal Nerve Fiber Layer Thickness in Scanning Laser Polarimetry With Variable Corneal Compensation

Contact Info

Product

Resources

About