Diagnostic accuracy of laboratory markers for diagnosis of acute appendicitis in children

Background: Mean Platelet Volume (MPV) has been suggested as a biomarker for acute appendicitis (AA) in the adult population. The utility of MPV in pediatric AA remains vague. This systematic review and meta-analysis aimed to systematically summarize and compare all relevant data on MPV as a diagnostic biomarker for AA in children. Methods: Databases were systematically searched using keywords ((mean platelet volume) OR mpv) AND (appendicitis). The inclusion criteria were all comparative studies of MPV in children aged less than 18 years and diagnosed with AA. Two authors independently assessed the methodological quality using the Downs and Black scale. Results: We included fourteen studies in the final meta-analysis; most were retrospective. Eight studies compared the MPV values between AA and non-AA; four studies compared the same between AA and healthy controls; two studies compared the MPV values among all three groups. The estimated heterogeneity among the studies for all outcomes was high and statistically significant. The pooling the data showed no statistically significant difference in MPV (weighted mean difference (WMD) = −0.42, 95% CI = (−1.04, 0.20), p = 0.19) between AA and healthy controls or AA and non-AA cases (WMD = 0.01, 95% CI = (−0.15, 0.17), p = 0.90). Conclusion: While MPV levels seem to have some utility in adult AA diagnosis, MPV levels should not dictate treatment options in pediatric AA.

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“…This retrospective study was conducted in Iran [ 25 ]. A total of 100 patients (50 with AA and 50 with non-AA) were studied.…”

Section: Resultsmentioning

confidence: 99%

Mean Platelet Volume in the Diagnosis of Acute Appendicitis in the Pediatric Population: A Systematic Review and Meta-Analysis

et al. 2022

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“…The study also revealed that, when AA were compared to healthy controls, the MPV levels were considerably lower in AA (p<0.001) [28] . In addition, Dooki et al [29] investigated 100 patients in total (fifty with AA and fifty without AA). According to the study, there was a substantial (p<0.001) difference between the mean MPV values of children with non-AA and those with AA.…”

Section: Discussionmentioning

confidence: 99%

Mean Platelet Volume versus Alvarado Score as Predictor of Acute Appendicitis

2023

The Egyptian Journal of Hospital Medicine

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Background: For assisting in the early identification of acute appendicitis (AA) and its prompt therapy, several grading systems have been utilized. Because it takes into account the patient symptoms, findings, and laboratory assessment, the Alvarado score was chosen. Mean platelet volume (MPV) variations could be a sign of production of platelet in addition, a sign of changes in the severity of a number of disorders.Objective: This study aimed to compare MPV and Alvarado score to assess the predictive value for acute appendicitis. Patients and Methods: At the Emergency Hospital Mansoura University, Egypt, a prospective observational cohort research was conducted. 118 participants from both sexes who had right iliac fossa (RIF) pain suggestive of appendicitis participated in this study. Results: when compared to the histological findings, the Alvarado score exhibited a sensitivity and specificity of 67.6% and 61.5% respectively, with an accuracy of 58.5% in diagnosing appendicitis. With an accuracy of 79.7%, ultrasonography demonstrated a sensitivity and specificity of 80.4% and 76.9% in detecting appendicitis respectively. When compared to those without appendicitis, the MPV in cases with AA was statistically considerably smaller. The optimum MPV cutoff point for detecting appendicitis cases was less-than 8.92 with a sensitivity of 78.3%, specificity of 61.5%, and accuracy of 66.2%. Conclusion:While the Alvarado score and the combination of the two exhibited lower accuracy, the MPV had a greater accuracy for diagnosis than the Alvarado score. The sensitivity and accuracy of diagnosing acute appendicitis were significantly improved by combining the Alvarado score with the ultrasound examination.

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“…Acute appendicitis (AA) is the most common surgical condition requiring emergency surgery worldwide 19 . According to Global burden of disease 2013, AA is the most common diagnosis in patients seeking medical help in the emergency room due to acute abdomen causing 72,000 deaths among 16 million cases reported globally 11 . The lifetime risk of AA is 16.33% for males and 16.34% for females in South Korea 20 .…”

Section: Discussionmentioning

confidence: 99%

“…Still, for the C-reactive protein, which is an acute phase protein and elevated level in the acute stage of the disease in acute appendicitis, the CRP level specificity and sensitivity in serum is 98% and 87.5% respectively, with predictive value test almost 98% and that negative test in the range of 87.5% 9,10 . Erythrocyte Sedimentation Rate (ESR) is another marker of inflammation 11 . Its levels are expected to rise in chronic infections.…”

Section: Introductionmentioning

confidence: 99%

Socioeconomic, Laboratory and Associated Factors in Patients Suffering From Acute Appendicitis

Tahir¹,

Ali²,

Usman³

et al. 2023

PJMHS

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Background: Acute appendicitis (AA) is the most common clinical condition worldwide. In Pakistan, about 400,000 appendectomies are routinely carried out in surgical departments yearly. This study aims to find the latest and updated information regarding the diagnostic accuracy of CRP levels in AA. This will help surgeons make timely decisions, thus reducing the morbidity and mortality associated with complicated appendicitis. Methods: This descriptive cross-sectional study was performed at KTH Peshawar from February to august 2018. It was designed to analyze C-reactive protein levels among acute appendicitis patients using positive and negative predictive values. Histopathologically confirmed appendicitis patients were included. Results: In the current study, 216 patients suffering from Acute appendicitis were studied observed. The symptoms duration was < 2days in 75% patients while >2 days symptoms were found in 25% population. Majority patients were poor (46%), followed by middle class (42%), and rich (12%). Obesity was only observed in 22% patients suffering from AA. Diabetes and hypertension was observed in 18% and 15% patients respectively. Diagnostic accuracy of acute appendicitis was also calculated between CRP and Histopathology findings based on age, diabetes mellitus, gender, hypertension, obesity, and period of symptoms. Conclusion: Our study concludes that the acute appendicitis symptoms appeared in less than two days. Acute appendicitis predominantly found in poor and middle class patients. Acute appendicitis should be diagnosed based mostly on its clinical symptoms. Despite the fact that CRP is a particularly helpful marker in the clinical diagnosis of acute appendicitis, general surgeons must apply their clinical judgement. The function of CRP in acute appendicitis should be examined in future research with a bigger sample size. Keywords: C-reactive protein level, Socioeconomical factors, Acute Appendicitis, Diagnostic accuracy, Histopathological.

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Diagnostic accuracy of laboratory markers for diagnosis of acute appendicitis in children

Cited by 8 publications

References 18 publications

Mean Platelet Volume in the Diagnosis of Acute Appendicitis in the Pediatric Population: A Systematic Review and Meta-Analysis

Mean Platelet Volume in the Diagnosis of Acute Appendicitis in the Pediatric Population: A Systematic Review and Meta-Analysis

Mean Platelet Volume versus Alvarado Score as Predictor of Acute Appendicitis

Socioeconomic, Laboratory and Associated Factors in Patients Suffering From Acute Appendicitis

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