Diagnostic accuracy of icteric index to detect abnormal total bilirubin values

Salinas, María; López-Garrigós, Maite; Lugo, Javier; Gutiérrez, Mercedes; Flors, Lucía; Leiva‐Salinas, Carlos

doi:10.1136/jclinpath-2012-200811

Cited by 26 publications

(12 citation statements)

References 17 publications

(12 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, this would be at least partly responsible for differences in results. Salinas et al did not clearly discriminate between results on serum samples and plasma samples; they described, however, a small stat subpopulation showing similar characteristics to those of our plasma samples, with a substantial worse sensitivity (77.4%) than in other examined populations 1. This group of samples was measured on a different platform (Dimension RxL Max, Siemens Healthcare Diagnostics), and we may suppose that, being stat samples, plasma was used.…”

mentioning

confidence: 49%

See 1 more Smart Citation

Measurement of icteric index as approach to detect abnormal total bilirubin values

et al. 2013

View full text Add to dashboard Cite

We read with great interest the article by Salinas et al 1 suggesting the use of the icteric index (II) as a front-line test for the preliminary identification of blood samples with abnormal total bilirubin (TB) concentrations. Following the authors' suggestion, we were encouraged to experimentally confirm their findings in our own hospital setting. Particularly, in our laboratory we use platforms (Cobas c 501 and Integra 800) and reagents of the same vendor (Roche Diagnostics) used by Salinas et al, and we think that our findings could contribute further evidence to their results, even if obtained with instruments of different series.We evaluated all the measurements of TB requested to our laboratory between January and December 2011 and their corresponding II values. TB concentrations and II were measured on Cobas c 501 using serum samples (routine) and on Integra 800 using lithium-heparin plasma samples (stat). Both systems use for TB the same diazo-based colorimetric assay, and for the II determination, an assay based on calculations of absorbance measurements of diluted samples. Statistical evaluation, including linear regression analysis, calculations of sensitivity, specificity, positive (LR+) and (LR−) negative likelihood ratios, positive predictive value (PPV) and negative predictive value (NPV) was performed for both serum and plasma samples, separately, by applying the same cut-off values used by Salinas et al, that is, 1.2 mg/dl (20.5 μmol/l) for TB concentrations and 2 for II. The analysis was Downloaded from *TB >1.2 mg/dl and icteric index <2. †TB ≤1.2 mg/dl and icteric index ≥2. LR+, positive likelihood ratio; LR−, negative likelihood ratio; NPV, negative predictive value; PPV, positive predictive value.

show abstract

mentioning

confidence: 49%

“…We read with great interest the article by Salinas et al 1 suggesting the use of the icteric index (II) as a front-line test for the preliminary identification of blood samples with abnormal total bilirubin (TB) concentrations. Following the authors’ suggestion, we were encouraged to experimentally confirm their findings in our own hospital setting.…”

mentioning

confidence: 99%

Measurement of icteric index as approach to detect abnormal total bilirubin values

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Time of exerting effects: The time of icteric index that was measured with a transcutaneous jaundice meter (JM-103, Chengdu Beisida Instruments Co., Ltd.) decreased. 5 Clinical outcomes: Markedly effective: Fading of yellowish pigmentation and obvious decrease in serum bilirubin level. Effective: Basic fading of yellowish pigmentation and moderate decrease in serum bilirubin level.…”

Section: Methodsmentioning

confidence: 99%

Therapeutic effects of probiotics on neonatal jaundice

Liu¹,

Liu²,

Wang³

et al. 2015

Pak J Med Sci

View full text Add to dashboard Cite

Objective:To evaluate the therapeutic effects of probiotics on neonatal jaundice and the safety.Methods:Sixty-eight neonates with jaundice were divided into a control group and a treatment group (n=34) randomly, and treated by blue light phototherapy and that in combination with probiotics. The serum bilirubin levels were detected before and 1, 4, 7 days after treatment. The time when therapy showed effects and jaundice faded, clinical outcomes as well as adverse reactions were recorded. The categorical data were expressed as (±s) and compared by t test. The numerical data were expressed as (case, %) and compared by χ² test. P<0.05 was considered statistically significant.Results:Serum bilirubin levels of the two groups were similar before treatment (P>0.05). The levels significantly decreased 1, 4 and 7 days after treatment (P<0.05), but there was no significant inter-group difference on the post-treatment 1st day (P>0.05). The treatment group underwent more significant decreases on the 4th and 7th days than the control group did (P=0.002, 0.001). In the treatment group, the therapy exerted effects on (1.0±0.5) d and jaundice faded on (3.8±1.7) d, which were (2.6±0.6) d and (5.3±2.1) d respectively in the control group (P=0.001, 0.002). The effective rate of the treatment group significantly exceeded that of the control group (P=0.002). There were no obvious adverse reactions in either group.Conclusions:Probiotics lowered the serum bilirubin levels of neonates with jaundice rapidly, safely and significantly, and accelerated jaundice fading as well. This method is worthy of application in clinical practice.

show abstract

“…There was, however, a great variability between areas. Serum ALT is the recommended screening test for liver disease, ALP is the second choice and bilirubin should be requested only when icterus is suspected [18]. Such an approach would reduce aspartate transaminase (AST)/ALT, tBIL/ALP, LDH/ALT and gamma-glutamyl transferase (GGT)/ALT ratios.…”

Section: Discussionmentioning

confidence: 99%