Diagnostic accuracy of SARS-CoV-2 antigen test in the pediatric population: A systematic review and meta-analysis

Chen, Cheng‐Chieh; Chen, Shih-Yen; Fang, Shiuh-Bin; Lu, Shou-Cheng; Bai, Chyi‐Huey; Wang, Yuan–Hung

doi:10.1016/j.pedneo.2022.07.012

Cited by 4 publications

(3 citation statements)

References 36 publications

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“…Otherwise, in another study [ 14 ] carried out on 1620 symptomatic pediatric patients in a low-prevalence setting (5%), an overall sensitivity of 45.4% was observed. Overall, the RDT showed moderate sensitivity (65.9%, 95% CI: 52.8–77.0%) and high specificity (99.9%) for the detection of SARS-CoV-2 in children [ 27 ]. Nevertheless, it should be noted that all the abovementioned studies were based on comparison of first- and second-generation immunochromatographic tests to the RT-qPCR assay.…”

Section: Discussionmentioning

confidence: 99%

Application of a SARS-CoV-2 Antigen Rapid Immunoassay Based on Active Microfluidic Technology in a Setting of Children and Young Adults

Leli,

Ferrara,

Bottino

et al. 2023

Viruses

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To carry out effective and quick identification of SARS-CoV-2 from nasopharyngeal swabs and contain outbreaks, reliable and rapid tools are needed. Herein, we compared a rapid antigen test based on active microfluidic technology to an RT-qPCR assay in pediatric and young adult patients admitted to the Pediatric Emergency Unit of a Children’s Hospital. Nasopharyngeal swabs collected from patients with suspected COVID-19 disease and from those without COVID-19 related symptoms, but requiring hospitalization, were performed with both antigen test and RT-qPCR assays. We included 375 patients with a median age of 5 years in the study, with an estimated overall prevalence of 7.2%. Overall, we observed a specificity of 97.4% (95% CI: 94.9–98.7) and a sensitivity of 66.6% (95% CI: 46.0–82.7) with a positive likelihood ratio (LR+) of 25.8 (95% CI: 12.8–51.8). In the subgroup of symptomatic patients, the specificity and the sensitivity were 95.2% (95% CI: 89.4–98.0) and 80.0% (95% CI: 44.2–96.5) respectively; LR+ was 16.6 (95% CI: 7.19–38.6). In the asymptomatic subset, the performance showed a specificity of 98.7% (95% CI: 95.8–99.7), a sensitivity of 58.8% (95% CI: 33.5–80.6), and an LR+ of 43.7 (95% CI: 13.3–144.0). Compared to RT-qPCR, the new microfluidic-based antigen test showed higher specificity (>95%) in the pediatric population, thus representing a suitable point-of-care testing (POCT) in a clinical setting with low prevalence of COVID-19.

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Section: Discussionmentioning

confidence: 99%

Application of a SARS-CoV-2 Antigen Rapid Immunoassay Based on Active Microfluidic Technology in a Setting of Children and Young Adults

Leli,

Ferrara,

Bottino

et al. 2023

Viruses

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“…Most often presented in a lateral flow immunoassay (LFIA) format, antigen-detection rapid diagnostic tests (Ag-RDTs) are used to diagnose current SARS-CoV-2 infection. Test sensitivity is higher when performed within five to seven days after symptoms onset [163,164]. Given the brief window of opportunity to provide life-saving treatments, such as Paxlovid, antigen tests might profile as a suitable alternative for timely diagnosis.…”

Section: Types Of Tests Available For Detecting Covid-19mentioning

confidence: 99%

Differential Diagnosis in the Management of Acute Respiratory Infections through Point-of-Care Rapid Testing in a Post-Pandemic Scenario in Latin America: Special Focus on COVID-19, Influenza, and Respiratory Syncytial Virus

Alvarez-Moreno,

de Araújo,

Baumeister

et al. 2024

COVID

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This review provides a comprehensive summary of evidence to explore the role and value of differential diagnosis in the management of Acute Respiratory Infections (ARIs) through point-of-care (POC) rapid testing in a post-pandemic scenario, paying particular attention to coronavirus disease 2019 (COVID-19), influenza, and respiratory syncytial virus (RSV). The document builds on a review of literature and policies and a process of validation and feedback by a group of seven experts from Latin America (LATAM). Evidence was collected to understand scientific and policy perspectives on the differential diagnosis of ARIs and POC rapid testing, with a focus on seven countries: Argentina, Brazil, Chile, Colombia, Costa Rica, Mexico, and Peru. The evidence indicates that POC rapid testing can serve to improve ARI case management, epidemiological surveillance, research and innovation, and evidence-based decision-making. With multiple types of rapid tests available for POC, decisions regarding which tests to use require the consideration of the testing purpose, available resources, and test characteristics regarding accuracy, accessibility, affordability, and results turnaround time. Based on the understanding of the current situation, this document provides a set of recommendations for the implementation of POC rapid testing in LATAM, supporting decision-making and guiding efforts by a broad range of stakeholders.

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“…It is noteworthy that all 116 patients who underwent the RT-PCR tested negative when subjected to the rapid antigen test. The fi ndings suggest that the RT-PCR test and Rapid Antigen test yielded diff erent results, indicating a discrepancy in their diagnostic accuracy for detecting SARS-CoV-2 infection among pediatric patients (11). These results have important implications for clinical decisionmaking and patient management (12).…”

Section: Figure 1 Case Distribution By Agementioning

confidence: 99%

Clinical Manifestations and Diagnosis of COVID-19 in Pediatric Patients: A Retrospective Study

Chisnoiu,

Mihai,

Balasa

et al. 2022

ARS Medica Tomitana

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This retrospective study explores the clinical manifestations and diagnosis of COVID-19 in pediatric patients, focusing on the presentation of mild symptoms. The study was conducted at a tertiary care center and included a cohort of 200 pediatric patients diagnosed with COVID-19. Analysis of the data revealed distinct age distribution patterns, with the highest proportion of cases observed in the 0-1 age group, followed by patients aged 1-2 years. The most prevalent symptoms at the onset of the disease included mild manifestations such as fever, upper respiratory symptomatology, and digestive symptoms. Additionally, a smaller subset of patients exhibited neurological symptoms, lower respiratory symptoms, and renal manifestations in the form of oliguria. Diagnostic methods employed encompassed RT-PCR and Rapid Antigen tests, with notable differences in their effectiveness. Notably, patients presenting with fever experienced a longer duration of hospitalization compared to those without fever. These findings contribute to our understanding of the clinical characteristics of mild COVID-19 cases in pediatric patients and emphasize the importance of early diagnosis and appropriate management strategies.

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Diagnostic accuracy of SARS-CoV-2 antigen test in the pediatric population: A systematic review and meta-analysis

Cited by 4 publications

References 36 publications

Application of a SARS-CoV-2 Antigen Rapid Immunoassay Based on Active Microfluidic Technology in a Setting of Children and Young Adults

Application of a SARS-CoV-2 Antigen Rapid Immunoassay Based on Active Microfluidic Technology in a Setting of Children and Young Adults

Differential Diagnosis in the Management of Acute Respiratory Infections through Point-of-Care Rapid Testing in a Post-Pandemic Scenario in Latin America: Special Focus on COVID-19, Influenza, and Respiratory Syncytial Virus

Clinical Manifestations and Diagnosis of COVID-19 in Pediatric Patients: A Retrospective Study

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