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Abstract: Background and Objectives: To establish the diagnostic accuracy of the markers of neutrophil activity (elastase and lysozyme) determined in pleural fluid, for differentiating between pyogenic bacterial infectious and non-infectious pleural effusions. Patients and Methods: At our tertiary referral teaching hospital, 160 patients over 14 years with pleural effusion (PE), classified as pyogenic bacterial infectious (41 parapneumonic complicated, 32 parapneumonic non-complicated) and non-infectious (32 neoplasm an… Show more

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Cited by 12 publications
(14 citation statements)
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References 19 publications
(14 reference statements)
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“…These findings concur with results from other studies and indicate that in infectious pleural effusions, particularly empyema, there is an intense inflammatory response and inhibition of fibrinolysis that would favour fibrin deposition [10,[12][13][14][15][16].…”
Section: Inflammatory and Fibrinolytic Markers In Pleural Fluidsupporting
confidence: 91%
See 1 more Smart Citation
“…These findings concur with results from other studies and indicate that in infectious pleural effusions, particularly empyema, there is an intense inflammatory response and inhibition of fibrinolysis that would favour fibrin deposition [10,[12][13][14][15][16].…”
Section: Inflammatory and Fibrinolytic Markers In Pleural Fluidsupporting
confidence: 91%
“…The inflammatory response initiated by the mesothelium provokes increased vascular patency and the release of inflammatory mediators, e.g. interleukin (IL)-8 and tumour necrosis factor alpha (TNF)-a [11][12][13], thereby favouring the formation of exudative pleural effusion, invasion of the pleural space by inflammatory cells and the release of neutrophil degranulation products, such as polymorphonuclear elastase (PMN-E) [14]. The fibrinolytic system is regulated by two plasminogen activators (PAs), tissue PA (t-PA) and urokinase PA (u-PA), and by plasminogen activator inhibitor type 1 (PAI-1) and 2 (PAI-2).…”
mentioning
confidence: 99%
“…A number of studies have evaluated the clinical utility of several biomarkers to serve as noninvasive diagnostic tools and differentiate infectious from noninfectious pleural effusions. Although some of them seem to be promising [34, 35], their applicability is still in its infancy. Further studies are warranted to establish their usefulness.…”
Section: Rheumatoid Arthritismentioning
confidence: 99%
“…Polymorphonuclear elastase (PMN-E), a protease that originates from azurophil granules of the polymorphonuclear leukocytes (neutrophils) in response to the release of inflammatory mediators, stands out among these [7]. The value of pleuralfluid PMN-E in the differentiation between infective and noninfective effusions has recently been established [8]. Myeloperoxidase (MPO) is a protein responsible for the peroxidase activity characteristic of the azurophilic granules and is essential for the oxidative mechanism of the phagocytes.…”
mentioning
confidence: 99%