Diagnostic accuracy of nucleic acid amplification tests for tuberculous meningitis: a systematic review and meta-analysis

Colorimetric microwell plate reverse-hybridization assay for Mycobacterium tuberculosis detection

“…The overall sensitivity (87%) and specificity (99%) results obtained in this study are in agreement with the findings of other studies and are also comparable with commercial kits (Pai et al 2003, Piersimoni & Scarparo 2003, Ling et al 2008. The sensitivity and specificity using the spontaneous sputum samples was high; 94% and 100%, respectively.…”

“…There is a high degree of variability in accuracy across studies using NAA tests; thus, they cannot replace culture and microscopy but should be interpreted along with conventional tests and clinical data for diagnosing TB (Pai et al 2003, Piersimoni & Scarparo 2003, CDC 2009). …”

A case of cerebral tuberculoma mimicking neurocysticercosis

“…Therefore, we needed to consider other diseases than neurocysticercosis. Although the CSF PCR for tuberculous meningitis was negative, its sensitivity is only 56%,7 and a diagnosis of cerebral tuberculoma could not be excluded. In retrospect, despite antituberculosis drugs being associated with a high risk of adverse effects, antituberculous chemotherapy should be started before the definitive diagnosis, because tuberculoma is a fatal disease.…”

Aberrant Methylation of Genes in Sputum Samples as Diagnostic Biomarkers for Non-small Cell Lung Cancer: a Meta-analysis

“…A P value of less than 0.1 for the slope coefficient was considered as significant asymmetry, which indicated potential publication bias (Pai et al, 2003).…”