Diagnostic accuracy of MALDI-TOF mass spectrometry for non-small cell lung cancer: a meta-analysis

Lu, Zhaolian; Chen, Yingjian; Jing, Xin-yan; Hu, Chengjin

doi:10.1080/1354750x.2017.1420822

Cited by 2 publications

(1 citation statement)

References 35 publications

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“…All these feature makes MALDI the ideal technique for routine clinical analysis, as demonstrated by the huge number of existing applications for diagnostic purposes [ 19 , 20 , 21 ]. MALDI has indeed demonstrated a great potential when applied to the fight against cancer [ 22 ], and part of the huge amount of work performed on tumor-related topics, including the analysis of drugs [ 23 ], MALDI-imaging developments [ 24 , 25 ], diagnosis of ovarian [ 26 ], non-small cell lung [ 27 ], and prostate [ 28 ] cancer, has very recently been reviewed.…”

Section: Introductionmentioning

confidence: 99%

MALDI-TOF/MS Analysis of Non-Invasive Human Urine and Saliva Samples for the Identification of New Cancer Biomarkers

Zambonin

Aresta

2022

Molecules

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Cancer represents a group of heterogeneous diseases that are a leading global cause of death. Even though mortality has decreased in the past thirty years for different reasons, most patients are still diagnosed at the advanced stage, with limited therapeutic choices and poor outcomes. Moreover, the majority of cancers are detected using invasive painful methods, such as endoscopic biopsy, making the development of non-invasive or minimally invasive methods for the discovery and fast detection of specific biomarkers a crucial need. Among body fluids, a valuable non-invasive alternative to tissue biopsy, the most accessible and least invasive are undoubtedly urine and saliva. They are easily retrievable complex fluids containing a large variety of endogenous compounds that may provide information on the physiological condition of the body. The combined analysis of these fluids with matrix-assisted laser desorption ionization–time-of-flight mass spectrometry (MALDI-TOF/MS), a reliable and easy-to-use instrumentation that provides information with relatively simple sample pretreatments, could represent the ideal option to rapidly achieve fast early stage diagnosis of tumors and their real-time monitoring. On this basis, the present review summarizes the recently reported applications relevant to the MALDI analysis of human urine and saliva samples.

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